scholarly journals Association of Histologic Chorioamnionitis With Perinatal Brain Injury and Early Childhood Neurodevelopmental Outcomes Among Preterm Neonates

2018 ◽  
Vol 73 (11) ◽  
pp. 621-623
Author(s):  
Daniel Bierstone ◽  
Nienke Wagenaar ◽  
Dawn L. Gano ◽  
Ting Guo ◽  
Gregory Georgio ◽  
...  
Keyword(s):  
Early Childhood ◽  
Brain Injury ◽  
Preterm Neonates ◽  
Perinatal Brain Injury ◽  
Neurodevelopmental Outcomes ◽  
Histologic Chorioamnionitis

scholarly journals Late-Onset Sepsis in Preterm Neonates is Associated with Higher Risks of Cerebellar Hemorrhage and Lower Motor Scores at 3 Years of Age

2021 ◽  
Author(s):  
Mais Kartam ◽  
Alia Embaireeg ◽  
Shahad Albalool ◽  
Awrad Almesafer ◽  
Majeda Hammoud ◽  
...  
Keyword(s):  
Brain Injury ◽  
Early Onset ◽  
Late Onset ◽  
Preterm Neonates ◽  
Klebsiella Pneumonia ◽  
Neurodevelopmental Outcomes ◽  
Cerebellar Hemorrhage ◽  
Late Onset Sepsis ◽  
Early Onset Sepsis ◽  
The Impact

Background: Sepsis is associated with adverse neonatal outcomes, including diffuse white matter injury (WMI) which may predispose to developmental delay. Objective: To evaluate the impact of late-onset sepsis (LOS) in preterm infants on brain injury and neurodevelopmental outcomes at 36 months corrected age (CA). Design: Retrospective cohort study. Setting: Neonatal Sepsis Registry at Neonatal Department, Al-Sabah Maternity hospital, Kuwait. Participants: A total of 203 neonates (gestational age (GA) between 24-32 weeks) were admitted between January 2017 and December 2017. Neonates were stratified into no sepsis, into early-onset sepsis (first onset of sepsis ≤72 hours postnatally), and LOS (>72 hours postnatally) 2 Main outcome: Brain injury and neurodevelopmental outcomes at 36 months CA were evaluated using Miller score and Bayley-III scales of infant development, respectively. Results: Sixteen neonates had early-onset sepsis with Klebsiella pneumonia and group-B streptococcus, and 93 developed LOS with K. pneumonia and gram-positive cocci in clusters. Intraventricular hemorrhage (n=68) and WMI (n=42) showed no group-wise differences. Higher cerebellar hemorrhage risk (adjusted odds ratio=4.6 (1.3-18.6); p=0.03) and lower motor composite scores (adjusted β=-9.5 (-16.4 to -2.7); p=0.007) were observed with LOS. Conclusions: LOS in preterm neonates is a significant risk factor predisposing to cerebellar hemorrhage and lower motor scores by three years of age.

scholarly journals A.07 Head circumference in preterm neonates: size at birth and postnatal growth predict neurodevelopment at 18 months

2016 ◽  
Vol 43 (S2) ◽  
pp. S8-S9
Author(s):  
T Selvanathan ◽  
V Chau ◽  
R Brant ◽  
A Synnes ◽  
R Grunau ◽  
...  
Keyword(s):  
Intensive Care ◽  
Brain Injury ◽  
Head Circumference ◽  
Neonatal Intensive Care ◽  
Neurodevelopmental Outcome ◽  
Postnatal Growth ◽  
Preterm Neonates ◽  
Neurodevelopmental Outcomes ◽  
Postnatal Infection ◽  
The Relationship

Background: We determined the association between head circumference (HC) at birth and through neonatal intensive care with neurodevelopmental outcome in preterm neonates, accounting for brain injury on MRI. Methods: 169 neonates born 24-32 weeks gestation were studied prospectively with serial MRI. HC was measured at birth and discharge from neonatal intensive care. Outcome was assessed at 18 months corrected age using Bayley Scales of Infant & Toddler Development III motor and cognitive scores. Using multivariate linear regressions we evaluated the association between HC and outcomes, accounting for severity of brain injury and postnatal infection. Results: 46 neonates had HC <10th percentile at birth (SHC) which predicted poorer motor (~4 points; p=0.001) and cognitive (~4 points; p=0.005) outcomes, relative to those with normal HC at birth. In 9 of these neonates, SHC persisted to discharge; they had dramatically lower motor scores (15 points; p=0.004) and cognitive scores (12 points; p<0.001), even after adjusting for known risk factors Those born with SHC whose HC normalized by discharge did not show significantly poorer outcomes than those born with normal HC. Conclusions: The relationship between small HC at birth and adverse neurodevelopmental outcomes can be attenuated with normalization of head growth through the period of neonatal intensive care.

Outcome at Age Five Years or Older for Children with Perinatal Brain Injury Treated with Neurohabilitation or Neurodevelopmental Therapy

2019 ◽  
Author(s):  
Nicol&aacute;s Gar&oacute;falo-G&oacute;mez ◽  
Jes&uacute;s Barrera-Res&eacute;ndiz ◽  
Mar&iacute;a Elena Ju&aacute;rez-Col&iacute;n ◽  
Mar&iacute;a del Consuelo Pedraza-Aguilar ◽  
Cristina Carrillo-Prado ◽  
...  
Keyword(s):  
Brain Injury ◽  
Perinatal Brain Injury

The clinical utility of the Children’s Communication Checklist-2 in children with early childhood traumatic brain injury

2020 ◽  
pp. 1-18
Author(s):  
Allison P. Fisher ◽  
Lisa M. Gies ◽  
Leah Chapman ◽  
Jessica M. Aguilar ◽  
Keith Owen Yeates ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Early Childhood ◽  
Brain Injury ◽  
Clinical Utility

scholarly journals 299 PRE-084, A Sigma-1 Receptor Ligand, Protects Against Excitotoxic Perinatal Brain Injury in Newborn Mice

2012 ◽  
Vol 97 (Suppl 2) ◽  
pp. A87-A88
Author(s):  
E. Griesmaier ◽  
A. Posod ◽  
M. Gross ◽  
V. Neubauer ◽  
K. Wegleiter ◽  
...  
Keyword(s):  
Brain Injury ◽  
Perinatal Brain Injury ◽  
Receptor Ligand ◽  
Newborn Mice ◽  
Sigma 1 Receptor ◽  
Sigma 1

Early Childhood Neurodevelopmental Outcomes in Infants Exposed to Infectious Syphilis In Utero

2018 ◽  
Vol 37 (6) ◽  
pp. 576-579 ◽  
Author(s):  
Valsan P. Verghese ◽  
Leonora Hendson ◽  
Ameeta Singh ◽  
Tamara Guenette ◽  
Jennifer Gratrix ◽  
...  
Keyword(s):  
Early Childhood ◽  
In Utero ◽  
Neurodevelopmental Outcomes

Abstract TP406: Ipsilesional Myelination is Impaired in Children With Perinatal Arterial Stroke

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Sabrina Yu ◽  
Helen Carlson ◽  
Adam Kirton
Keyword(s):  
Brain Injury ◽  
Neurological Disorders ◽  
Repeated Measures ◽  
Population Based ◽  
T Test ◽  
Biological Processes ◽  
Typically Developing ◽  
Inclusion Criteria ◽  
Perinatal Brain Injury ◽  
Perinatal Stroke

Introduction: Stroke is a leading cause of perinatal brain injury and cerebral palsy. Current therapeutic efforts focus on optimizing developmental curves but the biological processes dictating these outcomes are poorly understood. Alterations in myelination are recognized as a major determinant of outcome in preterm brain injury but are unexplored in perinatal stroke (PS). Hypothesis: Ipsilesional delays in myelination occur in children with PS and are associated with poor developmental outcome. Methods: Participants were identified through the Alberta Perinatal Stroke Project, a population-based research cohort. Inclusion criteria were: 1) MRI-confirmed, unilateral arterial PS, 2) T1-weighted MRI >6mo, 3) absence of other neurological disorders, 4) neurological outcome (Pediatric Stroke Outcome Measure, PSOM), and 5) motor assessments (Assisting Hand Assessment, AHA; Melbourne Assessment). FreeSurfer software measured hemispheric asymmetry in myelination intensity. A second method using ImageJ validated the detection of myelination asymmetry. Overall PSOM scores were classified as poor (>1) or not. Repeated measures ANOVA compared perilesional, ipsilesional remote, and contralesional homologous regions. Myelination ratios for stroke cases were compared to typically developing controls (t-test), PSOM scores (t-test), and motor assessments (Pearson’s correlation). Results: Nineteen arterial stroke cases (mean age: 13.73±4.0yo) and 27 controls (mean age: 12.52±3.7yo) were studied. Stroke cases showed a greater degree of asymmetry with lower myelination in the lesioned hemisphere, compared to controls (p<0.001). Myelination in perilesional regions was decreased compared to ipsilesional remote (p<0.001) and contralesional homologous areas (p<0.001). Ipsilesional remote regions were decreased compared to homologous regions on the contralesional hemisphere (p=0.009). Contralesional myelination was also less than controls (p<0.001). Myelination ratios were not associated with PSOM, AHA, or Melbourne scores (p=0.144, 0.218, 0.366 respectively). Conclusion: Myelination of uninjured brain in the lesioned hemisphere is altered in children with PS. Further study is required to determine clinical significance.

Antenatal corticosteroids and neurodevelopmental outcomes in late preterm births

2021 ◽  
pp. fetalneonatal-2021-322152
Author(s):  
Amir Aviram ◽  
Kellie Murphy ◽  
Sarah McDonald ◽  
Elizabeth Asztalos ◽  
Arthur Zaltz ◽  
...  
Keyword(s):  
Birth Weight ◽  
Neonatal Resuscitation ◽  
Late Preterm ◽  
Preterm Neonates ◽  
Neurocognitive Disorder ◽  
Antenatal Corticosteroids ◽  
Neurodevelopmental Outcomes ◽  
Increased Risk ◽  
Visual Testing

ObjectivesAntenatal corticosteroids (ACS) decrease neonatal mortality and morbidity among preterm neonates, yet there has been concern regarding their long-term safety. We hypothesised that potential long-term adverse effects of ACS may be observed among infants born during the late preterm period (LPT, 340/7–366/7 weeks of gestation), when the benefits of ACS are subtle.DesignPopulation-based, retrospective cohort.SettingOntario, Canada, between 2006 and 2011.PatientsAll live singleton infants born during the LPT period with a minimum 5-year follow-up.InterventionsExposure to ACS prior to 340/7 weeks of gestation.Main outcome measuresSuspected neurocognitive disorder, audiometry testing or visual testing.ResultsOverall, 25 668 infants were eligible for analysis, of whom 2689 (10.5%) received ACS. Infants in the ACS group had lower mean birth weight and higher rates of birth weight <10th percentile, neonatal resuscitation and neonatal intensive care unit admission. At 5 years of age, ACS exposure was associated with an increased risk of suspected neurocognitive disorder (adjusted HR (aHR) 1.12, 95% CI 1.05 to 1.20), audiometry testing (aHR 1.20, 95% CI 1.10 to 1.31) and visual testing (aHR 1.06, 95% CI 1.01 to 1.11).ConclusionIn children born during the LPT period, exposure to ACS prior to 340/7 weeks of gestation is associated with an increased utilisation of the healthcare system related to audiometry and visual testing and suspected neurocognitive disorders by 5 years of age.

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