Comparative Postural Control in COPD Patients and Healthy Individuals During Dynamic and Static Activities

2017 ◽  
Vol 37 (2) ◽  
pp. 139-145 ◽  
Author(s):  
Elias F. Porto ◽  
Cristiane O. Pradella ◽  
Carolina M. Rocco ◽  
Mario Chueiro ◽  
Rafaella Q. Maia ◽  
...  
Keyword(s):  
Postural Control ◽  
Healthy Individuals ◽  
Copd Patients

scholarly journals Impact of Matrix Metalloproteinase 9 on COPD Development in Polish Patients: Genetic Polymorphism, Protein Level, and Their Relationship with Lung Function

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Iwona Gilowska ◽  
Łukasz Kasper ◽  
Katarzyna Bogacz ◽  
Jan Szczegielniak ◽  
Teresa Szymasek ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Lung Function ◽  
Copy Number Variants ◽  
Serum Levels ◽  
Chronic Obstructive ◽  
Healthy Individuals ◽  
Tissue Destruction ◽  
Genotype Frequencies ◽  
Gene Copies ◽  
Copd Patients

Chronic obstructive pulmonary disease (COPD) is characterized by a decline of lung function and symptoms such as chronic bronchitis and emphysema leading from lung tissue destruction. Increased activity of matrix metalloproteinases (MMPs) and an imbalance between MMPs and their tissue inhibitors (TIMPs) are considered as factors influencing the pathogenesis of COPD. We investigated the role of genetic polymorphism and expression level of MMP-9 and concentration of its complexes with TIMPs in the development of COPD among Polish patients. We analyzed SNP in the promoter region of MMP-9 gene (rs3918242) using PCR-RFLP method among 335 COPD patients and 309 healthy individuals. Additionally, 60 COPD patients and 61 controls were tested for copy number variants (CNV) of MMP-9 (by quantitative real-time PCR) and serum levels of MMP-9 and its complexes with TIMP1 and TIMP2 (using ELISA). All subjects were analyzed for lung function using spirometry (FEV1% and FEV1/FVC parameters). We observed that allele and genotype frequencies of the SNP rs3918242, as well as the number of gene copies, were similar in COPD patient and controls groups. Serum levels of MMP-9 and MMP-9/TIMP1 complex were significantly higher in COPD patients in comparison to controls groups, although independently of analyzed gene polymorphisms. Additionally, the significant inverse relationships between parameters of lung function (FEV1% and FEV1/FVC) and proteins level were found in ridge regression models, especially we found that FEV1% decreased when MMP-9 level increased in controls and patients with COPD group. In conclusion, we found that COPD patients were predisposed to produce more MMP-9 and MMP-9/TIMP1 complex than healthy individuals. This phenomenon is probably associated with the disease-related lung environment but not with genetic features of the MMP-9.

scholarly journals The effect of induced sputum and bronchoalveolar lavage fluid from patients with chronic obstructive pulmonary disease on neutrophil migration in vitro

Medicina ◽  
2010 ◽  
Vol 46 (5) ◽  
pp. 315 ◽  
Author(s):  
Agnė Babušytė ◽  
Jolanta Jeroch ◽  
Rimantas Stakauskas ◽  
Kristina Stravinskaitė ◽  
Kęstutis Malakauskas ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Neutrophil Migration ◽  
Lavage Fluid ◽  
Interleukin 8 ◽  
Induced Sputum ◽  
Chronic Obstructive ◽  
Healthy Individuals ◽  
Copd Patients

Objective. The aim of study was to investigate a chemotactic effect of induced sputum and bronchoalveolar lavage fluid on blood neutrophils in patients with chronic obstructive pulmonary disease (COPD) and healthy individuals. Material and methods. Forty-three smokers with COPD, 19 ex-smokers with COPD, 13 healthy smokers, and 17 healthy nonsmokers were recruited to the study. Neutrophils were isolated from peripheral blood of study individuals. For the same experimental conditions, pooled induced sputum and bronchoalveolar lavage fluid of 20 COPD patients were used. Neutrophil chemotaxis in vitro was performed in cell-transmigration chamber. Substances tested for chemoattraction (interleukin-8, induced sputum, bronchoalveolar lavage fluid directly or in addition to interleukin-8) were added to lower wells. Upper wells were filled with 2.5×106/mL of neutrophil culture and incubated for 2 hours. Migration was analyzed by flow cytometry. Results. Interleukin-8 (10–100 ng/mL) induced a dose-dependant neutrophil migration in all the groups. Only 100 ng/L of interleukin-8 induced more intensive chemotaxis of neutrophils from COPD smokers as compared to ex-smokers (P<0.05). Such difference between healthy individuals was obtained using 30 ng/mL of interleukin-8 (P<0.05). Induced sputum/interleukin-8 (10–100 ng/mL), as well as induced sputum directly, induced neutrophil migration (P<0.05). Chemotaxis of neutrophils isolated from COPD patients and healthy nonsmokers did not depend on additional interleukin-8 concentration. Bronchoalveolar lavage fluid/interleukin-8 (30–100 ng/mL) induced more intensive migration of neutrophils from COPD patients than bronchoalveolar lavage fluid (P<0.05) alone. Conclusions. Migration of neutrophils isolated from patients with COPD was more intensive compared to healthy individuals. Induced sputum and bronchoalveolar lavage fluid directly and with addition of interleukin-8 stimulated chemotaxis, and it was higher in neutrophils from COPD patients. Migration of neutrophils did not depend on smoking status.

scholarly journals MECHANISMS OF COUNTERACTING FLAP-VALVE BRONCHIAL OBSTRUCTION IN CASE OF OBSTRUCTIVE PULMONARY EMPHYSEMA

2015 ◽  
Vol 14 (4) ◽  
pp. 75-81 ◽  
Author(s):  
K. F. Tetenev ◽  
F. F. Tetenev ◽  
T. S. Ageyeva ◽  
T. N. Bodrova ◽  
A. I. Karzilov ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Pulmonary Emphysema ◽  
Air Flow ◽  
Bronchial Obstruction ◽  
Forced Expiration ◽  
Healthy Individuals ◽  
Copd Patients ◽  
Isolated Lungs ◽  
Expiratory Air ◽  
Flap Valve

The research goal was to formulate and substantiate the hypothesis explaining support for an expiratory air flow in case of pulmonary emphysema. The research method consisted in comparing the mechanical properties of lungs in practically healthy individuals (37 individuals, mean age – (30.4 ± 1.7) y.o.) and COPD patients with pronounced lung emphysema (30 patients, mean age – (52.1 ± 2.3) y.o.) as well as those of isolated normal lungs (n = 14) and isolated lungs of patients who died of COPD (n = 5). Pulmo-nary mechanics was studied via the simultaneous measurement of transpulmonary pressure and lung ven-tilation volume. General lung hysteresis and elastic lung hysteresis were calculated. The mechanical properties of isolated lungs were studied using passive ventilation under the Donders bell. The air flow was interrupted in order to measure alveolar pressure and develop an elastic lung hysteresis curve. Pres-sure in the Donders bell was changed by means of a special pump in automatic and manual modes. The research has not revealed any fundamental differences between the mechanical properties of the normal and emphysematous lungs. A minimum increase in the pressure inside the Donders bell over atmospheric pressure used to stop air ejection in both normal and the emphysematous lungs as the result of flap-valve bronchial obstruction. In living beings, air is ejected from lungs with an increase in pressure under the conditions of forced expiration. Pressure increases up to (38.6 ± 2.71) cm H2O in healthy individuals and up to (20.5 ± 1.86) cm H2O in COPD patients. Probably, an expiratory air flow is supported by active expiratory bronchial dilatation that counteracts flap-valve bronchial obstruction. The hypothesis is based on the confirmed ability of the lungs to perform inspiratory actions (in addition to the action of respiratory muscles) and the theory of mechanical lung activity.

Bipedal postural control in severe COPD patients with bronchitic and emphysematic phenotype

2015 ◽  
Author(s):  
Katerina Neumannova ◽  
Vladimir Koblizek ◽  
Nicolas Vuillerme ◽  
Zdenek Svoboda ◽  
Vratislav Sedlak ◽  
...  
Keyword(s):  
Postural Control ◽  
Copd Patients ◽  
Severe Copd

Postural control in COPD patients travelling from 760 m to 3200 m; randomized trial evaluating effects of dexamethasone

2016 ◽  
Author(s):  
Lara Muralt ◽  
Michael Furian ◽  
Mona Lichtblau ◽  
Sayaka S. Aeschbacher ◽  
Maya Bisang ◽  
...  
Keyword(s):  
Postural Control ◽  
Randomized Trial ◽  
Copd Patients

scholarly journals The influence of fear of falling on orthostatic postural control: a systematic review

2015 ◽  
Vol 7 (3) ◽  
Author(s):  
Nélio Silva De Souza ◽  
Ana Carolina Gomes Martins ◽  
Dângelo J.A. Alexandre ◽  
Marco Orsini ◽  
Victor Hugo Do Vale Bastos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Postural Control ◽  
Control Strategy ◽  
Environmental Changes ◽  
Fear Of Falling ◽  
Motor Behavior ◽  
Center Of Pressure ◽  
Healthy Individuals ◽  
Physiological Mechanisms ◽  
Postural Control Strategy

Posture is a complex sensory-motor behavior that can be influenced by the fear of falling (FoF) during environmental changes. The aim of this paper is to investigate the influence of FoF on orthostatic postural control in healthy individuals by a systematic review. Thirteen articles were selected. Some other articles (31 references) were used to contextualize and discuss the topic. Studies in the environment made changes on the environment, in which participants were positioned in high hydraulic platforms at different heights, showed a decrease in the center of pressure in the anteroposterior oscillation where the platform was higher. This change in postural control strategy and the FoF are correlated. It can modulate the activity of the muscle spindle (H-reflex) and probably induce postural freezing phenomenon (anticipated postural anxiety). We can conclude that further studies are needed to understand the physiological mechanisms involved in FoF and its relation to changes in postural control strategy.

scholarly journals The prevalence of PI*S and PI*Z SERPINA1 alleles in healthy individuals and COPD patients in Saudi Arabia

Medicine ◽  
2017 ◽  
Vol 96 (42) ◽  
pp. e8320 ◽  
Author(s):  
Noura Al-Jameil ◽  
Amina A. Hassan ◽  
Rana Hassanato ◽  
Sree R. Isac ◽  
Maram Al Otaiby ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Healthy Individuals ◽  
Copd Patients
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