Influence of Chemotherapy for Gestational Trophoblastic Disease on Subsequent Pregnancy Outcome

1999 ◽  
Vol 54 (2) ◽  
pp. 108-109
Author(s):  
Robert P. Woolas ◽  
Mark Bower ◽  
Edward S. Newlands ◽  
Michael Seckl ◽  
Dee Short ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Gestational Trophoblastic Disease ◽  
Subsequent Pregnancy ◽  
Trophoblastic Disease

Influence of chemotherapy for gestational trophoblastic disease on subsequent pregnancy outcome

1998 ◽  
Vol 105 (9) ◽  
pp. 1032-1035 ◽  
Author(s):  
Robert P. Woolas ◽  
Mark Bower ◽  
Edward S. Newlands ◽  
Michael Seckl ◽  
Dee Short ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Gestational Trophoblastic Disease ◽  
Subsequent Pregnancy ◽  
Trophoblastic Disease

scholarly journals Pregnancy outcomes after chemotherapy for trophoblastic neoplasia

2016 ◽  
Vol 62 (9) ◽  
pp. 837-842
Author(s):  
MILA TREMENTOSA GARCIA ◽  
LAWRENCE HSU LIN ◽  
KOJI FUSHIDA ◽  
ROSSANA PULCINELI VIEIRA FRANCISCO ◽  
MARCELO ZUGAIB
Keyword(s):  
Congenital Abnormalities ◽  
Gestational Trophoblastic Disease ◽  
Subsequent Pregnancy ◽  
Cochrane Library ◽  
Reproductive Outcomes ◽  
Successful Development ◽  
Disease Remission ◽  
Trophoblastic Disease ◽  
Clinical Surveillance ◽  
Hydatidiform Moles

SUMMARY Introduction The successful development of chemotherapy enabled a fertilitysparing treatment for patients with trophoblastic neoplasia. After disease remission, the outcome of a subsequent pregnancy becomes a great concern for these women. Objective To analyze existing studies in the literature that describe the reproductive outcomes of patients with trophoblastic neoplasia treated with chemotherapy. Method Systematic review was performed searching for articles on Medline/ Pubmed, Lilacs and Cochrane Library databases, using the terms “gestational trophoblastic disease” and “pregnancy outcome”. Results A total of 18 articles were included. No evidence of decreased fertility after chemotherapy for trophoblastic neoplasia was observed. The abortion rates in patients who conceived within 6 months after chemotherapy was higher compared to those who waited longer. Some studies showed increased rates of stillbirth and repeat hydatidiform moles. Only one work showed increased congenital abnormalities. Conclusion The pregnancies conceived after chemotherapy for trophoblastic neoplasia should be followed with clinical surveillance due to higher rates of some pregnancy complications. However, studies in the literature provide reassuring data about reproductive outcomes of these patients.

scholarly journals A prospective study of gestational trophoblastic disease profile with special reference to mortality and pregnancy outcome after successful management of the same

2019 ◽  
Vol 6 (10) ◽  
pp. 4363
Author(s):  
Abantika Bhattacharya ◽  
Tanmay Kanti Panja ◽  
Amiya Bhattacharya ◽  
Baijayanti Baur ◽  
Kishore P. Madhwani
Keyword(s):  
Pregnancy Outcome ◽  
Fetal Tissue ◽  
Gestational Trophoblastic Disease ◽  
Reproductive Age ◽  
Molar Pregnancy ◽  
Successful Management ◽  
Abnormal Growth ◽  
Trophoblastic Disease ◽  
A Prospective Study ◽  
Reproductive Age Group

Background: Gestational trophoblastic disease (GTD) is a group of rare tumors that involve abnormal growth of cells inside a woman's uterus. GTD does not develop from cells of the uterus like cervical cancer or endometrial (uterine lining) cancer do. Instead, these tumors start in the cells that would normally develop into the placenta during pregnancy. GTD is unique because the maternal lesions arise from the fetal tissue as a molar pregnancy. All forms of GTD can be treated. In most cases the treatment produces a complete cure. The study was conducted to assess the various presenting features of GTD and factors associated with it.Methods: It was an observational hospital based prospective epidemiological study. Complete enumeration technique was followed and a total of 305 female patients were included in the sample. A pre-designed and pre-tested interview schedule was used to record different information and detailed history.Results: Of the 305 patients studied, 67.2% were diagnosed with H. mole, 23% patients were diagnosed with gestational trophoblastic tumor, among them 4.9% had choriocarcinoma. Majority were primigravida and of blood group O type. Pregnancy outcome after successful management of GTD were 63.3% had full term pregnancy, 20% cases had repeat molar pregnancy, 10% had spontaneous abortion while 6.7% (2/30) had pre term delivery.Conclusions: Gestational trophoblastic disease is seen most commonly in reproductive age group. If it is not diagnosed on time it can be fatal. This is a highly curable tumor even in the presence of distant metastasis.

Subsequent Pregnancy Experience in Patients With Gestational Trophoblastic Disease

1994 ◽  
Vol 49 (8) ◽  
pp. 544-545 ◽  
Author(s):  
Ross S. Berkowitz ◽  
Marilyn R. Bernstein ◽  
Olivier Laborde ◽  
Donald P. Goldstein
Keyword(s):  
Gestational Trophoblastic Disease ◽  
Subsequent Pregnancy ◽  
Trophoblastic Disease

Spectrum of Pathological Lesions in Uterine Specimens with Focus on Gestational Trophoblastic Disease in Karachi

2020 ◽  
Keyword(s):  
Hydatidiform Mole ◽  
Endometrial Stromal Sarcoma ◽  
Gestational Trophoblastic Disease ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
P Value ◽  
Cross Sectional ◽  
Endometrial Polyps ◽  
Trophoblastic Disease ◽  
Proliferative Endometrium

Background: The most common benign pathological lesion in women of reproductive age is uterine leiomyoma. Gestational trophoblastic disease includes tumors and tumor like lesions originating from trophoblastic tissue. The aim of this study was to find the spectrum of molar pregnancy and uterine pathologies focusing on gestational trophoblastic disease as no study has been done in the past few years. Methods: Endometrial and uterine specimens of patients (n=436) between the ages of 15-65 years were collected from a private hospital in Karachi from December 2018 to December 2019. This cross-sectional study was carried out by pathological diagnosis of patients’ samples under light microscopy using hematoxylin and eosin staining. Stratification was done about age and nature of specimen to control the effect modifiers. The post stratification Chi square test was applied and p value <0.05 was considered significant. Results: Mean age of the patients was 36.1 years ±7.8. Total 436 uterine biopsies included 260(59.6%) hysterectomies, 56(12.8%) endometrial curetting’s, 117(26.8%) evacuation specimens and 3(0.7%) polypectomies. Common pathologies included 124(28.4%) leiomyomas, 61(14%) proliferative endometrium, 52(11.9%) adenomyosis and 32(7.3%) endometrial polyps. Gestational trophoblastic disease was seen in 9(2.06%). Seven (87.5%) were partial hydatidiform moles, one (12.5%) exaggerated placental site reaction and one choriocarcinoma. Mole was common between 26-30 years with mean age of 27.2 years and prevalence was 6/100 abortions. Conclusion: Leiomyoma was the commonest (28.4%) uterine pathology followed by proliferative endometrium (14.5%). However, endometrial stromal sarcoma and endometriosis were found 0.2% each. High prevalence of mole was seen in this study. Partial mole was most common and choriocarcinoma was least common. Keywords: Hydatidiform Mole; Pathology; Prevalence.

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