Predictors of Treatment Response in Pediatric Obsessive-Compulsive Disorder

2008 ◽  
Vol 47 (8) ◽  
pp. 868-878 ◽  
Author(s):  
Golda S. Ginsburg ◽  
Julie Newman Kingery ◽  
Kelly L. Drake ◽  
Marco A. Grados
Keyword(s):  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Treatment response in obsessive compulsive disorder

1991 ◽  
Vol 1 (3) ◽  
pp. 277-279
Author(s):  
N.A Fineberg ◽  
T Bullock ◽  
D.B Montgomery ◽  
S.A Montgomery
Keyword(s):  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Predicting Treatment Response in Obsessive-Compulsive Disorder

2002 ◽  
Vol 14 (3) ◽  
pp. 249-253 ◽  
Author(s):  
Robin A. Hurley ◽  
Sanjaya Saxena ◽  
Scott L. Rauch ◽  
Rudolf Hoehn-Saric ◽  
Katherine H. Taber
Keyword(s):  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Does GRIN2B gene influence obsessive-compulsive disorder risk, symptom dimensions and treatment response?

2018 ◽  
Vol 31 ◽  
pp. 150-151 ◽  
Author(s):  
Biju Viswanath ◽  
Reshma Jabeen Taj MJ ◽  
Ravi Kumar Nadella ◽  
Tulika Shukla ◽  
Madhuri H. Nanjundaswamy ◽  
...  
Keyword(s):  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Symptom Dimensions ◽  
Compulsive Disorder ◽  
Risk Symptom ◽  
Disorder Risk

Clinical features associated with treatment response in obsessive-compulsive disorder

2006 ◽  
Vol 47 (4) ◽  
pp. 276-281 ◽  
Author(s):  
Roseli G. Shavitt ◽  
Cristina Belotto ◽  
Mariana Curi ◽  
Ana G. Hounie ◽  
Maria C. Rosário-Campos ◽  
...  
Keyword(s):  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Clinical Features ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Aripiprazole augmentation of incomplete treatment response in an adolescent male with obsessive-compulsive disorder

2008 ◽  
Vol 25 (2) ◽  
pp. 172-174 ◽  
Author(s):  
Eric A. Storch ◽  
Heather Lehmkuhl ◽  
Gary R. Geffken ◽  
Alexis Touchton ◽  
Tanya K. Murphy
Keyword(s):  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Adolescent Male ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Incomplete Treatment

scholarly journals Defining data-driven subgroups of obsessive–compulsive disorder with different treatment responses based on resting-state functional connectivity

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Seoyeon Kwak ◽  
Minah Kim ◽  
Taekwan Kim ◽  
Yoobin Kwak ◽  
Sanghoon Oh ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Resting State ◽  
Predictive Biomarkers ◽  
Support Vector ◽  
Resting State Functional Connectivity ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Treatment Responses

Abstract Characterization of obsessive–compulsive disorder (OCD), like other psychiatric disorders, suffers from heterogeneities in its symptoms and therapeutic responses, and identification of more homogeneous subgroups may help to resolve the heterogeneity. We aimed to identify the OCD subgroups based on resting-state functional connectivity (rsFC) and to explore their differences in treatment responses via a multivariate approach. From the resting-state functional MRI data of 107 medication-free OCD patients and 110 healthy controls (HCs), we selected rsFC features, which discriminated OCD patients from HCs via support vector machine (SVM) analyses. With the selected brain features, we subdivided OCD patients into subgroups using hierarchical clustering analyses. We identified 35 rsFC features that achieved a high sensitivity (82.74%) and specificity (76.29%) in SVM analyses. The OCD patients were subdivided into two subgroups, which did not show significant differences in their demographic and clinical backgrounds. However, one of the OCD subgroups demonstrated more impaired rsFC that was involved either within the default mode network (DMN) or between DMN brain regions and other network regions. This subgroup also showed both lower improvements in symptom severity in the 16-week follow-up visit and lower responder percentage than the other subgroup. Our results highlight that not only abnormalities within the DMN but also aberrant rsFC between the DMN and other networks may contribute to the treatment response and support the importance of these neurobiological alterations in OCD patients. We suggest that abnormalities in these connectivity may play predictive biomarkers of treatment response, and aid to build more optimal treatment strategies.

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