Fasting plasma glucose predicts traditional cardiovascular risk factors among non-diabetic subjects

ObjectiveFew studies have determined the effects of more than 5–10 years of GH replacement in adults on body composition and cardiovascular risk factors.Design/patientsIn this prospective, single-center, open-label study, the effects of 15 years of GH replacement on body composition and cardiovascular risk factors were determined in 156 hypopituitary adults (93 men) with adult-onset GH deficiency (GHD). Mean age was 50.5 (range 22–74) years at study start. Body composition was measured using dual-energy X-ray absorptiometry.ResultsThe mean initial GH dose of 0.55 (s.e.m. 0.03) mg/day was gradually lowered to 0.40 (0.01) mg/day after 15 years. The mean serum IGF1 SDS increased from −1.53 (0.10) at baseline to 0.74 (0.13) at study end (P<0.001 vs baseline). Lean soft tissue (LST) increased to 3% above the baseline level at study end (P<0.001). After a 9% decrease during the first year of treatment (P<0.001 vs baseline), body fat (BF) started to increase and had returned to the baseline level after 15 years. Serum levels of total cholesterol and LDL-cholesterol decreased and serum HDL-cholesterol level increased. Fasting plasma glucose increased from 4.4 (0.1) at baseline to 4.8 (0.1) mmol/l at study end (P<0.001). However, blood HbA1c decreased from 5.0 (0.1) to 4.6 (0.1) % (P<0.001).ConclusionsFifteen-year GH replacement in GHD adults induced a transient decrease in BF and sustained improvements of LST and serum lipid profile. Fasting plasma glucose increased whereas blood HbA1c was reduced.

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The Global, Regional, and National Burden and Trends of Breast Cancer From 1990 to 2019: Results From the Global Burden of Disease Study 2019

Frontiers in Oncology ◽

10.3389/fonc.2021.689562 ◽

2021 ◽

Vol 11 ◽

Author(s):

Shangbo Xu ◽

Yiyuan Liu ◽

Taofeng Zhang ◽

Jiehua Zheng ◽

Weixun Lin ◽

...

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Burden Of Disease ◽

Global Burden Of Disease ◽

Global Burden ◽

Fasting Plasma ◽

Life Years ◽

High Fasting Plasma Glucose

BackgroundThe burden of breast cancer has been increasing globally. The epidemiology burden and trends need to be updated. This study aimed to update the burden and trends of breast cancer incidences, deaths, and disability-adjusted life-years (DALYs) from 1990 to 2019, using the Global Burden of Disease 2019 study.MethodsThe data of incidences, deaths, DALYs, and age-standardized rates were extracted. Estimated annual percentage changes were used to quantify the trends of age-standardized rates. Besides, the population attributable fractions of the risk factors of breast cancer were also estimated.ResultsGlobally, the incidences of breast cancer increased to 2,002,354 in 2019. High social-development index (SDI) quintiles had the highest incidence cases with a declining trend in age-standardized incidence rate. In 2019, the global deaths and DALYs of breast cancer increased to 700,660 and 20,625,313, respectively. From 1990 to 2019, the age-standardized mortality rates and age-standardized DALY rates declined globally, especially in high and high-middle SDI quintiles. Besides, the trends varied from different regions and countries. The proportion of the patients in the 70+ years age group increased globally. Deaths of breast cancer attributable to high fasting plasma glucose and high body mass index increased globally, and high fasting plasma glucose was the greatest contributor to the global breast cancer deaths.ConclusionThe burden of breast cancer in higher SDI quintiles had gone down while the burden was still on the rise in lower SDI quintiles. It is necessary to appeal to the public to decrease the exposure of the risk factors.

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Risk factors for Type 2 Diabetes Mellitus in college students: association with sociodemographic variables

Revista Latino-Americana de Enfermagem ◽

10.1590/0104-1169.3053.2441 ◽

2014 ◽

Vol 22 (3) ◽

pp. 484-490 ◽

Cited By ~ 20

Author(s):

Adman Câmara Soares Lima ◽

Márcio Flávio Moura Araújo ◽

Roberto Wagner Júnior Freire de Freitas ◽

Maria Lúcia Zanetti ◽

Paulo César de Almeida ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

College Students ◽

Type 2 Diabetes ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Central Obesity ◽

Fasting Plasma ◽

High Fasting Plasma Glucose

OBJECTIVE: identify the modifiable risk factors for type 2 diabetes mellitus in college students and associate these factors with their sociodemographic variables.METHOD: cross-sectional study, involving 702 college students from Fortaleza-CE, Brazil. Sociodemographic, anthropometric, physical exercise data and blood pressure and fasting plasma glucose levels were collected.RESULTS: the most prevalent risk factor was sedentariness, followed by overweight, central obesity, high fasting plasma glucose and arterial hypertension. A statistically significant association was found between overweight and sex (p=0.000), age (p=0.004) and marital status (p=0.012), as well as between central obesity and age (p=0.018) and marital status (p=0.007) and between high fasting plasma glucose and sex (p=0.033).CONCLUSION: distinct risk factors were present in the study population, particularly sedentariness and overweight.

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