Early Predictors of Adverse Outcome in Term Infants With Post-Asphyxial Hypoxic Ischemic Encephalopathy

2001 ◽  
Vol 56 (1) ◽  
pp. 15-16
Author(s):  
V. C. Toh
Keyword(s):  
Adverse Outcome ◽  
Hypoxic Ischemic Encephalopathy ◽  
Term Infants ◽  
Early Predictors ◽  
Ischemic Encephalopathy

scholarly journals Automated EEG background analysis to identify neonates with hypoxic-ischemic encephalopathy treated with hypothermia at risk for adverse outcome: A pilot study

2019 ◽  
Vol 60 (1) ◽  
pp. 50-58 ◽  
Author(s):  
Anneleen Dereymaeker ◽  
Vladimir Matic ◽  
Jan Vervisch ◽  
Perumpillichira J. Cherian ◽  
Amir H. Ansari ◽  
...  
Keyword(s):  
At Risk ◽  
Pilot Study ◽  
Adverse Outcome ◽  
Hypoxic Ischemic Encephalopathy ◽  
Ischemic Encephalopathy

Blood Carbon Dioxide Levels and Adverse Outcome in Neonatal Hypoxic-Ischemic Encephalopathy

2009 ◽  
Vol 27 (05) ◽  
pp. 361-365 ◽  
Author(s):  
Montasser Nadeem ◽  
Deirdre Murray ◽  
Geraldine Boylan ◽  
Eugene Dempsey ◽  
C. Anthony Ryan
Keyword(s):  
Carbon Dioxide ◽  
Adverse Outcome ◽  
Hypoxic Ischemic Encephalopathy ◽  
Carbon Dioxide Levels ◽  
Ischemic Encephalopathy

scholarly journals Association between Urinary Lactate to Creatinine Ratio and Neurodevelopmental Outcome in Term Infants with Hypoxic-Ischemic Encephalopathy

2008 ◽  
Vol 153 (3) ◽  
pp. 375-378.e2 ◽  
Author(s):  
William Oh ◽  
Rebecca Perritt ◽  
Seetha Shankaran ◽  
Matthew Merritts ◽  
Edward F. Donovan ◽  
...  
Keyword(s):  
Neurodevelopmental Outcome ◽  
Hypoxic Ischemic Encephalopathy ◽  
Creatinine Ratio ◽  
Term Infants ◽  
Ischemic Encephalopathy

scholarly journals Effect of Elevated Temperature on Immediate Neurodevelopmental Outcome in Term Neonates with Hypoxic-Ischemic Encephalopathy

2019 ◽  
Vol 9 (3) ◽  
pp. 160-165
Author(s):  
Bithi Debnath ◽  
Naila Zaman Khan ◽  
Dilara Begum ◽  
Asma Begum Shilpi ◽  
Shaheen Akter
Keyword(s):  
Elevated Temperature ◽  
Rectal Temperature ◽  
Neurodevelopmental Outcome ◽  
Hypoxic Ischemic Encephalopathy ◽  
Neurodevelopmental Outcomes ◽  
Term Infants ◽  
Term Neonates ◽  
Risk Of Death ◽  
The Mean ◽  
Ischemic Encephalopathy

Background: Among term infants, hypoxic-ischemic encephalopathy due to acute perinatal asphyxia remains an important cause of neurodevelopmental deficits in childhood. Treatment is currently limited to supportive intensive care, without any specific brain-oriented therapy. Objective: To determine whether the risk of death or moderate/severe neurodevelopmental impairment in term infants with hypoxic-ischemic encephalopathy increases with relatively high skin or rectal temperature between 12 and 72 hours of birth. Materials and Methods: This was a prospective observational study. Asphyxiated newborns who came within 12 hours of birth were enrolled in this study. Both axillary and rectal temperature were recorded 6 hourly for 72 hours and each infant`s temperature for each site were rank ordered. Then mean of all axillary and rectal temperatures of each neonate was calculated. Outcomes were related to temperatures in logistic regression analyses for the elevated/relatively high temperatures and normal/low temperatures group, with adjustment of the level of encephalopathy and gender. Results: The mean axillary temperature was 36.07 ± 6.10C and in 25.71%, 11.92% and 6.32% cases axillary temperatures were >370C, >37.50C and >380C respectively. The mean rectal temperature was 36.8 ± 60C, and in 43.53%, 30.02% and 19.97% cases rectal temperatures were >370C, >37.50C and >380C respectively. Mean ambient temperature was 26.170C. There was significant correlation between axillary and rectal temperatures (r=0.889). For elevated temperature, the odds of death or moderate to severe impairment increased 8.9-fold (CI 0.906–88.18) and the odds of death alone increased 4.6-fold (CI 0.373–56.83). The odds of impairment increased 1.84-fold (CI 0.45– 7.50). Conclusion: Relatively high temperature during usual care after hypoxic-ischemia in term neonates was associated with adverse neurodevelopmental outcomes. J Enam Med Col 2019; 9(3): 160-165

Prognostic Markers in Term Infants with Hypoxic–Ischemic Encephalopathy: Comparative Analysis of MRI, EEG, and Apgar Scores

2017 ◽  
Vol 16 (01) ◽  
pp. 008-014 ◽  
Author(s):  
Elissa Yozawitz ◽  
Ajay Goenka
Keyword(s):  
Hypoxic Ischemic Encephalopathy ◽  
Neurological Deficits ◽  
Term Infants ◽  
Term Outcome ◽  
Apgar Scores ◽  
Long Term Outcome ◽  
Perinatally Acquired ◽  
Magnetic Resonance Imaging Mri ◽  
Poor Outcomes ◽  
Ischemic Encephalopathy

AbstractHypoxic–ischemic encephalopathy (HIE) is a frequent cause of perinatally acquired brain injury resulting in abnormal neurological consequences. In this retrospective study, we evaluated 68 neonates with clinical evidence of HIE to investigate the utility of magnetic resonance imaging (MRI), electroencephalography (EEG), and Apgar scores, individually and in combination, as predictors of long-term outcome. Six infants died during treatment, and 46 of the remaining 62 infants (74%) received follow-up neurological assessments at ages 6 to 24 months. The outcome was dichotomously classified as good (reflecting “normal development”) or as poor (reflecting “neurological deficits” based upon attainment of developmental milestones or death). Abnormal Apgar scores, MRIs, and EEGs had sensitivities of 50, 84, and 95% for predicting “neurological deficit.” Corresponding specificities were 85, 66, and 18%. However, the combination of abnormal Apgar scores, MRIs, and EEGs in predicting poor outcomes (i.e., “neurological deficits” or death) had sensitivity and specificity of 100%. In addition, the combination of abnormal Apgar scores, MRIs, and EEGs provided a positive predictive value of 100% in assessing poor outcome as compared with 73% (p = 0.2) for Apgar scores, 71% (p = 0.01) for MRIs, and 56% (p = 0.001) for EEGs.

Sign in / Sign up

Export Citation Format

Share Document