Diagnosis and Screening for Cytomegalovirus Infection in Pregnant Women in Cuba as Prognostic Markers of Congenital Infection in Newborns

2010 ◽  
Vol 29 (12) ◽  
pp. 1105-1110 ◽  
Author(s):  
Vivian Kourí ◽  
Consuelo B. Correa ◽  
Denis Verdasquera ◽  
Pedro Ariel Martínez ◽  
Alina Alvarez ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Cytomegalovirus Infection ◽  
Prognostic Markers ◽  
Congenital Infection

scholarly journals Identification of pregnancies at risk from cytomegalovirus infection

1977 ◽  
Vol 79 (3) ◽  
pp. 347-354 ◽  
Author(s):  
L. M. de Silva ◽  
G. L. Kampfner ◽  
C. M. Lister ◽  
J. O.'H. Tobin
Keyword(s):  
At Risk ◽  
Pregnant Women ◽  
Infection Rate ◽  
Cytomegalovirus Infection ◽  
Fluorescent Antibody ◽  
Congenital Infection ◽  
Fluorescent Antibody Technique ◽  
Serum Samples ◽  
Antibody Technique ◽  
Virus Excretion

SUMMARYThe fluorescent antibody technique was used for the identification of specific cytomegalovirus IgM in the sera of twenty-four of 1065 unmarried pregnant women. Seventeen of them were followed to term and five infected infants were identified. Two other infants had CMV IgM in neonatal serum samples but virus excretion was not demonstrated. The congenital infection rate in this study was 5·3 per 1000 births by virus excretion and 7·9 per 1000 if cases with specific IgM are included; from previous studies a rate of 8·8 per 1000 was expected. The reasons for the lack of relationship between specific IgM in the mothers' serum and infected babies is discussed.

The role of the virological tests in the diagnosis of the cytomegalovirus infection during pregnancy

2014 ◽  
Vol 155 (41) ◽  
pp. 1632-1642
Author(s):  
Ilona Mihály ◽  
Zsuzsanna Arányi ◽  
Gyula Prinz ◽  
Adrienne Lukács ◽  
Tímea Kolozsi ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Cytomegalovirus Infection ◽  
Congenital Infection ◽  
Diagnostic Tools ◽  
Test Results ◽  
Cytomegalovirus Disease ◽  
Fetal Ultrasound ◽  
Recent Infection ◽  
Medical Specialties

Introduction: The most harmful and most frequent foetal agent is cytomegalovirus. The progress in diagnostic tools and therapeutic opportunities opened new perspectives in the diagnosis and management of foetal cytomegalovirus infection. Aim: Evaluation of cytomegalovirus virological test results performed during pregnancy between 2007 and 2012. Method: Clinical and virology data were retrospectively analysed. Results: 64.5% of the 956 tested women were serologically protected and 33.3% were susceptible to cytomegalovirus. Recent infection was confirmed in 10 pregnant women, while the infection could not be confirmed or excluded in 3 pregnant women. Six pregnant women were asymptomatic, 5 had typical disease, and 2 had abnormal fetal ultrasound. One fetus aborted, congenital infection was confirmed in 2, and was excluded in one of the four newborns tested. Conclusions: The immunity of women to cytomegalovirus reflects high socioeconomic circumstances. Confimatory tests must be done both in women who have cytomegalovirus disease and those who have IgM positive result detected by enzyme (linked) immunoassay. Screening must be done prior to pregnancy. Strict collaboration between professionals of different medical specialties is necessary. Orv. Hetil., 2014, 155(41), 1632–1642.

FETAL GROWTH RESTRICTION WITH EARLY AND LATE MANIFESTATION, PROGNOSTIC MARKERS

2020 ◽  
pp. 27-30
Author(s):  
Yakubova D.I.
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Prenatal Screening ◽  
Prognostic Markers ◽  
Growth Restriction ◽  
Late Manifestation ◽  
Late Form ◽  
Early Manifestation

Objective of the study: Comprehensive assessment of risk factors, the implementation of which leads to FGR with early and late manifestation. To evaluate the results of the first prenatal screening: PAPP-A, B-hCG, made at 11-13 weeks. Materials and Methods: A retrospective study included 110 pregnant women. There were 48 pregnant women with early manifestation of fetal growth restriction, 62 pregnant women with late manifestation among them. Results of the study: The risk factors for the formation of the FGR are established. Statistically significant differences in the indicators between groups were not established in the analyses of structures of extragenital pathology. According to I prenatal screening, there were no statistical differences in levels (PAPP-A, b-hCG) in the early and late form of FGR.

Improving diagnosis of primary cytomegalovirus infection in pregnant women using immunoblots

2012 ◽  
Vol 85 (2) ◽  
pp. 315-319 ◽  
Author(s):  
Harshita Rajasekariah ◽  
Gillian Scott ◽  
Peter W. Robertson ◽  
William D. Rawlinson
Keyword(s):  
Pregnant Women ◽  
Cytomegalovirus Infection ◽  
Primary Cytomegalovirus Infection

Psychomotor Development After Ganciclovir Selectively Treated Congenital And Perinatal Cytomegalovirus Infection

Folia Medica ◽  
2012 ◽  
Vol 54 (4) ◽  
pp. 37-44 ◽  
Author(s):  
Ivan S. Ivanov ◽  
Nikolay T. Popov ◽  
Rumyana I. Moshe ◽  
Elena V. Chepisheva ◽  
Ina E. Geneva ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Auditory Evoked Potentials ◽  
Risk Group ◽  
Congenital Infection ◽  
Psychomotor Development ◽  
Control Group ◽  
Serological Screening ◽  
Cytomegalic Inclusion Disease ◽  
Development Delay ◽  
Systemic Manifestations

Abstract AIM: To study the development of children with selectively treated cytomegalovirus infection. PATIENTS AND METHODS: We studied prospectively a risk group of 12 children with cytomegalovirus infection. These children were diagnosed by serological screening in the first three months after birth and are defined as congenital and perinatal infections. Thirteen infants with no serological evidence of previous or present cytomegalovirus infection at 4 - 12 months of age were used as controls. Ganciclovir in a dose of 10-15 mg/kg/day for at least 2 weeks followed by 5-7.5 mg/kg/day administered intravenously for at least 2 weeks more was given to 4 children from the risk group with PCR confirmed cytomegalovirus infection: to one with suspected congenital infection that presented with encephalitis, to two children with abnormal auditory evoked potentials (AEPs) and other non-neurological symptoms of a suspected congenital infection, and to one child with proven congenital infection with systemic manifestations. There was no infant with cytomegalic inclusion disease in the study. All other children in the risk group that had clinically manifested infection received isoprinosine in a dose of 50 mg/kg for one month. RESULTS: Psychomotor development delay at age three was found in two children from the risk group and in one child in the control group. There was no difference between the two groups regarding the frequency of paroxysmal events, sensory deficiency or frequent illnesses. CONCLUSIONS: The prognosis in cases of cytomegalovirus infection diagnosed at three years of age and treated selectively can be similar to that in infection free 3-year-old children (if there are no cases of CMV inclusion disease).

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