scholarly journals Physical activity, C-reactive protein levels and the risk of future coronary artery disease in apparently healthy men and women: the EPIC–Norfolk prospective population study

Author(s):  
S. Matthijs Boekholdt ◽  
Manjinder S. Sandhu ◽  
Nicholas E. Day ◽  
Robert Luben ◽  
Sheila A. Bingham ◽  
...  
2005 ◽  
Vol 94 (11) ◽  
pp. 1048-1053 ◽  
Author(s):  
Ramzi Ajjan ◽  
Timothy Futers ◽  
Jane Brown ◽  
Charlotte Cymbalista ◽  
May Boothby ◽  
...  

SummaryThe aim of this study was to determine whether complement C3 is an indicator of coronary artery disease (CAD). We measured plasma C3 and CRP levels in 278 patients undergoing coronary angiography for typical symptoms of CAD and 269 healthy age and sex matched controls. C3 levels were significantly higher in patients compared with controls (1.15 g/l and 0.92 g/l respectively; p<0.001). In the patient group, C3 levels correlated with BMI, fasting glucose, HbA1c, fibrinogen, CRP and HDL in both men and women. CRP levels were also higher in patients compared with controls (1.14 mg/l and 0.86 mg/l respectively; p=0.005) and correlated with markers of the metabolic syndrome. In a logistic regression model including C3, smoking, hypertension, cholesterol and diabetes, C3 was independently associated with CAD with an odds ratio of 3.20 for a 1 SD increase in C3 levels. In contrast, CRP was not independently associated with CAD in a similar regression analysis. In conclusion, both C3 and CRP plasma levels are elevated in patients with symptoms of CAD. However, C3 seems to be a better indicator of CAD than CRP in this study, suggesting that C3 could be an additional marker for risk stratification in atherosclerosis.


2005 ◽  
Vol 26 (20) ◽  
pp. 2099-2105 ◽  
Author(s):  
Fabrizio Tomai ◽  
Flavio Ribichini ◽  
Anna S. Ghini ◽  
Valeria Ferrero ◽  
Giuseppe Andò ◽  
...  

2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Maria Udeanu ◽  
Giordano Guizzardi ◽  
Giuseppe Di Pasquale ◽  
Antonio Marchetti ◽  
Francesca Romani ◽  
...  

Circulation ◽  
2000 ◽  
Vol 102 (9) ◽  
pp. 1000-1006 ◽  
Author(s):  
Stephan Fichtlscherer ◽  
Gunter Rosenberger ◽  
Dirk H. Walter ◽  
Susanne Breuer ◽  
Stefanie Dimmeler ◽  
...  

Circulation ◽  
2012 ◽  
Vol 125 (12) ◽  
pp. 1482-1490 ◽  
Author(s):  
David Melzer ◽  
Nicholas J. Osborne ◽  
William E. Henley ◽  
Riccardo Cipelli ◽  
Anita Young ◽  
...  

2000 ◽  
Vol 85 (2) ◽  
pp. 140-146 ◽  
Author(s):  
Jianhui Zhu ◽  
Arshed A Quyyumi ◽  
James E Norman ◽  
Gyorgy Csako ◽  
Myron A Waclawiw ◽  
...  

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