scholarly journals The Role of Lactate Dehydrogenase (LDH) Compared to Arterial Blood Gases (ABG) in Diagnosing Pneumocystis Carinii Pneumonia (PCP) in HIV/AIDS Patients on Routine Antiretroviral Therapy

2021 ◽  
Vol 8 (10) ◽  
pp. 1-7
Author(s):  
Aulia Rahman ◽  
Tambar Kembaren ◽  
Endang Sembiring
Keyword(s):  
Lactate Dehydrogenase ◽  
Pneumocystis Carinii Pneumonia ◽  
Predictive Value ◽  
Pneumocystis Carinii ◽  
Blood Gases ◽  
Arterial Blood Gases ◽  
Aids Patients ◽  
Arterial Blood ◽  
Hiv Aids

Background: The lungs are one of the primary target organs for HIV disease and a major source of morbidity and mortality, among others, caused by Pneumocystis carinii pneumonia (PCP) or recurrent bacterial pneumonia. In developing countries, the incidence of PCP infection has soared, with high mortality rates ranging from 20% to 80%. The increase in serum LDH plays an important role in determining the severity of the disease. This study aims to determine the role of LDH examination as a diagnostic tool for PCP and Arterial Blood Gases (ABG) in HIV and AIDS patients. Method: This research is an analytical study using an observational diagnostic test design, conducted from November 2020-January 2021 at the HIV Treatment Room at H. Adam Malik Hospital, Medan with 158 subjects. We calculate the value of sensitivity, specificity, positive predictive value, and negative predictive value. Results: 75.3% of the total sample was male, with the highest age group being 30-39 years old (46.2%) 126 samples (79.7%) had CD4 levels 200 cells/mm3, 98 samples (62%) had LDH levels > 500 U/L. In this study, 113 samples (71.5%) fell into the ABG criteria [PaO2] <70 mmHg). LDH has superior sensitivity and specificity value compared to ABG examination. In this case PaO2 or A-A DO2 in diagnosing PCP in HIV-AIDS patients. Conclusion: LDH examination combined with clinical and radiological examinations has good sensitivity and specificity in the diagnosis of PCP. Keywords: HIV, AIDS, Lactate dehydrogenase, PCP.

THE ROLE OF SEQUENTIAL GALLIUM SCANNING IN AIDS PATIENTS DURING TREATMENT FOR PNEUMOCYSTIS CARINII PNEUMONIA

1987 ◽  
Vol 15 (4) ◽  
pp. 411
Author(s):  
Matthew Brenner ◽  
Frederick P. Ognibene ◽  
Jorge A. Carrasquillo ◽  
Emest E. Lack ◽  
Anthony F. Suffredini ◽  
...  
Keyword(s):  
Pneumocystis Carinii Pneumonia ◽  
Pneumocystis Carinii ◽  
Aids Patients ◽  
Gallium Scanning

What is the role of T-lymphocytes with gamma/delta receptors in Pneumocystis carinii pneumonia in AIDS patients?

AIDS ◽  
1994 ◽  
Vol 8 (3) ◽  
pp. 395 ◽  
Author(s):  
O. Perrella ◽  
A. Perrella ◽  
E. Soscia ◽  
A. Marinelli ◽  
V. Mininni ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Pneumocystis Carinii Pneumonia ◽  
Pneumocystis Carinii ◽  
Gamma Delta ◽  
Aids Patients ◽  
Delta Receptors

Brain ECF pH and central chemical control of ventilation during anoxia in turtles

1987 ◽  
Vol 252 (5) ◽  
pp. R848-R852 ◽  
Author(s):  
D. G. Davies ◽  
J. A. Sexton
Keyword(s):  
Ventilatory Response ◽  
Minute Ventilation ◽  
Control Period ◽  
Extracellular Fluid ◽  
Blood Gases ◽  
Breathing Frequency ◽  
Arterial Blood Gases ◽  
Brain Extracellular Fluid ◽  
Arterial Blood

The role of changes in brain extracellular fluid [H+] in the control of breathing during anoxia was studied in unanesthetized turtles, Chrysemys scripta. Ventilation, [minute ventilation (VE), tidal volume (VT), and breathing frequency (f)], cerebral extracellular fluid (ECF) pH, and arterial blood gases were measured at 25 degrees C during a 30-min control period (room air), 30 min of anoxia (100% N2 breathing), and 60 min of recovery (room air). ECF pH was measured in the cerebral cortex with a glass microelectrode (1-2 micron tip diam). Large changes in ventilation, ECF [H+], and arterial blood gases were observed. The predominant ventilatory response was an increase in f with a slight increase in VT. A correlation was observed between ECF [H+] and f, which suggested that central chemoreceptor stimulation was involved in the ventilatory response.

scholarly journals Role of cerebral blood flow in extreme breath holding

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Anthony R. Bain ◽  
Philip N. Ainslie ◽  
Ryan L. Hoiland ◽  
Chris K. Willie ◽  
David B. MacLeod ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Oral Administration ◽  
Blood Gases ◽  
Breath Holding ◽  
Breath Hold ◽  
Cyclooxygenase Inhibitor ◽  
Arterial Blood Gases ◽  
Arterial Blood

AbstractThe role of cerebral blood flow (CBF) on a maximal breath-hold (BH) in ultra-elite divers was examined. Divers (n = 7) performed one control BH, and one BH following oral administration of the non-selective cyclooxygenase inhibitor indomethacin (1.2 mg/kg). Arterial blood gases and CBF were measured prior to (baseline), and at BH termination. Compared to control, indomethacin reduced baseline CBF and cerebral delivery of oxygen (CDO

Respiratory acidosis in carbonic anhydrase II-deficient mice

1998 ◽  
Vol 274 (2) ◽  
pp. L301-L304 ◽  
Author(s):  
Yeong-Hau H. Lien ◽  
Li-Wen Lai
Keyword(s):  
Metabolic Acidosis ◽  
Carbonic Anhydrase ◽  
Respiratory Acidosis ◽  
Blood Gases ◽  
Arterial Blood Gases ◽  
Arterial Blood ◽  
Blood Ph ◽  
Type Ii Pneumocytes ◽  
Deficient Mice

To investigate the role of carbonic anhydrase (CA) II on pulmonary CO2 exchange, we analyzed arterial blood gases from CA II-deficient and normal control mice. CA II-deficient mice had a low arterial blood pH (7.18 ± 0.06) and[Formula: see text] concentration ([[Formula: see text]]; 17.5 ± 1.9 meq/l) and a high [Formula: see text](47.4 ± 5.3 mmHg), consistent with mixed respiratory and metabolic acidosis. To eliminate the influence of metabolic acidosis on arterial blood gases, NaHCO3 (4 mmol/kg body weight) was given intraperitoneally, and arterial blood gases were analyzed 4 h later. Normal mice had a small increase in pH and were able to maintain [Formula: see text] and [[Formula: see text]]. The metabolic acidosis in CA II-deficient mice was corrected ([[Formula: see text]], 22.9 ± 2.4 meq/l), and respiratory acidosis became more profound ([Formula: see text], 50.4 ± 2.4 mmHg). These results indicate that CA II-deficient mice have a partial respiratory compensation for metabolic acidosis. We conclude that CA II-deficient mice have a mixed respiratory and metabolic acidosis. It is most likely that CO2 retention in these animals is due to CA II deficiency in both red blood cells and type II pneumocytes.

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