Postnatal exposure to PM2.5 and weight trajectories in early childhood

OBJECTIVES/GOALS: It is hypothesized that the global secular trend toward earlier puberty onset, with implications for many future health outcomes, is related to the obesity epidemic. This study aims to examine prospective associations between weight during specific developmental windows and timing of puberty onset. METHODS/STUDY POPULATION: This study includes 1,296 mother-infant dyads from the Boston Birth Cohort, a predominantly minority (>80% black/Hispanic), low-income, and urban prospective birth cohort recruited and followed between 1998 and 2019. Age at peak height velocity (APHV), a well-defined and standardized proxy for puberty onset, is derived by fitting height measurements recorded during clinical visits using a mixed effects growth curve model. Multiple linear regression is performed to examine the relationships between early childhood (ages 2-5y) and prepubertal (ages 6-9y) overweight and obesity, weight trajectories between these two periods, and APHV, while controlling for known contributors to early puberty. RESULTS/ANTICIPATED RESULTS: Compared to counterparts with normal BMIs, kids who were obese during ages 2-5y (boys: −0.21y, CI[−0.39, −0.04]; girls: −0.22y, CI[−0.39, −0.05]) or ages 6-9y (boys: −0.27y, CI[−0.43, −0.11]; girls: −0.37y, CI[−0.52, −0.23]) had an earlier APHV. Being overweight during ages 6-9y was also associated an earlier APHV (boys: −0.26y, CI[−0.46, −0.07]; girls: −0.26y, CI[−0.42, −0.10]). Looking at weight trajectories, kids who were persistently overweight or obese from ages 2-5y to ages 6-9y had an earlier APHV (boys: −0.28y, CI[−0.45, −0.12]; girls: −0.31y, CI[−0.46, −0.16]), as did girls with normal BMIs during ages 2-5y and who were overweight or obese during ages 6-9y (−0.45y CI[−0.64, −0.26]). DISCUSSION/SIGNIFICANCE OF IMPACT: The temporal and dose-response relationships seen in this historically understudied population suggests that childhood obesity is etiologically important in the development, and even programming, of early puberty. This has implications for prediction, prevention, and mitigation of health disparities.

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Associations Between Prenatal And Postnatal Exposure To Piperonyl Butoxide And Permethrin Pesticides On Cough In Early Childhood

10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1757 ◽

2012 ◽

Author(s):

Bian Liu ◽

Kyung H. Jung ◽

Megan K. Horton ◽

David E. Camann ◽

Xinhua Liu ◽

...

Keyword(s):

Early Childhood ◽

Piperonyl Butoxide ◽

Postnatal Exposure

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Effects of Pre- and Postnatal Exposure to Parental Smoking on Early Childhood Respiratory Health

Epidemiology ◽

10.1097/01.ede.0000288437.24029.bd ◽

2007 ◽

Vol 18 (Suppl) ◽

pp. S108-S109

Author(s):

S E Håberg

Keyword(s):

Early Childhood ◽

Respiratory Health ◽

Parental Smoking ◽

Postnatal Exposure

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Early individual and family predictors of weight trajectories from early childhood to adolescence: results from the Millennium Cohort Study

10.1101/2020.02.26.20027409 ◽

2020 ◽

Cited By ~ 1

Author(s):

Constança Soares dos Santos ◽

João Picoito ◽

Carla Nunes ◽

Isabel Loureiro

Keyword(s):

Early Childhood ◽

Cohort Study ◽

Weight Gain ◽

Maternal Education ◽

Self Regulation ◽

Growth Mixture Modeling ◽

Millennium Cohort Study ◽

Early Weight Gain ◽

Bmi Trajectories ◽

Weight Trajectories

AbstractBackgroundEarly infancy and childhood are critical periods in the establishment of lifelong weight trajectories. Parents and early family environment have a strong effect on children’s health behaviors that track into adolescence, influencing lifelong risk of obesity.ObjectiveWe aimed to identify developmental trajectories of body mass index (BMI) from early childhood to adolescence and to assess their early individual and family predictors.MethodsThis was a secondary analysis of the Millennium Cohort Study and included 17,166 children. Weight trajectories were estimated using growth mixture modeling based on age- and gender-specific BMI Z-scores, followed by a bias-adjusted regression analysis.ResultsWe found four BMI trajectories: Weight Loss (69%), Early Weight Gain (24%), Early Obesity (3.7%), and Late Weight Gain (3.3%). Weight trajectories were mainly settled by early adolescence. Lack of sleep and eating routines, low emotional self-regulation, child-parent conflict, and low child-parent closeness in early childhood were significantly associated with unhealthy weight trajectories, alongside poverty, low maternal education, maternal obesity, and prematurity.ConclusionsUnhealthy BMI trajectories were defined in early and middle-childhood, and disproportionally affected children from disadvantaged families. This study further points out that household routines, self-regulation, and child-parent relationships are possible areas for family-based obesity prevention interventions.

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