scholarly journals Epidermal Growth Factor Receptor, C-kit, and Her2/neu Immunostaining in Advanced or Recurrent Thymic Epithelial Neoplasms Staged According to the 2004 World Health Organization in Patients Treated with Octreotide and Prednisone: An Eastern Cooperative Oncology Group Study

2010 ◽  
Vol 5 (6) ◽  
pp. 885-892 ◽  
Author(s):  
Seena C. Aisner ◽  
Suzanne Dahlberg ◽  
Meera R. Hameed ◽  
David S. Ettinger ◽  
Joan H. Schiller ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Eastern Cooperative Oncology Group ◽  
Growth Factor Receptor ◽  
World Health ◽  
Oncology Group ◽  
Oncology Group Study ◽  
Epidermal Growth ◽  
Epithelial Neoplasms ◽  
Health Organization

Bronchioloalveolar Carcinoma: A Review of Current Concepts and Evolving Issues

2007 ◽  
Vol 131 (7) ◽  
pp. 1027-1032 ◽  
Author(s):  
Samuel A. Yousem ◽  
Mary Beth Beasley
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Data Sources ◽  
World Health ◽  
Bronchioloalveolar Carcinoma ◽  
Clinical Aspects ◽  
Epidermal Growth ◽  
The Subject ◽  
Health Organization ◽  
Multifocal Disease

Abstract Context.—The concept of bronchioloalveolar carcinoma underwent considerable refinement between the publications of the 1981 and 1999 World Health Organization classifications of lung tumors. Both pathologic and clinical aspects of this carcinoma are the subject of considerable interest. Objective.—To review and summarize the evolution of the current concept of bronchioloalveolar carcinoma and evolving issues that are under further investigation. Data Sources.—Pertinent peer-reviewed literature emphasizing historical classification and evolution as well as current and evolving concepts. Conclusions.—Small, solitary, nonmucinous bronchioloalveolar carcinomas are associated with a markedly better prognosis compared with conventional invasive adenocarcinomas. Such tumors may be cured by surgical resection and may be more responsive to epidermal growth factor receptor–targeted therapy. The prognosis and staging of multifocal disease remain unresolved, as does the question of whether a small amount of invasion adversely affects prognosis. Mucinous bronchioloalveolar carcinoma appears to be a markedly different entity than the nonmucinous subtype.

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