Postmortem Autolysis in the Pancreas

Pancreas ◽  
1990 ◽  
Vol 5 (1) ◽  
pp. 91-94 ◽  
Author(s):  
Michio Shimizu ◽  
Takuji Hayashi ◽  
Yoichi Saitoh ◽  
Kyosuke Ohta ◽  
Hiroshi Itoh
Keyword(s):  
Postmortem Autolysis

Renal Papillary Rarefaction: An Artifact Mimicking Papillary Necrosis

2019 ◽  
Vol 47 (5) ◽  
pp. 645-648
Author(s):  
John Curtis Seely ◽  
Sabine Francke ◽  
Steven R. Mog ◽  
Kendall S. Frazier ◽  
Gordon C. Hard
Keyword(s):  
Rat Kidney ◽  
Renal Papilla ◽  
Papillary Necrosis ◽  
Normal Appearance ◽  
Fixed Tissue ◽  
Careful Observation ◽  
Slide Preparation ◽  
Tissue Handling ◽  
Incorrect Diagnosis ◽  
Postmortem Autolysis

In histopathology, the presence of a tissue change that does not represent the tissue’s normal appearance can often lead to an incorrect diagnosis and interpretation. These changes are collectively known as “artifacts” resulting from postmortem autolysis, improper fixation, problems with tissue handling or slide preparation procedures. Most tissue artifacts are obvious, yet some artifacts may be subtle, occur in relatively well-fixed tissue, and demand careful observation to avoid confusion with real biological lesions. The kidney often contains artifacts that may be observed throughout all regions of the renal parenchyma. Cortical tubule artifacts present the greatest challenge when discerning an artifact versus an induced lesion following exposure to a xenobiotic. However, confounding artifacts observed at the tip of the renal papilla may also be problematic for the pathologist. An uncommon artifact involving tinctorial alteration and rarefaction affecting the papillary tip of the rat kidney is described here and differentiated from treatment induced lesions of renal papillary necrosis.

Creatine kinase isoenzyme patterns in human tissue obtained at surgery.

1976 ◽  
Vol 22 (2) ◽  
pp. 173-175 ◽  
Author(s):  
S H Tsung
Keyword(s):  
Creatine Kinase ◽  
Human Tissue ◽  
Creatine Kinase Isoenzyme ◽  
Quantitative Distribution ◽  
Immunological Method ◽  
Creatine Kinase Isoenzymes ◽  
Isoenzyme Patterns ◽  
Postmortem Autolysis

Abstract Chromatography on DEAE-Sephadex A-50 was applied to study the quantitative distribution of creatine kinase isoenzymes in extracts of human tissue obtained during surgery. The results are compared with those determined by an immunological method [Clin. Chim. Acta 58, 223 (1975)]. Conflicting results for some organs as reported by the two methods are probably attributable to postmortem autolysis.

A study of postmortem autolysis in the human organ of corti

1985 ◽  
Vol 237 (3) ◽  
pp. 333-342 ◽  
Author(s):  
Joseph B. Nadol ◽  
Barbara Burgess
Keyword(s):  
Organ Of Corti ◽  
Human Organ ◽  
Postmortem Autolysis

scholarly journals Kidney injury molecule-1 identifies antemortem injury in postmortem adult and fetal kidney

2018 ◽  
Vol 315 (6) ◽  
pp. F1637-F1643 ◽  
Author(s):  
Wenqing Yin ◽  
Ping L. Zhang ◽  
Jacqueline K. Macknis ◽  
Fan Lin ◽  
Joseph V. Bonventre
Keyword(s):  
Serum Creatinine ◽  
Tissue Damage ◽  
Kidney Injury ◽  
Postmortem Examination ◽  
Tubular Injury ◽  
Fetal Kidney ◽  
Pulmonary Alveoli ◽  
Kidney Injury Molecule 1 ◽  
Postmortem Autolysis

There is currently no technique to unambiguously diagnose antemortem kidney injury on postmortem examination since postmortem tissue damage and autolysis are common. We assessed the ability to detect kidney injury molecule-1 (KIM-1) expression in adult and fetal kidneys examined at autopsy. In adult kidneys ( n = 52 subjects), we found that the intensity of KIM-1 staining significantly correlated with the antemortem level of serum creatinine, and this was independent of the extent of tissue autolysis. In addition, kidneys from a total of 52 fetal/neonatal subjects, 30 stillborns and 22 liveborns, were assessed for KIM-1 staining. Given that serum creatinine is unreliable and often unavailable in fetuses and newborns, we assessed preterminal hypoxia in fetuses by the presence of squames in pulmonary alveoli and by required intubation. KIM-1 expression correlated with these clinical indexes of hypoxia. The expression of KIM-1 was seen in a majority of the fetal and neonatal autopsy kidneys (77%, 40/52) as early as 16 wk of gestation, even in the presence of autolysis. Thus KIM-1 is a specific and stable marker of antemortem tubular injury in kidneys of adults and fetuses despite postmortem autolysis.

Effects of postmortem autolysis on the lipids of rat spinal cord

1981 ◽  
Vol 38 (1) ◽  
pp. 219-228 ◽  
Author(s):  
Lynne A. Torello ◽  
Allan J. Yates ◽  
Lloyd A. Horrocks
Keyword(s):  
Spinal Cord ◽  
Rat Spinal Cord ◽  
Postmortem Autolysis

Effect of postmortem autolysis on Na,K-ATPase activity and antigenicity in the gerbil cochlea

1995 ◽  
Vol 89 (1-2) ◽  
pp. 14-20 ◽  
Author(s):  
Daniel A. Vincent ◽  
Michael Anne Gratton ◽  
Brendan J. Smyth ◽  
Bradley A. Schulte
Keyword(s):  
Atpase Activity ◽  
Postmortem Autolysis
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