HMB-45 and Melan-A are Useful in the Differential Diagnosis Between Granular Cell Tumor and Malignant Melanoma

2007 ◽  
Vol 29 (1) ◽  
pp. 22-27 ◽  
Author(s):  
Briana C Gleason ◽  
Alessandra F Nascimento
Keyword(s):  
Differential Diagnosis ◽  
Malignant Melanoma ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Hmb 45

scholarly journals Laryngeal Granular Cell Tumor; Rare Location

2011 ◽  
Vol 54 (1) ◽  
pp. 41-43
Author(s):  
Sedat Aydın ◽  
Arif Şanlı ◽  
Özlem Çelebi ◽  
Emin Ayduran ◽  
Gecer Melin
Keyword(s):  
Differential Diagnosis ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Complete Surgical Resection ◽  
Submucosal Lesions ◽  
Neurogenic Origin ◽  
Rare Location ◽  
Posterior Glottis

Granular cell tumors are benign subcutaneous or submucosal lesions of neurogenic origin. In this case study one patient was diagnosed and treated successfully with complete surgical resection of a laryngeal granular cell tumor that was originated from the left arytenoid region that very rare location. There is no evidence of recurrence 2 years after surgery. Granular cell tumors should be considered in the differential diagnosis of laryngeal masses, particularly in the posterior glottis.

Granular Cell Tumors of the Larynx

1976 ◽  
Vol 85 (4) ◽  
pp. 504-507 ◽  
Author(s):  
Harvey L. Coates ◽  
Thomas J. McDonald ◽  
Kenneth D. Devine ◽  
Louis H. Weiland
Keyword(s):  
Squamous Cell Carcinoma ◽  
Differential Diagnosis ◽  
Cell Carcinoma ◽  
Local Excision ◽  
Squamous Cell ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Posterior Portion ◽  
Pseudoepitheliomatous Hyperplasia

Granular cell tumors of the larynx are relatively uncommon, always benign, and most commonly located in the posterior portion of the larynx. They are easily identified and should be differentiated from other lesions. A possible problem in the differential diagnosis is the presence of pseudoepitheliomatous hyperplasia, which overlies the granular cell tumor and which may mimic squamous cell carcinoma. Careful histopathologic differentiation is important because the laryngeal granular cell lesion should be managed conservatively, with transoral local excision usually being adequate. The histogenesis of these lesions remains in doubt, with a neural or epithelial derivation being the most likely possibility.

Granular cell tumor in differential diagnosis of tumors of the breast

1992 ◽  
Vol 188 (8) ◽  
pp. 1091-1094 ◽  
Author(s):  
H.J. Hahn ◽  
J. Iglesias ◽  
H. Flenker ◽  
G. Kreuzer
Keyword(s):  
Differential Diagnosis ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor

scholarly journals Neumann’s Tumor - A Rare Neonatal Tumor

2018 ◽  
Vol 7 (3) ◽  
pp. 40
Author(s):  
Ceyhan Sahin ◽  
Zeliha Akış yıldız ◽  
Aytekin Kaymakcı ◽  
Ozgül Gergin tinay
Keyword(s):  
Differential Diagnosis ◽  
Surgical Resection ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Cosmetic Appearance ◽  
The Family ◽  
Congenital Epulis ◽  
Neonatal Tumor ◽  
Congenital Granular Cell Tumor

Neumann’s tumor, also known as congenital granular cell tumor, congenital myoblastoma, congenital epulis, was first described by Neumann in 1871. It’s a rare cause of newborn’s intraoral masses. they are usually on the maxilla and soliter , they can rarely  be seen on the mandibula and multiple. Even if it is not clinically symptomatic, surgical resection is performed because of its cosmetic appearance, negative psychological effect on the family , differential diagnosis and treatment. Neumann’s tumor is fully cured by surgical resection because it does not show recurrence or metastasis after excision.

Sinus Histiocytosis With Massive Lymphadenopathy and Langerhans Cell Histiocytosis Express the Cellular Adhesion Molecule CD31

2003 ◽  
Vol 127 (3) ◽  
pp. 341-344 ◽  
Author(s):  
Stephen P. Slone ◽  
Donald R. Fleming ◽  
John J. Buchino
Keyword(s):  
Malignant Melanoma ◽  
Adhesion Molecule ◽  
Langerhans Cells ◽  
Langerhans Cell Histiocytosis ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cellular Adhesion ◽  
Cell Tumor ◽  
Langerhans Cell ◽  
Massive Lymphadenopathy

Abstract Context.—We investigated expression of the adhesion molecule CD31 in sinus histiocytosis with massive lymphadenopathy (SHML) and Langerhans cell histiocytosis (LCH) because (1) SHML and LCH cells express a variety of cellular adhesion molecules and (2) SHML has been characterized as a reactive histiocytic proliferation, and tissue macrophages (histiocytes) are known to express CD31. Objective.—The purpose of this study was to determine whether SHML and LCH cells express CD31 and whether dual staining with CD31 and S100 facilitates diagnosis of these disease states. Methods.—Formalin-fixed, paraffin-embedded archival tissues were immunohistochemically stained via the labeled streptavidin-biotin method using antibodies against CD31 and S100 protein after heat-induced epitope retrieval. Archival tissues included SHML (n = 2), LCH (n = 10), malignant melanoma (n = 5), sinus hyperplasia (n = 4), granulomas (n = 4), granular cell tumor (n = 6), and normal skin (n = 4). Results.—Normal Langerhans cells in the epidermis were CD31−/S100+; neoplastic Langerhans cells in LCH were CD31+/S100+. Histiocytes in granulomas and in sinus hyperplasia were CD31+/S100−; abnormal histiocytes in SHML were CD31+/S100+. S100+ tumors (malignant melanoma and granular cell tumor) were CD31−. Conclusions.—The spectrum of cell types that express CD31 is expanded to include SHML and LCH. We speculate that up-regulation of CD31 in neoplastic Langerhans cells contributes to the migratory capability of LCH cells. CD31 may be a useful nonlysosomal marker of macrophages and their neoplastic counterparts (true histiocytic sarcomas). An immunohistochemical staining panel that includes CD31 and S100 facilitates the diagnosis of SHML and LCH.

scholarly journals Case for diagnosis

2013 ◽  
Vol 88 (3) ◽  
pp. 469-471
Author(s):  
Amanda Gomes Dell'Horto ◽  
Jackson Machado Pinto ◽  
Michelle dos Santos Diniz
Keyword(s):  
Differential Diagnosis ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Skin Lesions ◽  
Benign Disease ◽  
Cell Tumor ◽  
Solitary Nodule ◽  
Unusual Location

Granular cell tumor (Abrikossoff's tumor) is a rare benign disease that preferentially affects the cervicofacial segment. It is usually a solitary nodule that may ulcerate and present pearly infiltration on the borders, while keeping a clean background and a hyperchromic halo. This paper describes the case of an ulcerated granular cell tumor on an unusual location, which reinforces the necessity of including this tumor in the differential diagnosis of nodular-ulcerative skin lesions.

Granular Cell Tumor as a Differential Diagnosis of Suprasellar Mass: A Case Report.

2010 ◽  
pp. P3-298-P3-298
Author(s):  
TP Sickler ◽  
A Glezer ◽  
D Vicaria ◽  
W Cescato ◽  
S Rosemberg ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor

scholarly journals Ulcerative Granular Cell Tumor: A Clinicopathological and Immunohistochemical Study

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Mohamed El-Khalawany ◽  
Al-Sadat Mosbeh ◽  
Fatma Abd-Al Salam ◽  
Amany Abou-Bakr
Keyword(s):  
Differential Diagnosis ◽  
Granular Cell Tumor ◽  
Immunohistochemical Study ◽  
Granular Cell ◽  
Cell Tumor ◽  
Granular Cytoplasm ◽  
Solitary Ulcer ◽  
Cutaneous Ulcer ◽  
Ulcerative Lesions ◽  
Dermal Infiltrate

Granular cell tumor (GCT) is uncommonly presented with cutaneous ulcer. We examined the clinicopathological and immunohistochemical features of this ulcerative form in fourteen cases that may raise the awareness of this variant. The study included 11 males and 3 females with a mean age 31.5 ± 7.42 years. All cases were presented with large solitary ulcer with indurated base, elevated border, skin colored margin, and necrotic floor. Twelve lesions were located on the extremities and two lesions on the genital region. Histologically, the lesions showed dermal infiltrate composed of large polygonal cells with granular cytoplasm and characteristic infiltration of the dermal muscles in all cases. Immunostaining showed positive reaction for S100 (14/14), NSE (14/14), CD68 (5/14), and Vimentin (7/14) while HMB45, CK, EMA, and Desmin were negative. We hope that this paper increases the awareness of ulcerative GCT and consider it in the differential diagnosis of ulcerative lesions.

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