The role of the virological tests in the diagnosis of the cytomegalovirus infection during pregnancy

2014 ◽  
Vol 155 (41) ◽  
pp. 1632-1642
Author(s):  
Ilona Mihály ◽  
Zsuzsanna Arányi ◽  
Gyula Prinz ◽  
Adrienne Lukács ◽  
Tímea Kolozsi ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Cytomegalovirus Infection ◽  
Congenital Infection ◽  
Diagnostic Tools ◽  
Test Results ◽  
Cytomegalovirus Disease ◽  
Fetal Ultrasound ◽  
Recent Infection ◽  
Medical Specialties

Introduction: The most harmful and most frequent foetal agent is cytomegalovirus. The progress in diagnostic tools and therapeutic opportunities opened new perspectives in the diagnosis and management of foetal cytomegalovirus infection. Aim: Evaluation of cytomegalovirus virological test results performed during pregnancy between 2007 and 2012. Method: Clinical and virology data were retrospectively analysed. Results: 64.5% of the 956 tested women were serologically protected and 33.3% were susceptible to cytomegalovirus. Recent infection was confirmed in 10 pregnant women, while the infection could not be confirmed or excluded in 3 pregnant women. Six pregnant women were asymptomatic, 5 had typical disease, and 2 had abnormal fetal ultrasound. One fetus aborted, congenital infection was confirmed in 2, and was excluded in one of the four newborns tested. Conclusions: The immunity of women to cytomegalovirus reflects high socioeconomic circumstances. Confimatory tests must be done both in women who have cytomegalovirus disease and those who have IgM positive result detected by enzyme (linked) immunoassay. Screening must be done prior to pregnancy. Strict collaboration between professionals of different medical specialties is necessary. Orv. Hetil., 2014, 155(41), 1632–1642.

scholarly journals Cytomegalovirus congenital infection – cause of neurosensorial hearing loss

2016 ◽  
Vol 19 (2) ◽  
pp. 50-53
Author(s):  
Dana-Teodora Anton-Păduraru ◽  
◽  
Ana Simona Drochioi ◽  
Delia Bizim ◽  
Angelica-Cristina Marin ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Cytomegalovirus Infection ◽  
Strong Predictor ◽  
Public Health Problem ◽  
Congenital Infection ◽  
Major Public Health Problem ◽  
Seroprevalence Rate ◽  
Specific Symptoms ◽  
The Relationship

Cytomegalovirus infection is a major public health problem, because annually there are born increasingly more children with this infection. Numerous studies have shown that cytomegalovirus infection is an important cause of hearing loss. Cytomegalovirus infection specific symptoms present at birth are a strong predictor for hearing loss, even in populations with low maternal seroprevalence rate. The severity of deafness due to cytomegalovirus infection is variable. Pathophysiology of deafness caused by cytomegalovirus infection is not well known, the mechanisms possible involved being impaired endolymphatic structures, cytopathic effect of the virus and the host response to the inner ear structures. The relationship between viral load and increased likelihood of deafness in infants supports the role of antiviral therapy in decreasing the incidence and the severity of deafness caused by cytomegalovirus. We consider that monitoring children with congenital cytomegalovirus infection should include also hearing monitoring.

scholarly journals Development and Application of a PCR-Based Method Including an Internal Control for Diagnosis of Congenital Cytomegalovirus Infection

2000 ◽  
Vol 38 (1) ◽  
pp. 1-6
Author(s):  
Rachel N. Jones ◽  
M. Lynne Neale ◽  
Brian Beattie ◽  
Diana Westmoreland ◽  
Julie D. Fox
Keyword(s):  
Amniotic Fluid ◽  
Pregnant Women ◽  
Internal Control ◽  
Congenital Infection ◽  
Diagnostic Group ◽  
Urine Samples ◽  
Diagnostic Tools ◽  
Cmv Infection ◽  
Congenital Cmv Infection ◽  
Developed World

ABSTRACT Cytomegalovirus (CMV) is the most common cause of congenital infection in the developed world. We have designed and evaluated an assay that includes an internal control for amplification and detection of CMV DNA in amniotic fluid and neonatal urine samples. We present data on the use of this assay in the diagnosis of congenital CMV infection. A total of 145 amniotic and fetal fluid samples were examined by this assay; 83 were from healthy pregnant women and 62 were from women who were being investigated because of concerns over the pregnancy (diagnostic group). CMV DNA was detected in three amniotic fluid samples from the diagnostic group but was not detected in any samples taken from healthy pregnant women. Thirty-nine urine samples were obtained from 19 neonates with suspected congenital infection; CMV DNA was detected in urine from 6 of these patients. The assay provides useful information about CMV infection in the fetus and the neonate; when used in conjunction with other diagnostic tools it will enable mothers and obstetricians to make informed decisions about the management of pregnancies complicated by CMV infection.

RELATIONSHIP OF INTERLEUKIN-6 AND BLOOD FLOW IN THE UMBILICAL ARTERY DURING EXCERVATION OF MONO- AND MIXT-CYTOMEGALOVIRAL INFECTION IN THE SECOND TRIMESTER OF PREGNANCY

2020 ◽  
Author(s):  
Irina Andrievskaya ◽  
A Milovanov ◽  
Igor Gorikov ◽  
Inna Dovzhikova ◽  
Nataliya Ishutina
Keyword(s):  
Blood Flow ◽  
Pregnant Women ◽  
Blood Supply ◽  
Interleukin 6 ◽  
Cytomegalovirus Infection ◽  
Umbilical Artery ◽  
Second Trimester ◽  
Relationship Of ◽  
The Relationship

In order to determine the role of a cytokine in the regulation of blood supply to the placenta, the relationship between interleukin-6 (IL-6) in serum and blood flow in the umbilical artery in healthy pregnant women and during pregnancy complicated by exacerbation of mono- and mixed cytomegalovirus infection in the second trimester was studied

Diagnosis and Screening for Cytomegalovirus Infection in Pregnant Women in Cuba as Prognostic Markers of Congenital Infection in Newborns

2010 ◽  
Vol 29 (12) ◽  
pp. 1105-1110 ◽  
Author(s):  
Vivian Kourí ◽  
Consuelo B. Correa ◽  
Denis Verdasquera ◽  
Pedro Ariel Martínez ◽  
Alina Alvarez ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Cytomegalovirus Infection ◽  
Prognostic Markers ◽  
Congenital Infection

scholarly journals THE ROLE OF CHOLESTEROL AND ESTRADIOL IN THE DEVELOPMENT OF PLACENTAL INSUFFICIENCY UNDER CYTOMEGALOVIRUS INFECTION IN THE THIRD TRIMESTER OF PREGNANCY

2017 ◽  
Vol 1 (65) ◽  
pp. 54-58
Author(s):  
Наталия Ишутина ◽  
Nataliya Ishutina ◽  
Михаил Луценко ◽  
Mikhail Lutsenko ◽  
Ирина Андриевская ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Total Cholesterol ◽  
Discriminant Function ◽  
Cytomegalovirus Infection ◽  
Placental Insufficiency ◽  
Third Trimester ◽  
The Third ◽  
Limit Value ◽  
Period Of Gestation

To assess the role of cholesterol and estradiol in the development of placental insufficiency under cytomegalovirus infection (CMVI) in the period of gestation, cholesterol and estradiol were studied in the peripheral blood of 35 pregnant women who had a reactivation of chronic CMVI (IgG antibody titer to CMV is 1:1600) in the third trimester of pregnancy (the main group). As a control the blood plasma of 35 healthy women of the same period of gestation and age as in the main group were studied. It was found out that the reactivation of chronic CMVI in the third trimester of gestation was followed by the decrease of concentration of cholesterol by 23% ( p<0.001), of estradiol by 65% (p<0.001) in comparison with the values of healthy women. To analyze the chosen values for assessment, the discriminant function was found. It had the probability of differences not less than 95%; which that the discriminant equation was derived which for this study had the following formula: D=(-379×total cholesterol)+(-0.072×estradiol), where D is a discriminant function whose limit value is (-2673.59). If D is equal or less than the limit value, then the development of placental insufficiency in women in the third trimester of pregnancy is predicted, and if D is more than the limit value, then the normal course of the third trimester of pregnancy is predicted. Thus, the obtained results allow to establish the main role of disturbances of total cholesterol contents and key steroid hormone of pregnancy (estradiol) in the pathogenesis of placental insufficiency development under CMVI during gestation, which can be the basis for improvement of diagnostic and medical basis under this pathology of pregnant women.

scholarly journals Identification of pregnancies at risk from cytomegalovirus infection

1977 ◽  
Vol 79 (3) ◽  
pp. 347-354 ◽  
Author(s):  
L. M. de Silva ◽  
G. L. Kampfner ◽  
C. M. Lister ◽  
J. O.'H. Tobin
Keyword(s):  
At Risk ◽  
Pregnant Women ◽  
Infection Rate ◽  
Cytomegalovirus Infection ◽  
Fluorescent Antibody ◽  
Congenital Infection ◽  
Fluorescent Antibody Technique ◽  
Serum Samples ◽  
Antibody Technique ◽  
Virus Excretion

SUMMARYThe fluorescent antibody technique was used for the identification of specific cytomegalovirus IgM in the sera of twenty-four of 1065 unmarried pregnant women. Seventeen of them were followed to term and five infected infants were identified. Two other infants had CMV IgM in neonatal serum samples but virus excretion was not demonstrated. The congenital infection rate in this study was 5·3 per 1000 births by virus excretion and 7·9 per 1000 if cases with specific IgM are included; from previous studies a rate of 8·8 per 1000 was expected. The reasons for the lack of relationship between specific IgM in the mothers' serum and infected babies is discussed.

Microcephaly and Congenital Cytomegalovirus Infection: A Combined Prospective and Retrospective Study of a Swedish Infant Population

PEDIATRICS ◽  
1986 ◽  
Vol 78 (6) ◽  
pp. 1058-1063
Author(s):  
Karin Ahlfors ◽  
Sten-Anders Ivarsson ◽  
Ingrid Bjerre
Keyword(s):  
Head Circumference ◽  
Cytomegalovirus Infection ◽  
Laboratory Data ◽  
Congenital Infection ◽  
Transmitted Infection ◽  
Congenital Rubella ◽  
Primary Cytomegalovirus Infection ◽  
In The Beginning ◽  
The City

Microcephaly and its etiology were studied in an unselected Swedish urban infant population. Virtually, all live-born infants (14,724) born between October 1977 and December 1983 in the city of Malmö, Sweden, were included in the study. Special attention was given to the role of congenital infections, particularly to cytomegalovirus infection. The infant population was studied from two points of view. One part of the study was prospective and based on regular cytomegalovirus isolation in urine within the first week of life. About 80% of the newborns were adequately studied by this test. None of 56 infants shown to be cytomegalovirus excreters (congenitally infected) and followed up were born with or developed microcephaly (head circumference smaller than 3 SD below the mean for age and sex) during the first 1 to 7 years of life. However, two of the 56 infants had a head circumference of –2 SD. In the beginning of 1985, an inventory was made of the presence of symptomatic microcephaly in the abovementioned population still living in the city or deceased there. Of about 10,000 such children, 12 were found to have symptomatic microcephaly. By studies of personal, clinical, and laboratory data and by retrospective serologic studies of frozen pre- and postconceptional maternal sera, a possible explanation or a recognized syndrome was obtained in ten of the 12 cases. In one of them, the mother had a primary cytomegalovirus infection, possibly in early pregnancy. Although the infant had symptoms compatible with a congenital infection, no laboratory evidence of transmitted infection was found. In no case were congenital rubella virus or Toxoplasma gondii infections suspected.

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