A NOVEL ROLE FOR THE INDUCIBLE ISOFORM OF NITRIC OXIDE SYNTHASE (iNOS) ON THE ANTI-INFLAMMATORY EFFECT OF STATINS.

Shock ◽  
2001 ◽  
Vol 15 (Supplement) ◽  
pp. 94-95
Author(s):  
Rosario Scalia ◽  
Timothy J. Stalker ◽  
Allan M. Lefer
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Anti Inflammatory ◽  
Oxide Synthase ◽  
Inflammatory Effect

scholarly journals Anti-Inflammatory Effect of Phytoncide in an Animal Model of Gastrointestinal Inflammation

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1895
Author(s):  
Azra Memon ◽  
Bae Yong Kim ◽  
Se-eun Kim ◽  
Yuliya Pyao ◽  
Yeong-Geun Lee ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Animal Model ◽  
Gastric Ulcer ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Inos Expression ◽  
Gastrointestinal Inflammation ◽  
Anti Inflammatory ◽  
Oxide Synthase ◽  
Inflammatory Effect

Background: Phytoncide is known to have antimicrobial and anti-inflammatory properties. Purpose: This study was carried out to confirm the anti-inflammatory activity of two types of phytoncide extracts from pinecone waste. Methods: We made two types of animal models to evaluate the efficacy, an indomethacin-induced gastroenteritis rat model and a dextran sulfate sodium-induced colitis mouse model. Result: In the gastroenteritis experiment, the expression of induced-nitric oxide synthase (iNOS), a marker for inflammation, decreased in the phytoncide-supplemented groups, and gastric ulcer development was significantly inhibited (p < 0.05). In the colitis experiment, the shortening of the colon length and the iNOS expression were significantly suppressed in the phytoncide-supplemented group (p < 0.05). Conclusions: Through this study, we confirmed that phytoncide can directly inhibit inflammation in digestive organs. Although further research is needed, we conclude that phytoncide has potential anti-inflammatory properties in the digestive tract and can be developed as a functional agent.

scholarly journals The nitric oxide synthase 2 pathway is targeted by both pro- and anti-inflammatory treatments in the immature human intestine

Nitric Oxide ◽  
2017 ◽  
Vol 66 ◽  
pp. 53-61 ◽  
Author(s):  
Emanuela Ferretti ◽  
Eric Tremblay ◽  
Marie-Pier Thibault ◽  
David Grynspan ◽  
Karolina M. Burghardt ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Human Intestine ◽  
Anti Inflammatory ◽  
Nitric Oxide Synthase 2 ◽  
Oxide Synthase
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