Elevated Serum Immunoglobulin G Titers Against Chlamydia pneumoniae in Primary Open-Angle Glaucoma Patients Without Systemic Disease

Purpose: To evaluate the clinical characteristics of newly diagnosed pseudoexfoliative glaucoma and compare them with those pertaining to newly diagnosed primary open-angle glaucoma as well as pseudoexfoliation syndrome. Methods: This case–control study involved 306 participants, including patients with newly diagnosed pseudoexfoliative glaucoma, age- and sex-matched normal controls, patients with newly diagnosed primary open-angle glaucoma, and subjects with pseudoexfoliation syndrome. The study was conducted at the Glaucoma Department of Clinic for Eye Diseases, Clinical Center of Serbia, as the referral center for glaucoma in Serbia. Results: The mean age in the pseudoexfoliative glaucoma, primary open-angle glaucoma, pseudoexfoliation syndrome, and normal control groups was 73.61 ± 8.46, 65.50 ± 8.97, 74.81 ± 6.80, and 73.58 ± 9.34 years, respectively (pseudoexfoliative glaucoma vs primary open-angle glaucoma, p < 0.001). Unilateral pseudoexfoliative glaucoma was diagnosed in 35 patients (42.2%). The intraocular pressure was higher in the eyes affected by pseudoexfoliative glaucoma (32.0 ± 9.5 mmHg) than that in the primary open-angle glaucoma eyes (28.8 ± 5.9 mmHg) (p < 0.001). In pseudoexfoliative glaucoma and primary open-angle glaucoma eyes, glaucoma severity was determined via the vertical cup-to-disk ratio (C/D) 0.65 (0.45–1.0) versus 0.60 (0.45–1.0), p = 0.048 and visual field mean deviation −5.68 (−1.58 to −30.9) versus −4.70 (−1.39 to −31.0), p = 0.045. Alzheimer’s was the only systemic disease associated with pseudoexfoliative glaucoma in the study sample, with an odds ratio of 0.021 (95% confidence interval = 0.00−21.52, p = 0.022). Conclusion: At the time of diagnosis, pseudoexfoliative glaucoma exhibits different clinical features compared with primary open-angle glaucoma. Higher intraocular pressure, narrow or occludable angle, increased trabecular pigmentation, phacodonesis, and poorer pupillary dilatation emerged as the factors associated with pseudoexfoliative glaucoma.

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Lack of Association between Variant rs7916697 in ATOH7 and Primary Open Angle Glaucoma in a Saudi Cohort

Genetics Research International ◽

10.1155/2018/2148056 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6

Author(s):

Altaf A. Kondkar ◽

Taif A. Azad ◽

Faisal A. Almobarak ◽

Ibrahim M. Bahabri ◽

Hatem Kalantan ◽

...

Keyword(s):

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Systemic Disease ◽

Allelic Association ◽

Bhlh Transcription Factor ◽

Open Angle ◽

Clinical Phenotypes ◽

Genotype Effect ◽

Significant Difference ◽

Clinical Indices

A case-control genetic association study was performed to investigate whether variant rs7916697 in atonal bHLH transcription factor 7 (ATOH7), which has been previously reported to be associated with optic disc parameters and primary open angle glaucoma (POAG) in different ethnic groups, is a risk factor for POAG or any of its clinical phenotypes in a Saudi cohort. Genotyping of rs7916697 (G>A) variant was performed in 186 unrelated POAG cases and 171 unrelated nonglaucomatous controls of Saudi origin using real-time Taq-Man® assay. Genotypic and allelic association with POAG and its related clinical indices were evaluated. Demographic and systemic disease status did not differ significantly between POAG cases and controls. Association analysis between POAG cases and controls showed no significant genotype effect under additive (p=0.707), dominant (p=0.458), and recessive (p=0.554) models. Besides, the minor ‘A’ allele frequency was 0.39 in POAG cases and 0.36 in controls with no significant distribution (p=0.406). In addition, there was no significant difference between genotypes and clinical phenotypes such as intraocular pressure and cup/disc ratio within the POAG group, or any age and sex adjusted genotype effect on the disease outcome in regression analysis. Variant rs7916697 in ATOH7 is not associated with POAG or its clinical indices such as IOP and cup/disc ratio in a Saudi cohort.

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The course of primary open angle glaucoma in a patient with subcompensated non-insulin dependent diabetes type 2

Clinical Medicine (Russian Journal) ◽

10.30629/0023-2149-2021-99-2-141-145 ◽

2021 ◽

Vol 99 (2) ◽

pp. 141-145

Author(s):

O. V. Gaponko ◽

A. V. Kuroyedov ◽

N. M. Solnov ◽

V. V. Gorodnichy ◽

S. V. Diordiychuk ◽

...

Keyword(s):

Diabetes Mellitus ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Systemic Disease ◽

Diabetes Type 2 ◽

Glaucoma Surgery ◽

Hypotensive Effect ◽

Open Angle ◽

Choice Of Treatment ◽

Blood Aqueous Barrier

Оphthalmic manifestations of diabetes mellitus include changes in the circulation of aqueous humor, increase or decrease in the level of intraocular tension, abnormal permeability of the blood-aqueous barrier, and anomalies of the retinal vessels. A balanced approach to the choice of treatment tactics is a basis for treatment of Primary Open Angle Glaucoma. The criterion for the effectiveness of glaucoma surgery is sustained normalization of intraocular tension and preservation of visual functions. Surgical treatment of glaucoma in patients with severe somatic pathology is accompanied by a high risk of postoperative complications: hyphema, ciliochoroidal detachment, hemophthalmos, repeated increase in intraocular tension, etc. Diabetes mellitus as a systemic disease causes widespread vascular autonomic and endothelial dysfunction. The reasons for the decrease in the hypotensive effect of glaucoma surgery in such patients is excessive cicatrization of the newly created fluid outflow tracts with the formation of adhesions between the conjunctiva and the sclera, the scleral flap and underlying tissues. It leads to a repeated increase in intraocular tension in the late postoperative period. Therefore, the choice of tactics for the management and treatment of patients with glaucoma and with severe comorbidity requires an individual and measured approach.

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Elevated Plasma Level of 8-Hydroxy-2′-deoxyguanosine Is Associated with Primary Open-Angle Glaucoma

Journal of Ophthalmology ◽

10.1155/2020/6571413 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Altaf A. Kondkar ◽

Taif A. Azad ◽

Tahira Sultan ◽

Essam A. Osman ◽

Faisal A. Almobarak ◽

...

Keyword(s):

Dna Damage ◽

Roc Curve ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Systemic Disease ◽

Enzyme Linked Immunosorbent Assay ◽

Open Angle ◽

Elevated Plasma ◽

Potential Biomarker ◽

Significant Difference

Purpose. To determine the association between plasma 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels, a marker for oxidative DNA damage, and patients with primary open-angle glaucoma (POAG) or its clinical phenotypes. Furthermore, we also examined the utility of plasma 8-OHdG as a potential biomarker in POAG. Materials and Methods. In a retrospective case-control study, plasma samples were obtained from 50 POAG cases and 45 glaucoma-free controls matched for age, sex, and ethnicity. 8-OHdG levels were measured in duplicate using an enzyme-linked immunosorbent assay (ELISA) on an automated ELISA analyzer. Results. There was no significant difference in age, sex, and systemic disease distribution between POAG cases and controls. Both mean and median 8-OHdG levels were significantly elevated in POAG cases and male subjects. The area under the receiver operating characteristic (ROC) curve value for plasma 8-OHdG was 0.653 (95% confidence interval = 0.54–0.76, p=0.010). The cutoff values based on quartile distribution and ROC curve analysis showed that elevated plasma 8-OHdG significantly increased the risk of POAG by more than 4-folds. Plasma 8-OHdG had a sensitivity of 78% and specificity of 53%. In logistic regression analysis, 8-OHdG showed a significant effect on POAG outcome (p=0.016) independent of age, sex, smoking, and systemic diseases. However, no significant correlation was observed between 8-OHdG and specific clinical markers of glaucoma such as intraocular pressure (p=0.699), cup/disc ratio (p=0.213), and the number of antiglaucoma medications (p=0.603). Conclusion. The study shows that there is a significant association between elevated plasma 8-OHdG and POAG, supporting the role of systemic oxidative stress-induced DNA damage in POAG pathogenesis. However, with a high rate of false-positivity, plasma 8-OHdG may lack the ability to serve as a potential biomarker in POAG. Further studies in a much larger cohort are needed to confirm these findings.

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Is primary open-angle glaucoma an ocular manifestation of systemic disease?

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-019-04239-9 ◽

2019 ◽

Vol 257 (4) ◽

pp. 665-673 ◽

Cited By ~ 4

Author(s):

Stephanie Wey ◽

Sarah Amanullah ◽

George L. Spaeth ◽

Melih Ustaoglu ◽

Kamran Rahmatnejad ◽

...

Keyword(s):

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Systemic Disease ◽

Open Angle ◽

Ocular Manifestation

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Clinical efficacy of osteopathic correction in the complex treatment of patients with unoperated open-angle glaucoma

Russian Osteopathic Journal ◽

10.32885/2220-0975-2019-3-4-97-105 ◽

2020 ◽

pp. 97-105

Author(s):

E. N. Simakova ◽

O. V. Stenkova

Keyword(s):

Intraocular Pressure ◽

Drug Therapy ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Randomized Study ◽

Main Group ◽

Control Group ◽

Open Angle ◽

Complex Treatment ◽

Hypotensive Drug

Introduction. Glaucoma is one of the most significant eye diseases. It is often diagnosed, not always amenable to therapy, and can lead to a complete loss of visual functions. In recent years, the method of osteopathic correction has become widespread as one of the effective methods of treatment and rehabilitation of patients with pathologies of various body systems. In the pathogenesis of glaucoma, it is customary to distinguish a dystrophic concept, which considers primary open-angle glaucoma as a result of dystrophic changes in the connective tissue, as well as in the endothelial lining of the trabeculae and Schlemm′s canal, especially destructive changes in mitochondria and the alteration of their functional activity. A vascular concept is also distinguished. According to this concept, the central link in the pathogenesis of glaucoma is circulatory disorder in the ciliary vessels, ocular artery, and major vessels of the head and neck, it can be assumed that osteopathic correction in the treatment of patients with open-angle glaucoma will be pathogenetically substantiated and will have a positive effect on intraocular pressure and trophicity of the optic nerve. The goal of research — to study the influence of in osteopathic correction on the nature of unoperated glaucoma (stage IIA) and to substantiate the possibility of using osteopathic correction in the complex treatment of patients with this pathology.Materials and methods. A prospective controlled randomized study was conducted at 52 city polyclinics, branch 3, Moscow, from January 2018 to January 2019. 40 patients (70 eyes) aged 50 to 75 years with primary open-angle glaucoma IIA stage were examined. At this stage of the disease, patients most often seek medical care and the issue of conservative management is primarily considered. All patients were divided into two groups of 20 people: the main group and the control group. The treatment in the main group included hypotensive drug therapy and osteopathic correction. Patients of the control group received only drug therapy. All patients underwent ophthalmic (visometry, tonometry, perimetry) and osteopathic examination twice: before the treatment and after 3 months.Results. For patients with primary open-angle IIA non-operated glaucoma, regional (most often regions of the head, neck, dura mater) and local (abdominal diaphragm, iliac bones, hip and knee joints) somatic dysfunctions were the most typical. In the main group a statistically significant decrease in the frequency and severity of dysfunctions at all levels was stated. Also, in patients receiving osteopathic correction, a significant decrease in the level of intraocular pressure and perimetric indices was noted. In patients of the control group, no reliable changes in these indicators were obtained.Conclusion. The results obtained indicate that osteopathic correction is clinically effective in the complex treatment of patients with primary open-angle II A glaucoma.

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