scholarly journals Spontaneous closure of degenerative lamellar macular hole with epiretinal membrane proliferation

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Rony C. Preti ◽  
Leandro C. Zacharias ◽  
Leonardo P. Cunha ◽  
Mario L. R. Monteiro ◽  
David Sarraf
Keyword(s):  
Macular Hole ◽  
Epiretinal Membrane ◽  
Vision Loss ◽  
Surgical Intervention ◽  
Spontaneous Closure ◽  
Müller Cell ◽  
Lamellar Macular Hole ◽  
Cystic Fluid ◽  
Muller Cell ◽  
Sd Oct

Abstract Background To describe the spontaneous closure of a degenerative lamellar macular hole with epiretinal proliferation (LHEP) as documented with tracked spectral domain optical coherence tomography (SD-OCT). Case presentation A 54-years-old diabetic female patient presented with progressive vision loss in the left eye. SD-OCT illustrated LHEP associated with cystic fluid in the outer nuclear layer. Sequentially tracked SD-OCT showed progressive closure of the degenerative lamellar macular hole and resolution of the CME over almost 4 years, in the absence of any surgical intervention. Discussion/conclusion LHEP may represent a specialized form of degenerative epiretinal membrane associated with Muller cell activation. Spontaneous degenerative LMH closure may rarely occur with these lesion types, in the absence of surgical intervention, possibly due to Muller cell proliferation preceded by PVD.

scholarly journals Development of Stage 4 Macular Hole after Spontaneous Closure in a Patient with Stage 2 Macular Hole and a Lamellar Macular Hole-Associated Epiretinal Proliferation

2021 ◽  
pp. 481-484
Author(s):  
Masahisa Watanabe ◽  
Harumasa Yokota ◽  
Hiroshi Aso ◽  
Hirotsugu Hanazaki ◽  
Junya Hanaguri ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Macular Hole ◽  
Spontaneous Closure ◽  
Surgical Removal ◽  
Lamellar Macular Hole ◽  
Full Thickness ◽  
Stage 4 ◽  
Full Thickness Macular Hole ◽  
The Right ◽  
Hole Closure

Herein, we report the longitudinal observation of a case with reopening of the macular hole associated with a lamellar macular hole-associated epiretinal proliferation (LHEP) followed by spontaneous closure in patients with stage 2 idiopathic macular hole. A 64-year-old woman was referred for the decreased visual acuity (VA) and acute anorthopia in the right eye. Funduscopy and optical coherence tomography (OCT) showed stage 2 full-thickness macular hole without posterior vitreous detachment (PVD) and operculum formation. Her best-corrected visual acuity (BCVA) was 20/32. One month later, the diameter of the macular hole was getting small and VA improved. Six months later, the macular hole was treated spontaneously with the attached hyaloid membrane to the macula by OCT and the BCVA improved to 20/20. Fourteen months after the first visit, the BCVA decreased to 20/50 and the patient was diagnosed with stage 4 macular hole with complete PVD. OCT showed full-thickness macular hole with a LHEP in the right eye. After 25G-gauge vitrectomy with the peeling of internal limiting membrane (ILM) and LHEP, the macular hole was closed and BCVA finally improved to 20/25. Spontaneous macular hole closure without PVD may rarely occur in patients with LHEP. The surgical removal of ILM and LHEP may contribute to the successful macular hole closure after vitrectomy.

The SD-OCT Characteristics After 577nm Laser Membranotomy of Sub-inner Limiting Membrane Hemorrhage

2021 ◽  
Author(s):  
Yongpeng Zhang ◽  
Jipeng Li ◽  
Xusheng Cao ◽  
Haiying Zhou ◽  
Liyun Jia ◽  
...  
Keyword(s):  
Laser Treatment ◽  
Macular Hole ◽  
Epiretinal Membrane ◽  
Fundus Photography ◽  
Outer Retina ◽  
Ocular Fundus ◽  
Distinctive Features ◽  
Inner Limiting Membrane ◽  
Series Study ◽  
Sd Oct

Abstract Background We investigate the SD-OCT features of sub-inner limiting membrane (sub-ILM) hemorrhage after 577nm laser membranotomy. Methods The ocular fundus photography and SD-OCT of patients who received 577nm laser membranotomy for sub-ILM hemorrhage were assessed from January 2017 to March 2021 in this retrospective cases series study. Results Total of 7 patients (7 eyes) were enrolled in this study, in which 3 were female and 4 were male. The SD-OCT of ILM after laser treatment showed two distinctive features: the ILM falling back to retina (4 cases) or persistent unsealed ILM which forming premacular cavity (3 cases). The SD-OCT of macular fovea after laser treatment showed three features: normal contour (3 cases), macular hole (1 cases) and epiretinal membrane (1 case). The outer retina showed “peg-like” or “patchy-like” structure on the site of ILM attached to retina.Conclusions 577nm laser is effective in treating of sub-ILM hemorrhage and SD-OCT is effective for diagnosis and following-up of sub-ILM hemorrhage.

Modified Vitreous Surgery for Symptomatic Lamellar Macular Hole With Epiretinal Membrane Containing Macular Pigment

Retina ◽  
2013 ◽  
Vol 33 (6) ◽  
pp. 1263-1269 ◽  
Author(s):  
Fumio Shiraga ◽  
Ippei Takasu ◽  
Kouki Fukuda ◽  
Tomoyoshi Fujita ◽  
Ayana Yamashita ◽  
...  
Keyword(s):  
Macular Hole ◽  
Epiretinal Membrane ◽  
Macular Pigment ◽  
Lamellar Macular Hole ◽  
Vitreous Surgery

A Double Inverted Flap Surgical Technique for the Treatment of Idiopathic Lamellar Macular Hole Associated with Atypical Epiretinal Membrane

2019 ◽  
Vol 242 (1) ◽  
pp. 49-58 ◽  
Author(s):  
Rino Frisina ◽  
Raffaele Parrozzani ◽  
Elisabetta Pilotto ◽  
Edoardo Midena
Keyword(s):  
Surgical Technique ◽  
Macular Hole ◽  
Epiretinal Membrane ◽  
Lamellar Macular Hole

Surgical treatment of lamellar macular hole secondary to epiretinal membrane

2013 ◽  
Vol 251 (12) ◽  
pp. 2681-2688 ◽  
Author(s):  
Jen-Pin Sun ◽  
San-Ni Chen ◽  
Chih-Chun Chuang ◽  
Chao-Wen Lin ◽  
Chun-Ju Lin ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Macular Hole ◽  
Epiretinal Membrane ◽  
Lamellar Macular Hole

scholarly journals Protective effects of essential oil from Fructus Alpiniae zerumbet on retinal Müller gliosis via the PPAR-γ-p-CREB signaling pathway

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Hong Yang ◽  
Shiquan Gan ◽  
Zhaohui Jiang ◽  
Xiaomei Song ◽  
Tingting Chen ◽  
...  
Keyword(s):  
Essential Oil ◽  
Signaling Pathway ◽  
Vision Loss ◽  
Umbilical Vein ◽  
Ectopic Expression ◽  
Müller Cell ◽  
Protective Effects ◽  
Neuroprotective Effects ◽  
Ppar Γ ◽  
Muller Cell

Abstract Background Diabetic retinopathy (DR) involves extensive retinal damage and is one of the most common and serious complications of diabetes mellitus. Hyperglycemia is the major pathological trigger for diabetic complications. Müller cell gliosis, a key pathophysiological process in DR, could finally lead to vision loss. Our previous finding revealed that the essential oil of Fructus Alpiniae zerumbet (EOFAZ) protects human umbilical vein endothelial cells (HUVECs) against high glucose (HG)-induced injury via the PPAR-γ signal. However, Whether EOFAZ could prevent HG-induced Müller cell gliosis through the PPAR signaling remains unclear. Methods The neuroprotective effects of EOFAZ were evaluated in HG-treated rat retinal Müller cells (RMCs) and DR rat model. Result GFAP and VEGF upregulation is the biomarker of Müller glial reactivity gliosis. Results suggested that EOFAZ could remarkably ameliorate retinal reactive gliosis by suppressing p-CREB and GFAP and VEGF downstream effectors. Its effects on PPAR-γ, a major target for currently available anti-diabetes drugs, were also investigated. EOFAZ treatment remarkably attenuated the reduction of PPAR-γ and high level of p-CaMK II and p-CREB in HG-treated RMCs and diabetic rats. Furthermore, the activation and ectopic expression of PPAR-γ downregulated p-CREB and p-CaMK II in HG-treated RMCs. By contrast, CaMK II inhibitor KN93 and CREB gene silencing did not significantly affect the PPAR-γ expression. Conclusions A novel PPAR-γ-p-CREB signaling pathway accounts for the inhibitory effect of EOFAZ on RMCs gliosis. These findings provide scientific evidence for the potential use of EOFAZ as a complementary and alternative medicine for DR prevention and treatment in the future.

scholarly journals Spontaneous Closure of a Fully Developed Macular Hole in a Severely Myopic Eye

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
C. Bruè ◽  
I. Rossiello ◽  
J. M. Guidotti ◽  
C. Mariotti
Keyword(s):  
Visual Acuity ◽  
Macular Hole ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Spontaneous Closure ◽  
Macular Holes ◽  
The Right ◽  
Sd Oct

Purpose.Myopic macular holes can be difficult to close with surgery and are frequently associated with retinal detachment. We report on a case of a macular hole in a severely myopic eye that underwent spontaneous closure.Methods.An observational case study.Results.A 55-year-old female was referred to Ophthalmology for a central scotoma and metamorphopsia in the right eye. Visual acuity was 1/20 in both eyes. Fundus examination showed loss of the foveal depression, with a small yellow ring in the center of the fovea in the right eye, and a tilted optic disc and peripapillary staphyloma bilaterally. Spectral domain optical coherence tomography (SD-OCT) revealed a fully developed macular hole with a rim of thickened and slightly elevated retina in the right eye. The patient refused surgery. After 4 years of follow-up, her visual acuity improved to 20/40 in the right eye, and SD-OCT revealed spontaneous sealing of the macular hole without bare retinal pigment epithelium.Conclusions.Myopic macular holes represent a challenge regarding their management, and the prognosis is often poor.

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