[PP.02.13] EFFECT OF COMBINATION DRUG (ARB IRBESARTAN 100MG PULAS CA-ANTAGONIST AMLODIPINE 5MG OR 10MG) ON HYPERTENSIVE PATIENTS

Objective: In South Asia, hypertension is the third highest factor contributing in public health burden of disease and major risk factor for coronary artery disease especially in women and old age people. The study was aimed to determine the role of gender and age (20–80 years) on severity of hypertension to design an effective schedule for management of hypertension. Methods: The levels of serum cholesterol, triglycerides (TG), high-density lipoprotein (HDL), low-density lipoproteins (LDL), and blood pressure (BP) of 240 hypertensive patients were monitored. Cholesterol, TG, and HDL levels were detected using ERBA Reagent kit of Transasia Bio-medicals LTD by CHOD-PAP, glycerol phosphate oxidase trinder End point, and polyvinyl sulfonic and polyethyleneglycol-methyl ether based methods, respectively. Results: The BP and levels of serum cholesterol, TG and LDL were increased in both the genders after 40 years of age. However, the rise in levels of these parameters was more in females in comparison to males. A hypertension management schedule involving (BP)/Cholesterol lowering drugs and lifestyle changes for period of 60 days showed that combination drug therapy was more effective than monotherapies of same drugs used at higher dosages. Conclusion: Hypertensive patients strictly followed the prescribed healthy food and exercise schedule showed improvement in their BP and lipid profile even with limited drug intervention.

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EVALUATION OF PRESCRIBING PATTERN OF FIXED DOSE COMBINATIONS OF ANTIHYPERTENSIVES AND ANTIDIABETIC AGENTS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i9.18966 ◽

2017 ◽

Vol 10 (9) ◽

pp. 164 ◽

Cited By ~ 1

Author(s):

Niyati Devangkumar Vyas ◽

Alpa P Gor ◽

Jalpa V Suthar

Keyword(s):

Descriptive Analysis ◽

Fixed Dose ◽

Diabetic Patients ◽

Normal Range ◽

Combination Drug ◽

Prescribing Pattern ◽

Antidiabetic Agents ◽

Hypertensive Patients ◽

Demographical Data ◽

Positive Results

Objective: The objective of this research was to evaluate prescribing pattern of fixed dose combinations (FDCs) of antihypertensives and antidiabetic agents among patients of private hospitals.Methods: An observational study was carried out in the outpatient department of two hospitals. Data of patients being diagnosed with the symptoms of hypertension and diabetes were enrolled which mainly included information related to prescribe FDCs, i.e., antihypertensives and antidiabetics, respectively. Descriptive analysis of collected information was done which involved representation of demographical data, number of comorbidities, number of FDCs prescribed, and type of FDCs consequently.Results: Combination drug therapy was prescribed in maximum patients, which was enumerated as 93% among hypertensive patients and about 91% in diabetics. Average age of patients suffering more from hypertension was 64.5±18 years and that in case of diabetes sufferers was 54.5±18 years. The most frequent combination prescribed in hypertensive patients was of angiotensin receptor blocker (ARB) and calcium channel blocker (CCB) which were about 53%, and in diabetic patients, it was of biguanides and sulfonylureas about 63%. Comorbidity too was notified, and its estimation was 61% in hypertensive patients and 72% in diabetic patients, respectively.Conclusion: The study here demonstrates that the most often prescribed antihypertensive combination is of ARB and CCB, and subsequently for diabetes, the oral hypoglycemic combination is of biguanides and sulfonylureas. Most of FDCs contained medications of these two classes. Positive results were also observed in levels of blood pressure and glucose within the normal range.

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