Clinical Research Network Launches TONIC Trial for Treatment of Nonalcoholic Fatty Liver Disease in Children

2006 ◽  
Vol 42 (2) ◽  
pp. 129-130 ◽  
Author(s):  
Joel E Lavine ◽  
Jeffrey B Schwimmer
Keyword(s):  
Liver Disease ◽  
Clinical Research ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Research Network ◽  
Nonalcoholic Fatty Liver ◽  
Clinical Research Network

scholarly journals Quality of life in adults with nonalcoholic fatty liver disease: Baseline data from the nonalcoholic steatohepatitis clinical research network

Hepatology ◽  
2009 ◽  
Vol 49 (6) ◽  
pp. 1904-1912 ◽  
Author(s):  
Kristin David ◽  
Kris V. Kowdley ◽  
Aynur Unalp ◽  
Fasiha Kanwal ◽  
Elizabeth M. Brunt ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Liver Disease ◽  
Clinical Research ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Nonalcoholic Steatohepatitis ◽  
Fatty Liver Disease ◽  
Research Network ◽  
Nonalcoholic Fatty Liver

scholarly journals Vitamin D levels and liver histological alterations in children with nonalcoholic fatty liver disease

2014 ◽  
Vol 170 (4) ◽  
pp. 547-553 ◽  
Author(s):  
Valerio Nobili ◽  
Valentina Giorgio ◽  
Daniela Liccardo ◽  
Giorgio Bedogni ◽  
Giuseppe Morino ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Linear Regression ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Research Network ◽  
Mineral Density ◽  
Serum Aminotransferase ◽  
Nonalcoholic Fatty Liver

ObjectiveTo investigate the association between plasma vitamin D (VD) levels and histological liver damage in children with nonalcoholic fatty liver disease (NAFLD).Subjects and methodsIn this cross-sectional study, carried out in a tertiary care center for obesity, 73 consecutive overweight and obese children with persistently elevated serum aminotransferase levels and diffusely hyperechogenic liver on ultrasonography were selected for liver biopsy. Nonalcoholic steatohepatitis (NASH) and fibrosis were histologically diagnosed using NAFLD Clinical Research Network (CRN) criteria. The plasma levels of 25-OH-VD were measured by HPLC. Bone mineral density (BMD) of lumbar spine was evaluated by dual-energy X-ray absorptiometry. Multiple linear regression analysis was used to evaluate the association between 25-OH-VD levels and the predictors of interest after correction for age, gender, waist circumference, BMI, and other potential confounders.ResultsThe children (64% males) were aged 8–18 years, and their median BMI was 2.45 SDS. Both parathyroid hormone levels and BMD were within the normal range. All cases of fibrosis were detected in children with NASH. On multivariable linear regression with correction for age, gender, and BMI, 25-OH-VD levels were found to be 9 (95% CI 12–6) ng/ml lower in children with NASH than in those without NASH (P<0.001) and 9 (12–6) ng/ml lower in children with stage 1 fibrosis than in those with stage 0 fibrosis and 9 (13–6) ng/ml lower in children with stage 2 than in those with stage 0 fibrosis (P<0.001 for both).ConclusionVD levels are inversely associated with NASH and fibrosis in children with NAFLD.

scholarly journals Sex Hormone Relations to Histologic Severity of Pediatric Nonalcoholic Fatty Liver Disease

2020 ◽  
Vol 105 (11) ◽  
Author(s):  
Noel T Mueller ◽  
Tiange Liu ◽  
Elana B Mitchel ◽  
Katherine P Yates ◽  
Ayako Suzuki ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Children And Adolescents ◽  
Nonalcoholic Fatty Liver Disease ◽  
Sex Hormones ◽  
Nonalcoholic Steatohepatitis ◽  
Fatty Liver Disease ◽  
The United States ◽  
Research Network ◽  
Nonalcoholic Fatty Liver

Abstract Context Sex hormones have been linked with presence and severity of nonalcoholic fatty liver disease (NAFLD) in adults, but it is unknown if they affect severity of pediatric NAFLD. Objective To examine associations of circulating SHBG, estrogens, and androgens with key histologic features of pediatric, biopsy-confirmed NAFLD. Design Baseline assessment of longitudinal cohorts and randomized clinical trials. Setting Nonalcoholic Steatohepatitis Clinical Research Network. Patients Children and adolescents ≤18 years with liver biopsy-confirmed NAFLD in the United States. Main Outcome Measures We assayed SHBG, estrone, estradiol, dehydroepiandrosterone (DHEAS), androstenedione, and testosterone in relation to grade/stage of steatosis, portal inflammation, hepatic ballooning, fibrosis, and nonalcoholic steatohepatitis (NASH) severity using linear regression. Results Mean age of 573 children at the time of biopsy was 13.1 years (SD 2.8). Lower SHBG was inversely associated with steatosis severity in boys and girls (P = 0.001), and with portal inflammation in girls only (P for sex interaction &lt;0.001). Higher testosterone was related to improved features of steatosis and fibrosis (P for sex interaction = 0.003 and 0.01, respectively) in boys, but detrimental in girls. In boys and girls, higher estrone, estradiol, and testosterone were associated with lower portal inflammation grade; higher estradiol was positively associated with hepatic ballooning severity; DHEAS was inversely associated with hepatic ballooning and NASH severity (all P &lt; 0.05). Androstenedione was not associated with NAFLD features. Conclusions Largely consistent with findings in adults, sex hormones are associated with distinct histologic features of NAFLD in children and adolescents. These hormone levels relate to differences with gender and pubertal change.

scholarly journals Histological Scoring for Nonalcoholic Fatty Liver Disease – A Study in 55 Cases

2014 ◽  
Vol 14 (2) ◽  
pp. 114-118
Author(s):  
Rehana Khanam ◽  
Muhammad Kamal ◽  
Fauzia Jahan ◽  
P. K. Ghosh
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Nonalcoholic Steatohepatitis ◽  
Fatty Liver Disease ◽  
Morphological Changes ◽  
Research Network ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Nonalcoholic Fatty Liver

Background: Steatohepatitis is a pattern of liver injury that may be seen in alcoholic or nonalcoholic liver disease. This morphological changes may occur with obesity, diabetes, the use of certain drugs or it may be idiopathic. The main histopathological features of nonalcoholic steatohepatitis (NASH) include hepatocellular steatosis and ballooning, mixed acute and chronic lobular inflammation and fibrosis. The recently developed histological scoring system for NAFLD by the NASH Clinical Research Network (NASH CRN) is becoming increasingly popular. The  purpose of this study was to develop grading andstaging system and was  based on liver biopsies from 50 patients with Nonalcoholic Steatohepatitis from BSMMU and other clinics of Dhaka city.Objective: This study was done to analyze the histological spectrum and to develop grading and staging system in patients with nonalcoholic fatty liver disease.Methods: This cross sectional study was carried out at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. A total of 55 patients with non-alcoholic fatty liver disease (NAFLD) who fulfilled the inclusion criteria were selected for the study. Liver biopsy was done at hepatology department of BSMMU, and different clinics of the Dhaka City from july 2006 to june 2007. The data of patients along with   histopathological reports were studied.Results: Out of total 55 cases of Nonalcoholic Fatty Liver Disease 33 were male (63.63%) and 22 were female (40%). Mean age of the patient was 37.81±10.80 years. 35 (63.63%) patients were obese. 2 patients (3.63%) were diabetic. Among 55 patients NAFL (steatosis) were diagnosed in 6 patients (10.90%) and NASH in 49 patients (89.09%). Forty two (16.36%) of the 46 Definite NASH biopsy specimen exhibited fibrosis and three had cirrhosis.DOI: http://dx.doi.org/10.3329/jom.v14i2.19638 J Medicine 2013, 14(2): 114-118

scholarly journals NASH and Systemic Complications: From Basic to Clinical Research

Biomedicines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1913
Author(s):  
Sabine Baumgartner ◽  
Ronit Shiri-Sverdlov
Keyword(s):  
Metabolic Syndrome ◽  
Liver Disease ◽  
Clinical Research ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Nonalcoholic Steatohepatitis ◽  
Fatty Liver Disease ◽  
Systemic Complications ◽  
Nonalcoholic Fatty Liver ◽  
The Metabolic Syndrome

Nonalcoholic fatty liver disease (NAFLD) is known as the hepatic manifestation of the metabolic syndrome, and while most patients develop simple steatosis, up to one-third can develop nonalcoholic steatohepatitis (NASH). [...]

scholarly journals Nonalcoholic fatty liver disease: An agenda for clinical research

Hepatology ◽  
2002 ◽  
Vol 35 (4) ◽  
pp. 746-752 ◽  
Author(s):  
Zobair M. Younossi ◽  
Anna Mae Diehl ◽  
Janus P. Ong
Keyword(s):  
Liver Disease ◽  
Clinical Research ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver
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