Development and Implementation of a User-Friendly, Online Electronic System to Manage All Documents Needed for Accreditation and Point-of-Care Testing Programs

Author(s):  
Carlos Reis ◽  
Henrique Paiffer ◽  
Márcia Schiel ◽  
Flávia Campana ◽  
Kátia Regina Cesar ◽  
...  
Micromachines ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1464
Author(s):  
Florina Silvia Iliescu ◽  
Ana Maria Ionescu ◽  
Larisa Gogianu ◽  
Monica Simion ◽  
Violeta Dediu ◽  
...  

The deleterious effects of the coronavirus disease 2019 (COVID-19) pandemic urged the development of diagnostic tools to manage the spread of disease. Currently, the “gold standard” involves the use of quantitative real-time polymerase chain reaction (qRT-PCR) for SARS-CoV-2 detection. Even though it is sensitive, specific and applicable for large batches of samples, qRT-PCR is labour-intensive, time-consuming, requires trained personnel and is not available in remote settings. This review summarizes and compares the available strategies for COVID-19: serological testing, Point-of-Care Testing, nanotechnology-based approaches and biosensors. Last but not least, we address the advantages and limitations of these methods as well as perspectives in COVID-19 diagnostics. The effort is constantly focused on understanding the quickly changing landscape of available diagnostic testing of COVID-19 at the clinical levels and introducing reliable and rapid screening point of care testing. The last approach is key to aid the clinical decision-making process for infection control, enhancing an appropriate treatment strategy and prompt isolation of asymptomatic/mild cases. As a viable alternative, Point-of-Care Testing (POCT) is typically low-cost and user-friendly, hence harbouring tremendous potential for rapid COVID-19 diagnosis.


2017 ◽  
Vol 9 (27) ◽  
pp. 22252-22258 ◽  
Author(s):  
Dan Liu ◽  
Shasha Jia ◽  
Huimin Zhang ◽  
Yanli Ma ◽  
Zhichao Guan ◽  
...  

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Yansheng Li ◽  
Xiujin Men ◽  
Guowei Gao ◽  
Ye Tian ◽  
Yongqiang Wen ◽  
...  

Distance-based detection methods with quantitative readout are of great significance to point-of-care testing (POCT), which are low-cost, user-friendly and can be integrated into portable analytical devices. Here, we submit a...


Author(s):  
Hosam M Zowawi ◽  
Thamer H Alenazi ◽  
Waleed S AlOmaim ◽  
Ahmad Wazzan ◽  
Abdullah Alsufayan ◽  
...  

Combating the ongoing coronavirus disease 2019 (COVID-19) pandemic demands accurate, rapid, and point-of-care testing with fast results to triage cases for isolation and treatment. The current testing relies on RT-PCR, which is routinely performed in well-equipped laboratories by trained professionals at specific locations. However, during busy periods high numbers of samples queued for testing can delay the test results, impacting upon efforts to reduce the infection risk. Besides, the absence of well-established laboratories at remote sites and low-resourced environments can contribute to a silent spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These reasons compel the need to accommodate point-of-care testing for COVID-19 that meets the ASSURED criteria (Affordable, Sensitive, Specific, User-friendly, Rapid, robust, Equipment-free, and Deliverable). This study assessed the agreement and accuracy of the portable Biomeme SARS-CoV-2 system against the gold standard tests. Nasopharyngeal and nasal swabs were used. Of the 192 samples tested using the Biomeme SARS-CoV-2 system, the results from 189 samples (98.4%) were in agreement with the reference standard-of-care RT-PCR testing for SARS-CoV-2. The portable system generated simultaneous results for nine samples in 80 mins with high positive and negative percent agreements of 99.0% and 97.8%, respectively. We performed separate testing in a sealed glove box, offering complete biosafety containment. Thus, the Biomeme SARS-CoV-2 system can help decentralize COVID-19 testing and offer rapid test results for patients in remote and low-resourced settings. Single Sentence Summary The Biomeme SARS-CoV-2 system can help decentralize COVID-19 testing and offer rapid test results for patients in remote sites and low-resourced settings.


Lab on a Chip ◽  
2020 ◽  
Vol 20 (7) ◽  
pp. 1191-1203 ◽  
Author(s):  
Juhwan Park ◽  
Dong Hyun Han ◽  
Je-Kyun Park

An overview and future perspectives of user-friendly microfluidic devices have been reported in terms of practical sample preparation in point-of-care testing.


2017 ◽  
Vol 868 ◽  
pp. 340-344 ◽  
Author(s):  
Jin An Wang ◽  
Zhong Liang Xia ◽  
Yan Su ◽  
Min Cong Lu ◽  
Ying Wan ◽  
...  

Organophosphorous pesticide (OP), one of the most commonly used pesticides, could have serious adverse effects on human health and the environment. As the maximum residue limit (MRL) of OPs in food and water is low, it is in great demand to develop integrated, portable, user-friendly devices for the rapid and sensitive detection of OP residue. This work aims to present a homemade handhold device and screen printing electrode (SPE) chip for rapid, sensitive, and one-step detection of OPs. A handhold device was designed and fabricated to connect with smartphone to readout the electrochemical signals. Taking advantage of a three-electrode sensor chip and the inhibiting reaction of acetylcholine esterase (AchE), Trichlorphon can be detected in a considerable low detection limit of 1 ng/mL. By using the as-fabricated device and chip, the detection time was only 5 min and each test costs less than $1. The platform will allow point-of-care testing (POCT) of OPs and other targets, which shows promise for healthy and environmental monitoring.


Author(s):  
Muhammad Anas Yuzairi Mohd Yusri ◽  
Mohd Hafiz Abu Hassan ◽  
Syaza Azhari

Human chorionic gonadotropin (HCG) has been amongst of essential part of medical diagnostics in gynaecology and oncology since its discovery. Application of gold nanoparticles in detecting HCG is due to gold nanoparticles possess extraordinary optical and physical properties, making them invaluable in various prominent aspects, including its synthesis, stabilization, and functionalization as a sensor. In addition, microfluidic analytical device, a platform for point-of-care testing and numerous applications in various field, can be applied for detection of HCG using diverse types of detection methods. From the literatures, combination of gold nanoparticles and microfluidic analytical device can be assembled to obtain a rapid, simple and user-friendly analytical site for detection of HCG.


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