Hypoxia-Induced Arterial Endothelin Does Not Influence Peripheral Vascular Tone

1995 ◽  
Vol 26 ◽  
pp. S242-243 ◽  
Author(s):  
Gerard J. Blauw ◽  
Rudi G. J. Westendorp ◽  
Nidhi Srivastava ◽  
Koos Burggraaf ◽  
Marijke Frölich ◽  
...  
Keyword(s):  
Vascular Tone ◽  
Peripheral Vascular ◽  
Peripheral Vascular Tone

Neuronal histamine release elicited by hyperthermia mediates tracheal dilation and pressor response

2001 ◽  
Vol 280 (6) ◽  
pp. R1748-R1754 ◽  
Author(s):  
Mitsuko Kanamaru ◽  
Michiko Iwase ◽  
Ikuo Homma
Keyword(s):  
Histamine Release ◽  
Medulla Oblongata ◽  
Vascular Tone ◽  
Pressor Response ◽  
Ventrolateral Medulla ◽  
Peripheral Vascular ◽  
Histaminergic Neurons ◽  
Tracheal Pressure ◽  
Neuronal Histamine ◽  
Peripheral Vascular Tone

Whether brain histaminergic neurons contribute to the regulation of tracheal tone and peripheral vascular tone under hyperthermia was investigated in anesthetized rabbits. Histamine release from the rostral ventrolateral medulla (RVLM), the raphe nuclei, and the solitary nucleus of the medulla oblongata was significantly increased by hyperthermia. The increased histamine was significantly suppressed by 10−6 M tetrodotoxin microdialyzed in each area. Tracheal pressure and mean arterial pressure were significantly decreased and increased by hyperthermia, respectively. An H1-receptor antagonist, 5 × 10−6 M (+)-chlorpheniramine, bilaterally microdialyzed in the RVLM significantly enhanced histamine release in the RVLM as well as significantly suppressed tracheal dilation and pressor response caused by hyperthermia. These data indicate that histamine release in the medulla oblongata is enhanced by hyperthermia. The enhanced histamine is the neuronal origin and the cause of tracheal dilation and pressor response at least via H1 receptors in the RVLM. Brain histaminergic neurons play important roles in tracheal tone and peripheral vascular tone via H1 receptors in the RVLM and homeostasis on body temperature.

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