High predictive value of CYP2B6 SNPs for steady-state plasma efavirenz levels in South African HIV/AIDS patients

Background: The lungs are one of the primary target organs for HIV disease and a major source of morbidity and mortality, among others, caused by Pneumocystis carinii pneumonia (PCP) or recurrent bacterial pneumonia. In developing countries, the incidence of PCP infection has soared, with high mortality rates ranging from 20% to 80%. The increase in serum LDH plays an important role in determining the severity of the disease. This study aims to determine the role of LDH examination as a diagnostic tool for PCP and Arterial Blood Gases (ABG) in HIV and AIDS patients. Method: This research is an analytical study using an observational diagnostic test design, conducted from November 2020-January 2021 at the HIV Treatment Room at H. Adam Malik Hospital, Medan with 158 subjects. We calculate the value of sensitivity, specificity, positive predictive value, and negative predictive value. Results: 75.3% of the total sample was male, with the highest age group being 30-39 years old (46.2%) 126 samples (79.7%) had CD4 levels 200 cells/mm3, 98 samples (62%) had LDH levels > 500 U/L. In this study, 113 samples (71.5%) fell into the ABG criteria [PaO2] <70 mmHg). LDH has superior sensitivity and specificity value compared to ABG examination. In this case PaO2 or A-A DO2 in diagnosing PCP in HIV-AIDS patients. Conclusion: LDH examination combined with clinical and radiological examinations has good sensitivity and specificity in the diagnosis of PCP. Keywords: HIV, AIDS, Lactate dehydrogenase, PCP.

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Oral candidiasis and oral yeast carriage among institutionalised South African paediatric HIV/AIDS patients

Mycopathologia ◽

10.1007/s11046-006-0087-9 ◽

2007 ◽

Vol 163 (2) ◽

pp. 67-73 ◽

Cited By ~ 25

Author(s):

Elaine Blignaut

Keyword(s):

South African ◽

Oral Candidiasis ◽

Aids Patients ◽

Paediatric Hiv ◽

Hiv Aids

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Are physiotherapy graduates adequately prepared to to manage hiv/aids patients

South African Journal of Physiotherapy ◽

10.4102/sajp.v60i2.184 ◽

2004 ◽

Vol 60 (2) ◽

Cited By ~ 3

Author(s):

T. Puckree ◽

B. J. Chetty ◽

V. Govender ◽

S. Ramparsad ◽

J. Lin

Keyword(s):

South African ◽

Clinical Skills ◽

Aids Patients ◽

Human Immuno Deficiency Virus ◽

Knowledge And Attitudes ◽

Transmission Modes ◽

South African Universities ◽

Acquired Immunodeficiency ◽

Immunodeficiency Syndrome ◽

Hiv Aids

Physiotherapy learners treat patients with Human Immuno-deficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS). There is no available published research on physiotherapy learners' opinions about how the South Afican physiotherapy undergraduate program is helping them cope with HIV/AIDS patients. This study determines whether the physiotherapy degree offered at South African Universities, adequately prepares learners to cope with HIV/AIDS patients. Differences in knowledge and attitudes of physiotherapy learners regarding HIV/AIDS, amongst universities is also explored. Two hundred and two senior physiotherapy learners from eight South African universities returned their questionnaires and 55% of these were viable for analysis. A large portion (79%) of learners indicated that the physiotherapy undergraduate degree did not adequately prepare them to cope with HIV/AIDS patients. Learners' knowledge and attitudes regarding HIV/AIDS differed significantly (41% to 73%) amongst universities. Formal lectures on HIV/AIDS significantly affected knowledge (0% -100%) but not attitude towards patients. The role of the physiotherapist, precautions, transmission modes, syndrome stages, counseling and clinical skills were considered critical in the management of HIV/AIDS patients.

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