CORRELATION OF QUALITY OF LIFE WITH CLINICAL SIGNS AND SYMPTOMS AT THE TIME OF GLAUCOMA DIAGNOSIS

1999 ◽  
Vol 8 (Supplement 1) ◽  
pp. S9
Author(s):  
R. Mills
Keyword(s):  
Quality Of Life ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Glaucoma Diagnosis ◽  
Clinical Signs And Symptoms

Pain and fatigue

2013 ◽  
pp. 93-99
Author(s):  
Candy McCabe ◽  
Richard Haigh ◽  
Helen Cohen ◽  
Sarah Hewlett
Keyword(s):  
Quality Of Life ◽  
Management Strategies ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Self Management ◽  
Management Support ◽  
Charitable Organizations ◽  
Assessment And Treatment ◽  
Clinical Signs And Symptoms

Pain and fatigue are the prominent problems for those with a rheumatic disease, and are often underestimated by clinicians. Symptoms may fluctuate in quality and intensity over time and commonly will vary over the course of a day. For pain, clinical signs and symptoms will be dependent on the source of the pain and whether causative underlying pathology is identifiable or not. Fatigue may range from mild effects to total exhaustion and may include cognitive and emotional elements, with a complex, probably multicausal, pathway. Theoretical knowledge of potential mechanistic pathways for pain and fatigue should be used to inform assessment and treatment approaches. Best practice recommends a multidisciplinary and holistic treatment approach with the patient an active participant in the planning of their care, and self-management. Many patients with chronic musculoskeletal conditions will not achieve a pain-free or fatigue-free status. Medication use must therefore balance potential benefit against short- and long-term side effects. Rheumatology centres should offer specific fatigue and pain self-management support as part of routine care. Emphasis should be given to facilitating self-management strategies for both pain and fatigue to help the patient optimize their quality of life over years or a lifetime of symptoms. Interventions should include behaviour change and cognitive restructuring of pain/fatigue beliefs, as well as access to relevant self-help groups and charitable organizations. Referral for specialist advice from regional or national clinics on pain relief and management should be considered if pain interferes significantly with function or quality of life despite local interventions.

Local Management of Malignant and Unresectable Fungating Wounds: PEBO Assessment

2021 ◽  
pp. 153473462110534
Author(s):  
Agata Janowska ◽  
Giulia Davini ◽  
Valentina Dini ◽  
Michela Iannone ◽  
Riccardo Morganti ◽  
...  
Keyword(s):  
Public Health ◽  
Quality Of Life ◽  
Clinical Signs ◽  
Case Series ◽  
Signs And Symptoms ◽  
Local Management ◽  
Occlusive Dressings ◽  
Clinical Signs And Symptoms ◽  
Clinical Conditions

Malignant fungating wounds (MFWs) represent a major problem for public health. The most common symptoms associated with MFWs are pain, exudate, bleeding and odor. The aim of the study was to optimize the local management and dressing of MFWs. We developed a standardized 4- step approach to MFWs based on Pain, Exudate, Bleeding and Odor management in a case series of 24 patients: we call this the PEBO approach. We analyzed etiologies, localization, Quality of Life (QoL), pain and clinical signs and symptoms. We assessed the ulcers at baseline, after two weeks and after one month. In our study, most patients showed an improvement in the QoL using PEBO approach, although some experienced a deterioration in their general clinical conditions. Non-cytolesive cleansing, atraumatic dressings were applied to allow pain relief. Non-adherent dressings were combined with a secondary dressing in the case of exudate. Achieving hemostasis with dressing or medication is a priority in MFW management. Antibacterial dressings and odor absorbent dressings were used for odor absorption. Surgical debridement, adherent dressing and occlusive dressings were avoided. Dressing changes were programmed twice a week for four weeks. PEBO simplified the complex aspects of this type of ulcer, and could help physicians, nurses, and also the rest of the team, including the patients themselves and their family, in the multidisciplinary palliative care of MFWs.

scholarly journals Treatment effectiveness of pasireotide on health-related quality of life in patients with Cushing's disease

2014 ◽  
Vol 171 (1) ◽  
pp. 89-98 ◽  
Author(s):  
Susan M Webb ◽  
John E Ware ◽  
Anna Forsythe ◽  
Min Yang ◽  
Xavier Badia ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cushing’S Disease ◽  
Treatment Effectiveness ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Cushing's Disease ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

ObjectiveCushing's disease (CD) can significantly impair patients' health-related quality of life (HRQOL). This study investigated the treatment effectiveness of pasireotide on HRQOL of CD patients, and assessed the relationships between HRQOL and urinary free cortisol (UFC) and CD-related signs and symptoms.DesignIn this phase III, randomized, double-blind study, patients with UFC ≥1.5×upper limit of normal (ULN) received s.c. pasireotide 600 or 900 μg twice daily. The trial primary endpoint was UFC at or below ULN at month 6 without dose titration. Open-label treatment continued through month 12. HRQOL was measured using the Cushing's Quality of Life Questionnaire (CushingQoL) instrument at baseline and follow-up visits until month 12 during which clinical signs and features of CD, and the Beck Depression Inventory II (BDI-II), were also collected.MethodsPearson's/Spearman's correlations between changes in CushingQoL and changes in clinical signs and symptoms were assessed. Changes in CushingQoL and the proportion of patients achieving a clinically meaningful improvement in CushingQoL were also compared among patients stratified by mean UFC (mUFC) control status (controlled, partially controlled, and uncontrolled) at month 6. Analyses were also conducted at month 12, with multivariable adjustment for baseline characteristics and CushingQoL.ResultsChange in CushingQoL was significantly correlated with changes in mUFC (r=−0.40), BMI (r=−0.39), weight (r=−0.41), and BDI-II (r=−0.54) at month 12 but not at month 6. The percentage of CushingQoL responders at month 12 based on month 6 mUFC control status were as follows: 63, 58.8, and 37.9% in the controlled, partially controlled, and uncontrolled groups respectively. Adjusted CushingQoL scores at month 12 were 58.3 for controlled patients (Δ=11.5 vs uncontrolled,P=0.012) and 54.5 for partially controlled patients (Δ=7.7 vs uncontrolled,P=0.170).ConclusionsPasireotide treatment can result in a meaningful HRQOL improvement among those who complete a 12-month treatment period, most often among patients achieving biochemical control.

scholarly journals Endodontic retreatment due to secondary periapical injury: case report

2020 ◽  
Vol 9 (6) ◽  
pp. 503-506
Author(s):  
Monica Soares de Albuquerque ◽  
Armiliana Soares Nascimento ◽  
Cácio Lopes Mendes ◽  
Leonardo José Rodrigues de Oliveira ◽  
Marília de Lima Soares ◽  
...  
Keyword(s):  
Root Canal ◽  
Clinical Signs ◽  
In Vitro Study ◽  
Signs And Symptoms ◽  
Endodontic Treatment ◽  
Endodontically Treated Teeth ◽  
Clinical Signs And Symptoms ◽  
Endodontic Retreatment

Pulp diseases commonly happens because of the actions of bacteriological factors and show their characteristic signs and symptoms over the time. With pulp necrosis, a degenerative process starts and when there is no early treatment, it is possible to occur periapical lesions as a result of aggression to the pulp. In cases of periapical secondary lesions, clinical signs and symptoms persist and are related to secondary infection due to persistent bacterial contamination, also to operative factors, inadequate obturation or poor coronary restoration. This study aimed to report a case of endodontic retreatment and clinical and radiographic follow-up for 8 years, of chronic periapical abscess case, in which after retreatment, clinical signs and symptoms are no longer observed and bone neoformation is noticed. Descriptors: Periapical Diseases; Endodontics; Periapical Abscess. Referências Alani AH. Endodontic treatment of bilaterally occurring four-rooted maxillary second molars: case report. J Can Dent Assoc. 2003;69(11):733–35. Slowey RR. Radiographic aids in the detection of extra root canals. Oral Surg Oral Med Oral Pathol 1974;37(5):762-72 Bergenholtz G, Malmcrona E, Milthon R. Endodontic treatment and periapical status I. Radiographic evaluation of the frequency of endodontically treated teeth. Tandl€akartidningen. 1973; 65:64–73 (In Swedish, English summary). Buckley M, Spangberg LS. The prevalence and technical quality of endodontic treatment in an American subpopulation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;79(1):92–100. Saunders WP, Saunders EM, Sadiq J, Cruickshank E. Technical standard of root canal treatment in an adult Scottish sub-population. Br Dent J. 1997;182(10):382-86. Segura-Egea JJ, Jimenez-Pinzon A, Poyato-Ferrera M, Velasco-Ortega E, Rios-Santos JV. Periapical status and quality of root fillings and coronal restorations in an adult Spanish population. Int Endod J. 2004;37(8):525-30. Kabak Y, Abbott PV. Prevalence of apical  periodontitis and the quality of endodontic treatment in an adult Belarusian population. Int Endod J. 2005;38(4):238-45. Glickman GN. AAE consensus conference on diagnostic terminology: background and perspectives. J Endod. 2009;35:1619. Gutmann JL, Harrison JW. Surgical endodontics: an online study guide. Blackwell Scientific Publications; 1991. Molven O, Halse A, Grung B. Incomplete healing (scar tissue) after periapical surgery - radiographic findings 8 to 12 years after treatment. J Endod. 1996;22(5):264-68. Macedo, IL Retratamento endodôntico: opção terapêutica do insucesso endodôntico. BJHR. 2018;1(2):421-31. Souza VC et al. Tratamento do insucesso endodôntico. Rev Odontol Bras Central. 2018; 27:44-48. Bender IB, Seltzer S, Soltanoff W. Endodontic success – a reappraisal of criteria. Oral Surg Oral Med Oral Pathol. 1966; 22(6):790–802. Rubinstein R A, Kim S. Long-term follow-up of cases considered healed one year after apical microsurgery. J Endod. 2002; 28(5):378-83. Estrela C et al. Characterization of successful root canal treatment. Braz Dent J. 2014; 25(1):3-11 http://dx.doi.org/10.1590/0103-6440201302356 Kaled GH et al. Retratamento endodôntico: análise comparativa da efetividade da remoção da obturação dos canais radiculares realizada por três métodos. RGO, Rev. gaúch. odontol. (Online). 2011;59(1):103-8. Rossi-Fedele G, Ahmed HMA. Assessment of rootcanal filling removal effectiveness using micro–computedtomography: a systematic review. J Endod. 2017;43(4):520-26 Barbosa SV, Burkhard DH, Spanberg LSV. Cytotoxic effects of gutta-percha solvents. J Endod. 1994; 20(1):6-8. Zakariasen KL, Brayton SM, Collinson DM. Efficient and effective root canal retreatment without chloroform. J Canad Dent Assoc. 1990; 56(6):509-12. Pecora JD, Spano JC, Barbin EL. In vitro study on the softening of gutta-percha cones in endodontic retreatment. Brazilian. Braz Dent Journal. 1993; 4(1): 43-7. Scelza MF et al. Comparative SEM evaluation of three solvents used in endodontic retreatment: an ex vivo study. Journal of Applied Oral Science. 2008; 16(1):24-9. Marques da Silva B et al. Effectiveness of ProTaper, D-RaCe, and Mtwo retreatment files with and without supplementary instruments in the removal of root canal filling material. Int Endod J. 2012; 45(10):927-32 Song M1 et al. Analysis of the cause of failure in nonsurgical endodontic treatment by microscopic inspection during endodontic microsurgery. J Endod. 2011;37(11):1516-9. Albuquerque MS et al. Sealing Capacity of Bulk-fill Resin in Endodontically Treated Teeth. The Journal of Contemporary Dental Practice. 2019; 20(3): 311-17 Zancan RF, Vivan RR, Lopes MRM et al. Antimicrobial activity and physicochemical properties of calcium hydroxide pastes used as intracanal medication. J Endod. 2016. 42(12):1822-28. Buttler TK, Crawford JJ. The detoxifying effect of varying concentrations of sodium hypochlorite on endotoxins. J Endod. 1982; 8(2):59-66. Foley DB, Weine FS, Hagen JC, deObarrio JJ. Effectiveness of selected irrigants in the elimination of bacteroides meloninogenicus from the root canal system: an in vitro study. J Endod. 1983; 9(6):236-41. Abou-Ran M, Oglesby SW. The effects of temperature, concentration and tissue type on the solvent ability of sodium hypochlorite. J Endod. 1981; 7(8):376-7. Lee JK et al. Physicochemical Properties of Epoxy Resin-Based and Bioceramic-Based Root Canal Sealers. Bioinorg Chem Appl. 2017; 1-8.  Kandemir DG, Caliskan MK. A prospective Ramdomized  Comparative Study of Cold Lateral Condensation Versus Core/Guta Percha in Teeth with Periapical Lesions. J Endod. 2016; 42(2):206-10 Karaman E, Keskin B, Inan U. Three-year clinical evaluation of class II posterior composite restorations placed with different techniques and flowable composite linings in endodontically treated teeth. Clin Oral Investig. 2017; 21(2):709-16.

Pain and fatigue

2015 ◽  
Author(s):  
Candy McCabe ◽  
Richard Haigh ◽  
Helen Cohen ◽  
Sarah Hewlett
Keyword(s):  
Quality Of Life ◽  
Best Practice ◽  
Management Strategies ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Routine Care ◽  
Self Management ◽  
Management Support ◽  
Holistic Treatment

Pain and fatigue are the prominent problems for those with a rheumatic disease, and are often underestimated by clinicians. Symptoms may fluctuate in quality and intensity over time and commonly will vary over the course of a day. For pain, clinical signs and symptoms will be dependent on the source of the pain and whether causative underlying pathology is identifiable or not. Fatigue may range from mild effects to total exhaustion and may include cognitive and emotional elements, with a complex, probably multicausal, pathway. Theoretical knowledge of potential mechanistic pathways for pain and fatigue should be used to inform assessment and treatment approaches. Best practice recommends a multidisciplinary and holistic treatment approach with the patient an active participant in the planning of their care, and self-management. Many patients with chronic musculoskeletal conditions will not achieve a pain-free or fatigue-free status. Medication use must therefore balance potential benefit against short- and long-term side effects. Rheumatology centres should offer specific fatigue and pain self-management support as part of routine care. Emphasis should be given to facilitating self-management strategies for both pain and fatigue to help the patient optimize their quality of life over years or a lifetime of symptoms. Interventions should include behaviour change and cognitive restructuring of pain/fatigue beliefs, as well as access to relevant self-help groups and charitable organizations. Referral for specialist advice from regional or national clinics on pain relief and management should be considered if pain interferes significantly with function or quality of life despite local interventions.

Predicted burden of venous disease

2016 ◽  
Vol 31 (1_suppl) ◽  
pp. 74-79 ◽  
Author(s):  
Sarah Onida ◽  
Alun Huw Davies
Keyword(s):  
Varicose Veins ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Venous Ulceration ◽  
Increased Risk ◽  
Future Burden ◽  
Clinical Signs And Symptoms

Chronic venous disease is a common condition with clinical signs and symptoms ranging from spider veins, to varicose veins, to active venous ulceration. Both superficial and deep venous dysfunction may be implicated in the development of this disease. Socio-economic factors are shaping our population, with increasing age and body mass index resulting in significant pressure on healthcare systems worldwide. These risk factors also lead to an increased risk of developing superficial and/or deep venous insufficiency, increasing disease prevalence and morbidity. In this chapter, the authors review the current and future burden of chronic venous disease from an epidemiological, quality of life and economic perspective.

scholarly journals Classification Criteria and Clinical Practice Guidelines for Rheumatic Diseases

2021 ◽  
pp. 521-566
Author(s):  
Rola Hassan ◽  
Hanan Faruqui ◽  
Reem Alquraa ◽  
Ayman Eissa ◽  
Fatma Alshaiki ◽  
...  
Keyword(s):  
Rheumatic Diseases ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Quality Of Healthcare ◽  
Classification Criteria ◽  
Healthcare Provision ◽  
Management Guidelines ◽  
The Core ◽  
Clinical Signs And Symptoms

AbstractRheumatic diseases have many classification criteria and management guidelines that are continuously being updated in order to improve the quality of healthcare provision. With these ever-evolving criteria and guidelines, practicing clinicians need an easy way to get to the core of these updates and to retain them in an easy and memorable way. Classification criteria are meant to differentiate between similar diseases and also to confirm or rule out a certain disease based on inclusion and exclusion criteria. The diagnosis of rheumatic diseases can be challenging since many clinical signs and symptoms as well as many laboratory markers are not specific and can be positive in many diseases.

Pain and fatigue

2013 ◽  
Author(s):  
Candy McCabe ◽  
Richard Haigh ◽  
Helen Cohen ◽  
Sarah Hewlett
Keyword(s):  
Quality Of Life ◽  
Best Practice ◽  
Management Strategies ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Routine Care ◽  
Self Management ◽  
Management Support ◽  
Holistic Treatment

Pain and fatigue are the prominent problems for those with a rheumatic disease, and are often underestimated by clinicians. Symptoms may fluctuate in quality and intensity over time and commonly will vary over the course of a day. For pain, clinical signs and symptoms will be dependent on the source of the pain and whether causative underlying pathology is identifiable or not. Fatigue may range from mild effects to total exhaustion and may include cognitive and emotional elements, with a complex, probably multicausal, pathway. Theoretical knowledge of potential mechanistic pathways for pain and fatigue should be used to inform assessment and treatment approaches. Best practice recommends a multidisciplinary and holistic treatment approach with the patient an active participant in the planning of their care, and self-management. Many patients with chronic musculoskeletal conditions will not achieve a pain-free or fatigue-free status. Medication use must therefore balance potential benefit against short- and long-term side effects. Rheumatology centres should offer specific fatigue and pain self-management support as part of routine care. Emphasis should be given to facilitating self-management strategies for both pain and fatigue to help the patient optimize their quality of life over years or a lifetime of symptoms. Interventions should include behaviour change and cognitive restructuring of pain/fatigue beliefs, as well as access to relevant self-help groups and charitable organizations. Referral for specialist advice from regional or national clinics on pain relief and management should be considered if pain interferes significantly with function or quality of life despite local interventions.

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