RESOLUTION OF A CHOROIDAL ABSCESS IN THE SETTING OF ENDOPHTHALMITIS IN AN IMMUNOCOMPETENT HOST WITH NONINVASIVE TREATMENT

2012 ◽  
Vol 6 (2) ◽  
pp. 184-186
Author(s):  
Naina Gupta ◽  
Rishi P. Singh
Keyword(s):  
Immunocompetent Host ◽  
Noninvasive Treatment ◽  
Choroidal Abscess

scholarly journals Prediction of the requirement of open reduction for developmental dysplasia of the hip

2017 ◽  
Vol 46 (1) ◽  
pp. 54-61 ◽  
Author(s):  
Nabil Alassaf
Keyword(s):  
Open Reduction ◽  
Area Under The Curve ◽  
Internal Validity ◽  
Developmental Dysplasia ◽  
Estimation Model ◽  
Cross Sectional ◽  
Noninvasive Treatment ◽  
Dysplasia Of The Hip ◽  
Logistic Regression Equation ◽  
Objective Tool

Objective Closed reduction (CR) is a noninvasive treatment for developmental dysplasia of the hip (DDH), and this treatment is confirmed intraoperatively. This study aimed to develop a preoperative estimation model of the probability of requiring open reduction (OR) for DDH. Methods The study design was cross-sectional by screening all patients younger than 2 years who had attempted CR between October 2012 and July 2016 by a single surgeon. Potential diagnostic determinants were sex, age, side, bilaterality, International Hip Dysplasia Institute (IHDI) grade, and acetabular index (AI). An intraoperative arthrogram was the reference standard. A logistic regression equation was built from a reduced model. Bootstrapping was performed for internal validity. Results A total of 164 hips in 104 patients who met the inclusion criteria were analysed. The prevalence of CR was 72.2%. Independent factors for OR were older age, higher IHDI grade, and lower AI. The probability of OR = 1/[1 + exp − (−2.753 + 0.112 × age (months) + 1.965 × IHDI grade III (0 or 1) + 3.515 × IHDI grade IV (0 or 1) − 0.058 × AI (degrees)]. The area under the curve was 0.79. Conclusion This equation is an objective tool that can be used to estimate the requirement for OR.

scholarly journals Short Onset and Enhanced Analgesia Following Nasal Administration of Non-Controlled Drugs in Nanovesicular Systems

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 978
Author(s):  
Elka Touitou ◽  
Hiba Natsheh ◽  
Shatha Boukeileh ◽  
Rania Awad
Keyword(s):  
Lipid Bilayers ◽  
Analgesic Effect ◽  
Drug Level ◽  
Nasal Delivery ◽  
Nasal Administration ◽  
Mice Model ◽  
Noninvasive Treatment ◽  
New Approach ◽  
Controlled Drugs ◽  
Peak Value

Nasal nanovesicular delivery systems (NVS) containing the noncontrolled analgesic drugs Ketoprofen, Butorphanol or Tramadol, incorporated in a phospholipid nanovesicular carrier, were designed and investigated. The systems were first characterized for their physicochemical properties. Due to their composition, comprising propylene glycol as a lipid bilayers fluidizer, these systems contain soft vesicles. Pharmacokinetic profiles of Tramadol in plasma and brain and of Ketoprofen in plasma were also assessed. The analgesic effect of each of the three tested drugs was evaluated in the acetic acid mice model for pain. One important result obtained in this work is that the concentration of Tramadol in rats’ plasma and brain increased rapidly after administration, reaching a peak value 10 min after administration with a Cmax of 2 to 5 folds greater than that for the oral or nasal non-vesicular treatments, respectively. In the case of Ketoprofen, the peak of the drug level in plasma was measured 10 min post nasal administration in NVS. The Cmax was three-fold higher relative to oral administration of this drug. In the experiment testing analgesia, a rapid and improved analgesia was observed for the tested drugs when delivered nasally in the nanocarrier. On the other hand, a weaker analgesic effect was observed for oral and nasal control systems. This new approach suggests that nasal delivery of non-controlled drugs in soft nanovesicles may open the way for better and noninvasive treatment of severe pain.

scholarly journals Clinical effectiveness and potential long-term benefits of high-intensity focused ultrasound therapy for patients with adenomyosis

2020 ◽  
Vol 48 (12) ◽  
pp. 030006052097649
Author(s):  
Wei Li ◽  
Jiayu Mao ◽  
Yang Liu ◽  
Ying Zhu ◽  
Xiaojing Li ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Clinical Effectiveness ◽  
Treatment Method ◽  
Mean Difference ◽  
High Intensity Focused Ultrasound ◽  
Noninvasive Treatment ◽  
Numerical Rating

Objectives Adenomyosis is a common and refractory disease in gynecology. Preserving the uterus during treatment for adenomyosis remains a problem. High-intensity focused ultrasound (HIFU) is widely used in treatment of solid tumors. This study aimed to analyze patients with adenomyosis who were treated by HIFU and to preliminarily examine the characteristics of patients who are more suitable for HIFU to treat adenomyosis with reliable efficacy. Methods Over 2 years, 67 women who were diagnosed with adenomyosis and treated with HIFU at our gynecology department were included in this study. We investigated outcomes of their symptoms (dysmenorrhea and hypermenorrhea) and the volume of their uterine lesions. We also compared the patients’ clinical profiles. Results The women had a mean follow-up duration of 11.6 ± 0.46 months. In the numerical rating scale, used to assess the degree of dysmenorrhea, the score was significantly lower (mean difference: −1.94, 95% confidence interval: −2.704 to −1.176) 3 months after HIFU treatment compared with before treatment, then it remained stable for 3 to 12 months. Hypermenorrhea was reduced to a certain degree, with a mean difference of −0.54 (−1.01–0.02). Conclusions HIFU is a new noninvasive treatment method for adenomyosis that may help relieve dysmenorrhea.

scholarly journals Patient With Unresectable Cholangiocarcinoma Treated With Radiofrequency Hyperthermia in Combination With Chemotherapy: A Case Report

2017 ◽  
Vol 17 (2) ◽  
pp. 558-561 ◽  
Author(s):  
Juyoung Ryu ◽  
Kangwook Lee ◽  
Changmug Joe ◽  
JongCheon Joo ◽  
Namhun Lee ◽  
...  
Keyword(s):  
Case Report ◽  
Treatment Option ◽  
Carbohydrate Antigen ◽  
Klatskin Tumor ◽  
Preoperative Radiation ◽  
Noninvasive Treatment ◽  
Patients With Cancer ◽  
Radiofrequency Hyperthermia ◽  
Promising Treatment ◽  
Tomography Scan

Hyperthermia, which is a noninvasive treatment that causes tumor cells to become heated and that works in synergy with anticancer drugs and radiation therapy, is emerging as a promising treatment for patients with cancer. The purpose of this study is to report the efficacy of hyperthermia combined with chemotherapy (gemcitabine/cisplatin) for the treatment of a patient with unresectable cholangiocarcinoma. A 54-year-old man was diagnosed as hilar cholangiocarcinoma (Klatskin tumor) and was administered neoadjuvant and preoperative radiation with chemotherapy. However, because the treatment with radiation and chemotherapy was not successful, he decided to undergo hyperthermia combined with chemotherapy as a second treatment option. He was suffering from fatigue, dyspepsia, epigastralgia, and jaundice. Hyperthermia combined with chemotherapy was administered 32 times over a period of 4 months. The patient experienced no critical complications, and the patient’s condition improved, with the carbohydrate antigen 19-9 (CA 19-9) and the total bilirubin levels being relatively lowered. In addition, the computed tomography scan showed that the cholangiocarcinoma had not progressed. In conclusion, this case report suggests radiofrequency hyperthermia combined with chemotherapy may be a promising treatment option for patients with unresectable cholangiocarcinoma.

scholarly journals A Rare Presentation of ConcurrentScedosporium apiospermumandMadurella griseaEumycetoma in an Immunocompetent Host

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Vivek Gulati ◽  
Seun Bakare ◽  
Saket Tibrewal ◽  
Nizar Ismail ◽  
Junaid Sayani ◽  
...  
Keyword(s):  
Subcutaneous Tissue ◽  
Sensu Stricto ◽  
Scedosporium Apiospermum ◽  
Immunocompetent Host ◽  
Rare Presentation ◽  
Atypical Case ◽  
Granulomatous Infection

Mycetoma is a disfiguring, chronic granulomatous infection which affects the skin and the underlying subcutaneous tissue. We present an atypical case of recurrent mycetoma without ulceration, in a 35-year-old immunocompetent male caused byScedosporium apiospermumsensu stricto andMadurella grisea, occurring at two separate anatomical sites.

scholarly journals Strongyloides Colitis in an Immunocompetent Host Transmitted Through Sexual Contact: Report of a Case and Review of the Literature

2012 ◽  
Vol 138 (suppl 1) ◽  
pp. A106-A106
Author(s):  
Jaclyn F. Hechtman ◽  
Mohammad Raoufi ◽  
Michael Diaz ◽  
James George ◽  
Hongfa Zhu
Keyword(s):  
Sexual Contact ◽  
Review Of The Literature ◽  
Immunocompetent Host

scholarly journals Polymicrobial Sepsis in an Immunocompetent Host due to Self Injection of Urine

2011 ◽  
Vol 3 (3) ◽  
pp. 322
Author(s):  
Senthilkumaran Subramanian ◽  
Sweni Shah ◽  
Balamurugan Namasivayam ◽  
Thirumalaikolundusubramanian Ponniah
Keyword(s):  
Polymicrobial Sepsis ◽  
Immunocompetent Host

Case Report: A Great Mimicker of Neoplasm: Pulmonary Cryptococcosis in an Immunocompetent Host After High-Altitude Descent

2021 ◽  
Author(s):  
Keely Johnson ◽  
Umaima Dhamrah ◽  
Aisha Amin ◽  
Joseph Masci
Keyword(s):  
New York ◽  
High Altitude ◽  
Acid Fast Bacillus ◽  
Chest Imaging ◽  
Immunocompetent Host ◽  
Pleuritic Chest Pain ◽  
Pulmonary Cryptococcosis ◽  
Radiological Findings ◽  
Travel History ◽  
Fluconazole Therapy

Cryptococcus exposure in certain global regions is common and yet virulence in the immunocompetent host remains rare. Radiological findings of pulmonary cryptococcosis may include nonspecific lung nodules or masses indistinguishable from lung cancer or pulmonary tuberculosis. We present a case of an immunocompetent diabetic female who presented with progressively worsening pleuritic chest pain and cough with travel between Tibet and New York 2 months earlier. Chest imaging demonstrated a large lobulated mass, acid-fast bacillus smears were negative, and our patient underwent pulmonary biopsy, which grew rare budding yeast later confirmed by mucicarmine staining as Cryptococcus. Our patient was successfully treated with fluconazole therapy. We hypothesize that the high altitude of Tibet may allow for clinical latency followed by symptomatic reactivation on descent. A raised index of suspicion for pulmonary cryptococcosis with careful attention to travel history is expected to facilitate timely diagnosis.

scholarly journals Fulminant invasive aspergillosis of the mediastinum in an immunocompetent host: a case report

2012 ◽  
Vol 6 (1) ◽  
Author(s):  
Muhammad Tariq Shakoor ◽  
Samia Ayub ◽  
Zunaira Ayub ◽  
Faisal Mahmood
Keyword(s):  
Case Report ◽  
Invasive Aspergillosis ◽  
Immunocompetent Host
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