Investigation of Corneal Effect of Different Types of Artificial Tears in a Simulated Dry Eye Condition Using a Novel Porcine Dry Eye Model (pDEM)

Cornea ◽  
2006 ◽  
Vol 25 (10) ◽  
pp. 1200-1204 ◽  
Author(s):  
Emily Pik Yin Choy ◽  
Pauline Cho ◽  
Iris Frances Forster Benzie ◽  
Camus Kar Man Choy
Keyword(s):  
Dry Eye ◽  
Artificial Tears ◽  
Eye Model ◽  
Different Types

scholarly journals Efficacy of Artificial Tears Based on an Extract of Artemia salina Containing Dinucleotides in a Rabbit Dry Eye Model

2021 ◽  
Vol 22 (21) ◽  
pp. 11999
Author(s):  
Carlos Carpena-Torres ◽  
Jesus Pintor ◽  
Fernando Huete-Toral ◽  
Alba Martin-Gil ◽  
Candela Rodríguez-Pomar ◽  
...  
Keyword(s):  
Dry Eye ◽  
Randomized Study ◽  
Goblet Cells ◽  
Artemia Salina ◽  
Mrna Levels ◽  
Artificial Tears ◽  
Conjunctival Hyperemia ◽  
Eye Model ◽  
Beneficial Effects ◽  
High Concentrations

(1) Background: Artemia salina is a brine shrimp containing high concentrations of dinucleotides, molecules with properties for dry eye treatment. For this reason, the purpose of the study was to evaluate the effect of the artificial tears based on an extract of Artemia salina in a rabbit dry eye model. (2) Methods: A prospective and randomized study was carried out. Twenty rabbits were divided into 4 groups (n = 5, each group): healthy rabbits, dry eye rabbits, dry eye rabbits treated with hypromellose (HPMC), and dry eye rabbits treated with Artemia salina. Dry eye was induced by the topical instillation of 0.2% benzalkonium chloride. The measurements were performed before and after the treatment for 5 consecutive days. (3) Results: The topical instillation of artificial tears containing Artemia salina showed beneficial effects on tear secretion, tear break-up time, corneal staining, the density of Goblet cells, heigh of mucin cloud secreted by these cells, and mRNA levels of IL-1β and MMP9 in conjunctival cells. Compared with the HPMC, there was a statistically significant improvement (p < 0.05) with the Artemia salina in all the variables under study, except for the conjunctival hyperemia, density of Goblet cells, and mRNA levels of IL-6. (4) Conclusions: The potential of artificial tears based on Artemia salina as a secretagogue agent for dry eye treatment was confirmed, opening the door for future clinical trials and studies to extrapolate the findings for dry eye patients.

scholarly journals Effect of persimmon leaves (Diospyros kaki) on goblet cell density and inflammation in experimental dry eye model

2020 ◽  
Vol 63 (1) ◽  
Author(s):  
Kyung-A Kim ◽  
Chung Hyun Lee ◽  
Tae Kyeom Kang ◽  
Sung Jae Yang ◽  
Chang Yong Lee ◽  
...  
Keyword(s):  
Cell Density ◽  
Dry Eye ◽  
Goblet Cell ◽  
Diospyros Kaki ◽  
Eye Model ◽  
Goblet Cell Density

Effectiveness of Artificial Tears in the Management of Evaporative Dry Eye

Cornea ◽  
2012 ◽  
Vol 31 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Louise C McCann ◽  
Alan Tomlinson ◽  
Edward I Pearce ◽  
Vincenzo Papa
Keyword(s):  
Dry Eye ◽  
Artificial Tears ◽  
Evaporative Dry Eye

Lágrimas artificiais no tratamento da doença do olho seco: uma revisão de literatura/ Artificial tears in the treatment of dry eye disease: a literature review

2021 ◽  
Vol 7 (7) ◽  
pp. 65512-65533
Author(s):  
Rafaela Montenegro Aires Sampaio ◽  
Anyssa Brilhante Aires Montenegro ◽  
Claudia Roberta de Andrade
Keyword(s):  
Literature Review ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Artificial Tears

Effect of artificial tears on automated visual field testing in patients with glaucoma and dry eye

2013 ◽  
Vol 48 (2) ◽  
pp. 110-114 ◽  
Author(s):  
Sibel Kocabeyoglu ◽  
Mehmet Cem Mocan ◽  
Banu Bozkurt ◽  
Murat Irkec
Keyword(s):  
Visual Field ◽  
Dry Eye ◽  
Field Testing ◽  
Visual Field Testing ◽  
Artificial Tears

scholarly journals Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

10.3791/60126 ◽  
2020 ◽  
Author(s):  
Robert A. Honkanen ◽  
Liqun Huang ◽  
Wei Huang ◽  
Basil Rigas
Keyword(s):  
Dry Eye ◽  
Eye Model

Impact of Nanostructured Lipid Carriers as an Artificial Tear Film in a Rabbit Evaporative Dry Eye Model

Cornea ◽  
2019 ◽  
Vol 38 (4) ◽  
pp. 485-491 ◽  
Author(s):  
Pattravee Niamprem ◽  
Pronnarin Teapavarapruk ◽  
Sangly P. Srinivas ◽  
Waree Tiyaboonchai
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Nanostructured Lipid Carriers ◽  
Artificial Tear ◽  
Eye Model ◽  
Evaporative Dry Eye

scholarly journals Mucoadhesive Bletilla striata Polysaccharide-Based Artificial Tears to Relieve Symptoms and Inflammation in Rabbit with Dry Eyes Syndrome

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1465 ◽  
Author(s):  
Minal Thacker ◽  
Ching-Li Tseng ◽  
Chih-Yen Chang ◽  
Subhaini Jakfar ◽  
Hsuan Yu Chen ◽  
...  
Keyword(s):  
Physical Properties ◽  
Dry Eye ◽  
Ocular Surface ◽  
Close Association ◽  
Term Treatment ◽  
Artificial Tears ◽  
Dry Eyes ◽  
Bletilla Striata ◽  
Long Term Treatment ◽  
Anti Inflammatory

Dry eye syndrome (DES) is a multifactorial disorder of the ocular surface affecting many people all over the world. However, there have been many therapeutic advancements for the treatment of DES, substantial long-term treatment remains a challenge. Natural plant-based polysaccharides have gained much importance in the field of tissue engineering for their excellent biocompatibility and unique physical properties. In this study, polysaccharides from a Chinese ground orchid, Bletilla striata, were successfully extracted and incorporated into the artificial tears for DES treatment due to its anti-inflammatory and mucoadhesive properties. The examination for physical properties such as refractive index, pH, viscosity and osmolality of the Bletilla striata polysaccharide (BSP) artificial tears fabricated in this study showed that it was in close association with that of the natural human tears. The reactive oxygen species (ROS) level and inflammatory gene expression tested in human corneal epithelium cells (HCECs) indicated that the low BSP concentrations (0.01–0.1% v/v) could effectively reduce inflammatory cytokines (TNF, IL8) and ROS levels in HCECs, respectively. Longer retention of the BSP-formulated artificial tears on the ocular surface is due to the mucoadhesive nature of BSP allowing lasting lubrication. Additionally, a rabbit’s DES model was created to evaluate the effect of BSP for treating dry eye. Schirmer test results exhibited the effectiveness of 0.1% (v/v) BSP-containing artificial tears in enhancing the tear volume in DES rabbits. This work combines the effectiveness of artificial tears and anti-inflammatory herb extract (BSP) to moisturize ocular surface and to relieve the inflammatory condition in DES rabbit, which further shows great potential of BSP in treating ocular surface diseases like DES in clinics in the future.

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