Correlation between tumor budding, microvascular density, and β-catenin expression in colorectal carcinoma

2016 ◽  
Vol 36 (1) ◽  
pp. 108-114
Author(s):  
Samar A. El Sheikh ◽  
Amira M. Bassam ◽  
Heba A. Ibrahim
Keyword(s):  
Colorectal Carcinoma ◽  
Microvascular Density ◽  
Tumor Budding

scholarly journals Tumor budding in colorectal carcinoma assessed by cytokeratin immunostaining and budding areas: Possible involvement of c‐Met

2014 ◽  
Vol 105 (11) ◽  
pp. 1487-1495 ◽  
Author(s):  
Keisuke Satoh ◽  
Satoshi Nimura ◽  
Mikiko Aoki ◽  
Makoto Hamasaki ◽  
Kaori Koga ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Tumor Budding

scholarly journals Tumor budding and human chorionic gonadotropin-β expression correlate with unfavorable patient outcome in colorectal carcinoma

2018 ◽  
Vol 35 (7) ◽  
Author(s):  
Yuji Konishi ◽  
Futoshi Kawamata ◽  
Hiroshi Nishihara ◽  
Shigenori Homma ◽  
Yasutaka Kato ◽  
...  
Keyword(s):  
Patient Outcome ◽  
Colorectal Carcinoma ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Tumor Budding

Tumor budding in colorectal carcinoma: An institutional interobserver reliability and prognostic study of colorectal adenocarcinoma cases

2019 ◽  
Vol 43 ◽  
pp. 151420 ◽  
Author(s):  
Sean Hacking ◽  
Mallorie Angert ◽  
Cao Jin ◽  
Myriam Kline ◽  
Neha Gupta ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Colorectal Adenocarcinoma ◽  
Interobserver Reliability ◽  
Tumor Budding

Tumor budding as a new histological parameter in the metastasis of colorectal cancer

2018 ◽  
Vol 8 (2) ◽  
pp. 118-123
Author(s):  
W. Ustymowicz
Keyword(s):  
Colorectal Carcinoma ◽  
Vascular Invasion ◽  
Tumor Resection ◽  
Lymphocytic Infiltration ◽  
Tumor Budding ◽  
Cancer Tissue ◽  
Depth Of Invasion ◽  
Cytokeratin 20 ◽  
Invasion Front ◽  
Differentiated Cells

Introduction:The presence of tumor budding, i.e.,single cancer cells or a nest of poorly differentiated cells at the front of tumor invasion appears to be a new histopathological indicator of increased aggressiveness of colorectal carcinoma. Purpose: The aim of this work was a retrospective evaluation of the invasion front (tumorbudding, vascular invasion,and lymphocytic infiltration) in postoperative biopsies of patients with colorectal carcinoma and analysis of the 5-year survival. Materialsand methods:The study was based on the material received after surgical treatment of 164 patients with colon cancer. Tissue was obtained directly following tumor resection, fixed in 10% formaldehyde and embedded in paraffin blocks using a routine method by melting with paraffin at a temperature of 56º C. These samples were then routinely stained with haematoxylin and eosin and underwent a histopathological evaluation, with particular attention being paid to the invasion front of the tumor. The immunohistochemical expression of cytokeratin 20 was also evaluated using anti-human CK20 monoclonal antibody (clone Ks.20.8, Dako, Poland). Results: Tumor budding was found in 124 out of 164 patients. Statistical analysis showed a correlation between the presence of tumor budding TB and depth of invasion (pT), lymph node metastasis, distant metastasis, lymphocytic infiltration,and vascular invasion. The cumulative five-year survival correlated with the lack of tumor budding and vascular invasion, as well as a decrease in lymphocyticinfiltration.

Whole slide imaging and colorectal carcinoma: A validation study for tumor budding and stromal differentiation

2020 ◽  
Vol 216 (11) ◽  
pp. 153233
Author(s):  
Sean Hacking ◽  
Rafae Nasim ◽  
Lili Lee ◽  
Taisia Vitkovski ◽  
Rebecca Thomas ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Validation Study ◽  
Tumor Budding ◽  
Whole Slide Imaging

Automatic Detection of Tumor Budding in Colorectal Carcinoma with Deep Learning

2018 ◽  
pp. 130-138 ◽  
Author(s):  
John-Melle Bokhorst ◽  
Lucia Rijstenberg ◽  
Danny Goudkade ◽  
Iris Nagtegaal ◽  
Jeroen van der Laak ◽  
...  
Keyword(s):  
Deep Learning ◽  
Colorectal Carcinoma ◽  
Automatic Detection ◽  
Tumor Budding

scholarly journals Immunohistochemical Expression of “HCG-β” in Colorectal Carcinoma

2021 ◽  
Vol 9 (A) ◽  
pp. 789-797
Author(s):  
Amira Mohamed Bassam ◽  
Yousra Raafat ◽  
Ahmed Mahmoud Abd Al-Aziz ◽  
Rasha Ramadan Mostafa
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Colorectal Carcinoma ◽  
Tumor Invasion ◽  
Lymphovascular Invasion ◽  
Histological Grade ◽  
Signet Ring Cell ◽  
Tumor Budding ◽  
Clinicopathological Parameters ◽  
Node Metastasis

BACKGROUND: Tumor budding is associated with adverse histology and is a predictor of lymph node metastasis. Human chorionic gonadotropin-beta (hCG-β) expression in non-trophoblastic tumors has been associated with aggressive behavior. AIM: Evaluation of tumor budding and hCG-β _immunohistochemical expression in colorectal carcinoma (CRC), and correlation of their expression with various clinicopathological parameters. MATERIALS AND METHODS: Immunohistochemical staining for hCG-β _was performed on paraffin-embedded sections of 60 cases of CRC. Tumors with cytoplasmic or membranous staining of more than five epithelial cell clusters were designated hCG-β _positive; otherwise, they were designated hCG-β _negative. Tumor budding was assessed in hematoxylin and eosin stained slides and was classified as; low: 0–4 buds, intermediate: 5–9 buds and high: ≥10 buds; with exclusion of pure mucoid or signet ring cell morphology cases from analysis. RESULTS: Tumor budding was low in (58.8%) of the cases, intermediate in (15.7%), and high in (25.5%). There was a statistically significant correlation between tumor budding and tumor histological grade (p = 0.011), lymph node metastasis (N) (p = 0.009), overall pathologic stage group (p = 0.009), modified Dukes’ stage (p = 0.009), lymphovascular invasion (p = 0.000), and desmoplastic reaction (p = 0.004). Positive hCG-β _alpha expression was detected in 12 (20%) of cases. There were statistically significant correlations between hCG-β _expression and each of lymphovascular invasion (p = 0.042) and tumor budding (p = 0.000). CONCLUSION: hCG-β _is a marker of aggressiveness that may have essential role in tumor invasion. Tumor budding is crucial event in tumor invasion and metastasis. Tumor budding with hCG-β _expression is a novel prognostic parameter and may represent a potential therapeutic target.

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