Comparison of PROGRESSOR and Glaucoma Progression Analysis 2 to Detect Visual Field Progression in Treated Glaucoma Patients

2012 ◽  
Vol 1 (3) ◽  
pp. 135-139 ◽  
Author(s):  
Carlos Gustavo De Moraes ◽  
Sara R. Ghobraiel ◽  
Robert Ritch ◽  
Jeffrey M. Liebmann
Ophthalmology ◽  
2012 ◽  
Vol 119 (3) ◽  
pp. 468-473 ◽  
Author(s):  
Angelo P. Tanna ◽  
Donald L. Budenz ◽  
Jagadeesh Bandi ◽  
William J. Feuer ◽  
Robert M. Feldman ◽  
...  

2008 ◽  
Vol 93 (3) ◽  
pp. 322-328 ◽  
Author(s):  
V T Diaz-Aleman ◽  
A Anton ◽  
M G. de la Rosa ◽  
Z K Johnson ◽  
S McLeod ◽  
...  

2009 ◽  
Vol 93 (12) ◽  
pp. 1576-1579 ◽  
Author(s):  
P Casas-Llera ◽  
G Rebolleda ◽  
F J Munoz-Negrete ◽  
F Arnalich-Montiel ◽  
M Perez-Lopez ◽  
...  

2021 ◽  
pp. bjophthalmol-2020-318104
Author(s):  
Brian Stagg ◽  
Eduardo B Mariottoni ◽  
Samuel Berchuck ◽  
Alessandro Jammal ◽  
Angela R Elam ◽  
...  

Background/AimsTo investigate racial differences in the variability of longitudinal visual field testing in a ‘real-world’ clinical population, evaluate how these differences are influenced by socioeconomic status, and estimate the impact of differences in variability on the time to detect visual field progression.MethodsThis retrospective observational cohort study used data from 1103 eyes from 751 White individuals and 428 eyes from 317 black individuals. Linear regression was performed on the standard automated perimetry mean deviation values for each eye over time. The SD of the residuals from the trend lines was calculated and used as a measure of variability for each eye. The association of race with the SD of the residuals was evaluated using a multivariable generalised estimating equation model with an interaction between race and zip code income. Computer simulations were used to estimate the time to detect visual field progression in the two racial groups.ResultsBlack patients had larger visual field variability over time compared with white patients, even when adjusting for zip code level socioeconomic variables (SD of residuals for Black patients=1.53 dB (95% CI 1.43 to 1.64); for white patients=1.26 dB (95% CI 1.14 to 1.22); mean difference: 0.28 (95% CI 0.15 to 0.41); p<0.001). The difference in visual field variability between black and white patients was greater at lower levels of income and led to a delay in detection of glaucoma progression.ConclusionBlack patients had larger visual field variability compared with white patients. This relationship was strongly influenced by socioeconomic status and may partially explain racial disparities in glaucoma outcomes.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Guihua Xu ◽  
Zilin Chen

AbstractTo evaluate the role of corneal hysteresis (CH) as a risk factor for progressive ONH surface depression and RNFL thinning measured by confocal scanning laser ophthalmoscopy (CSLO) and spectral-domain optical coherence tomography (SD-OCT), respectively in glaucoma patients. Prospective study. A total of 146 eyes of 90 patients with glaucoma were recruited consecutively. The CH measurements were acquired at baseline and 4-months interval using the Ocular Response Analyzer (Reichert Instruments, Depew, NY). Eyes were imaged by CSLO (Heidelberg Retinal Tomograph [HRT]; Heidelberg Engineering, GmbH, Dossenheim, Germany) and SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec AG, Dublin, CA) at approximately 4-month intervals for measurement of ONH surface topography and RNFL thickness, respectively. Significant ONH surface depression and RNFL thinning were defined with reference to Topographic Change Analysis (TCA) with HRT and Guided Progression Analysis (GPA) with Cirrus HD-OCT, respectively. Multivariate cox proportional hazards models were used to investigate whether CH is a risk factor for ONH surface depression and RNFL progression after adjusting potential confounding factors. All patients with glaucoma were followed for an average of 6.76 years (range, 4.56–7.61 years). Sixty-five glaucomatous eyes (44.5%) of 49 patients showed ONH surface depression, 55 eyes (37.7%) of 43 patients had progressive RNFL thinning and 20 eyes (13.7%) of 17 patients had visual field progression. In the cox proportional hazards model, after adjusting baseline diastolic IOP, CCT, age, baseline disc area and baseline MD, baseline CH was significantly associated with ONH surface depression and visual field progression (HR = 0.71, P = 0.014 and HR = 0.54, P = 0.018, respectively), but not with RNFL thinning (HR = 1.03, P = 0.836). For each 1-mmHg decrease in baseline CH, the hazards for ONH surface depression increase by 29%, and the hazards for visual field progression increase by 46%. The CH measurements were significantly associated with risk of glaucoma progression. Eyes with a lower CH were significantly associated with an increased risk of ONH surface depression and visual field progression in glaucoma patients.


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