A Conversation on a Healing Model With Jill Rathburn, BSN, RN, BCC, CPRC

2022 ◽  
Vol 36 (1) ◽  
pp. 52-55
Author(s):  
Gloria F. Donnelly
Keyword(s):  
2014 ◽  
Vol 320 (1) ◽  
pp. 79-91 ◽  
Author(s):  
Nina Tandon ◽  
Elisa Cimetta ◽  
Aranzazu Villasante ◽  
Nicolette Kupferstein ◽  
Michael D. Southall ◽  
...  

2011 ◽  
Vol 15 (3) ◽  
pp. 460-469 ◽  
Author(s):  
Wook-Jin Seong ◽  
Shahrzad Grami ◽  
Soo Cheol Jeong ◽  
Heather J. Conrad ◽  
James S. Hodges

2008 ◽  
Vol 25 (3) ◽  
pp. 209-226 ◽  
Author(s):  
Juyoung Park ◽  
George Carlson ◽  
Stanley Weinstein ◽  
Bethany Lee
Keyword(s):  

2015 ◽  
Vol 4 (5) ◽  
pp. 312-320 ◽  
Author(s):  
A.B. Mohd Hilmi ◽  
Asma Hassan ◽  
Ahmad Sukari Halim

Genes ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 47
Author(s):  
Carlos León ◽  
Francisco García-García ◽  
Sara Llames ◽  
Eva García-Pérez ◽  
Marta Carretero ◽  
...  

Defective healing leading to cutaneous ulcer formation is one of the most feared complications of diabetes due to its consequences on patients’ quality of life and on the healthcare system. A more in-depth analysis of the underlying molecular pathophysiology is required to develop effective healing-promoting therapies for those patients. Major architectural and functional differences with human epidermis limit extrapolation of results coming from rodents and other small mammal-healing models. Therefore, the search for reliable humanized models has become mandatory. Previously, we developed a diabetes-induced delayed humanized wound healing model that faithfully recapitulated the major histological features of such skin repair-deficient condition. Herein, we present the results of a transcriptomic and functional enrichment analysis followed by a mechanistic analysis performed in such humanized wound healing model. The deregulation of genes implicated in functions such as angiogenesis, apoptosis, and inflammatory signaling processes were evidenced, confirming published data in diabetic patients that in fact might also underlie some of the histological features previously reported in the delayed skin-humanized healing model. Altogether, these molecular findings support the utility of such preclinical model as a valuable tool to gain insight into the molecular basis of the delayed diabetic healing with potential impact in the translational medicine field.


BIO-PROTOCOL ◽  
2019 ◽  
Vol 9 (13) ◽  
Author(s):  
Ligia Estevão ◽  
Puebla Cassini-Vieira ◽  
Ana Greice Leite ◽  
Apolônia Bulhões ◽  
Lucíola da Barcelos ◽  
...  

2017 ◽  
Vol 139 (2) ◽  
pp. 343-352 ◽  
Author(s):  
Clement D. Marshall ◽  
Michael S. Hu ◽  
Tripp Leavitt ◽  
Leandra A. Barnes ◽  
Alexander T. M. Cheung ◽  
...  

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