Impact of Concurrent PIK3CA Mutations on Response to EGFR Tyrosine Kinase Inhibition in EGFR-Mutant Lung Cancers and on Prognosis in Oncogene-Driven Lung Adenocarcinomas

Egfr Tyrosine Kinase ◽

Egfr Mutant ◽

Lung Adenocarcinomas

The Role of PIK3CA Mutations among Lung Adenocarcinoma Patients with Primary and Acquired Resistance to EGFR Tyrosine Kinase Inhibition

Scientific Reports ◽

10.1038/srep35249 ◽

2016 ◽

Vol 6 (1) ◽

Cited By ~ 12

Author(s):

Shang-Gin Wu ◽

Yih-Leong Chang ◽

Chong-Jen Yu ◽

Pan-Chyr Yang ◽

Jin-Yuan Shih

Keyword(s):

Tyrosine Kinase ◽

Lung Adenocarcinoma ◽

Acquired Resistance ◽

Kinase Inhibition ◽

Pik3ca Mutations ◽

Intratumoral Heterogeneity in EGFR-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition

Cancer Research ◽

10.1158/0008-5472.can-15-0377 ◽

2015 ◽

Vol 75 (20) ◽

pp. 4372-4383 ◽

Cited By ~ 60

Author(s):

Margaret Soucheray ◽

Marzia Capelletti ◽

Inés Pulido ◽

Yanan Kuang ◽

Cloud P. Paweletz ◽

...

Keyword(s):

Tyrosine Kinase ◽

Resistance Mechanisms ◽

Intratumoral Heterogeneity ◽

Kinase Inhibition ◽

Egfr Tyrosine Kinase ◽

Egfr Mutant

Antiproliferative effects of EGFR tyrosine kinase inhibition and radiation-induced genotoxic injury are attenuated by adhesion to fibronectin

Radiotherapy and Oncology ◽

10.1016/j.radonc.2006.07.028 ◽

2006 ◽

Vol 80 (2) ◽

pp. 178-184 ◽

Cited By ~ 36

Author(s):

Iris Eke ◽

Veit Sandfort ◽

Antje Mischkus ◽

Michael Baumann ◽

Nils Cordes

Keyword(s):

Tyrosine Kinase ◽

Kinase Inhibition ◽

Antiproliferative Effects ◽

Egfr Tyrosine Kinase ◽

Radiation Induced

HER Kinase Axis Receptor Dimer Partner Switching Occurs in Response to EGFR Tyrosine Kinase Inhibition despite Failure to Block Cellular Proliferation

Cancer Research ◽

10.1158/0008-5472.can-09-3326 ◽

2010 ◽

Vol 70 (5) ◽

pp. 1989-1999 ◽

Cited By ~ 52

Author(s):

Anjali Jain ◽

Elicia Penuel ◽

Sheldon Mink ◽

Joanna Schmidt ◽

Amanda Hodge ◽

...

Keyword(s):

Tyrosine Kinase ◽

Cellular Proliferation ◽

Kinase Inhibition ◽

Egfr Tyrosine Kinase ◽

Receptor Dimer

Maintained sensitivity to EGFR tyrosine kinase inhibitors (TKIs) in EGFR-mutant lung cancers that recur after adjuvant TKI.

Journal of Clinical Oncology ◽

10.1200/jco.2011.29.15_suppl.7029 ◽

2011 ◽

Vol 29 (15_suppl) ◽

pp. 7029-7029

Author(s):

G. R. Oxnard ◽

Y. Y. Janjigian ◽

M. E. Arcila ◽

M. G. Kris ◽

M. Ladanyi ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Lung Cancers ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Egfr Mutant

Blockade of AXL activation overcomes acquired resistance to EGFR tyrosine kinase inhibition in non-small cell lung cancer

Translational Cancer Research ◽

10.21037/tcr.2019.09.61 ◽

2019 ◽

Vol 8 (6) ◽

pp. 2425-2438 ◽

Cited By ~ 1

Author(s):

Feng Wang ◽

Xuewen Liu ◽

Boris A. Bartholdy ◽

Haiying Cheng ◽

Balazs Halmos

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Acquired Resistance ◽

Small Cell ◽

Small Cell Lung ◽

Kinase Inhibition ◽

Response to Dual Crizotinib and Osimertinib Treatment in a Lung Cancer Patient with MET Amplification Detected by Liquid Biopsy Who Acquired Secondary Resistance to EGFR Tyrosine Kinase Inhibition

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2018.04.007 ◽

2018 ◽

Vol 13 (9) ◽

pp. e169-e172 ◽

Cited By ~ 13

Author(s):

Lei Deng ◽

Lesli A. Kiedrowski ◽

Elizabeth Ravera ◽

Haiying Cheng ◽

Balazs Halmos

Keyword(s):

Lung Cancer ◽

Cancer Patient ◽

Tyrosine Kinase ◽

Liquid Biopsy ◽

Lung Cancer Patient ◽

Kinase Inhibition ◽

Secondary Resistance ◽

Egfr Tyrosine Kinase ◽

Met Amplification

EGFR tyrosine kinase inhibition induces autophagy in cancer cells

Cancer Biology & Therapy ◽

10.4161/cbt.22002 ◽

2012 ◽

Vol 13 (14) ◽

pp. 1417-1424 ◽

Cited By ~ 62

Author(s):

Christopher Fung ◽

Xing Chen ◽

Jennifer R. Grandis ◽

Umamaheswar Duvvuri

Keyword(s):

Tyrosine Kinase ◽

Cancer Cells ◽

Kinase Inhibition ◽

EGFR tyrosine kinase inhibition radiosensitizes and induces apoptosis in malignant glioma and childhood ependymoma xenografts

International Journal of Cancer ◽

10.1002/ijc.23488 ◽

2008 ◽

Vol 123 (1) ◽

pp. 209-216 ◽

Cited By ~ 40

Author(s):

Birgit Geoerger ◽

Nathalie Gaspar ◽

Paule Opolon ◽

Jackie Morizet ◽

Pauline Devanz ◽

...

Keyword(s):

Tyrosine Kinase ◽

Malignant Glioma ◽

Kinase Inhibition ◽

Strategies to Overcome Bypass Mechanisms Mediating Clinical Resistance to EGFR Tyrosine Kinase Inhibition in Lung Cancer

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-16-0105 ◽

2017 ◽

Vol 16 (2) ◽

pp. 265-272 ◽

Cited By ~ 17

Author(s):

Hatim Husain ◽

Michael Scur ◽

Ayesha Murtuza ◽

Nam Bui ◽

Brian Woodward ◽

...

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Kinase Inhibition ◽

Egfr Tyrosine Kinase ◽

Clinical Resistance