Abstract
Objective: To investigate the correlation between the expression of RNA binding motif protein 3 (RBM3) in non-small cell lung cancer (NSCLC) pathological tissue and known risk factors. Methods: A retrospective analysis of the clinical and pathological features of 128 patients with NSCLC from August 1, 2014 to August 1, 2015 was performed. The expression of RBM3 and protein kinase B (AKT) in the tumor stroma was examined by immunohistochemistry and pathological enumeration, followed by analysis of its correlation with prognosis. The survival status of patients was followed up. The relationships between RBM3 and AKT protein expression in tumor stroma with overall survival (OS) and progression-free survival (PFS) were evaluated. Results: The expression of RBM3 was significantly correlated with tumor differentiation ( P =0.012), lymph node metastasis ( P =0.02), T staging ( P =0.041), and AKT expression ( P =0.021). Univariate Kaplan-Meier analysis showed that high expression of RBM3, lymph node metastasis, T staging, and high expression of AKT were prognostic factors in NSCLC ( P <0.05). Multivariate analysis of Cox proportional hazard model showed that high RBM3 expression, lymph node metastasis, and high AKT expression were independent risk factors for prognosis ( P <0.05). Conclusion: RBM3, AKT, and lymph node metastasis are independent prognostic factors for NSCLC, significantly affecting the prognosis of patients possibly through the classical signaling pathway AKT. RBM3 may be a prognostic marker for the overall survival rate of NSCLC and a candidate for the treatment of NSCLC, with potential therapeutic prospects.
A6-04: Expression of vascular endothelial growth factors (VEGFs) A, C, D and receptors (VEGFRs) 1, 2 and 3, in both tumor cells and tumor stroma of non-small cell lung cancer (NSCLC): correlation with lymph node metastasis
