Effect of Polymyxin B-Immobilized Fiber Hemoperfusion on Serum High Mobility Group Box-1 Protein Levels and Oxidative Stress in Patients With Acute Respiratory Distress Syndrome

ASAIO Journal ◽  
2009 ◽  
Vol 55 (4) ◽  
pp. 395-399 ◽  
Author(s):  
Tsukasa Nakamura ◽  
Nobuharu Fujiwara ◽  
Eiichi Sato ◽  
Yasuhiro Kawagoe ◽  
Yoshihiko Ueda ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
High Mobility ◽  
Polymyxin B ◽  
High Mobility Group ◽  
Protein Levels ◽  
And Oxidative Stress

scholarly journals Acupoint Catgut Embedding Improves the Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Dan Li ◽  
Tian Sun ◽  
Laiting Chi ◽  
Dengming Zhao ◽  
Wenzhi Li
Keyword(s):  
Oxidative Stress ◽  
Acute Respiratory Distress Syndrome ◽  
Lung Injury ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Normal Saline ◽  
Distress Syndrome ◽  
Sod Activity ◽  
Protein Levels ◽  
And Oxidative Stress

Background. This study investigated the potential therapeutic effects of acupoint catgut embedding (ACE) at ST36 and BL13 on lipopolysaccharide- (LPS-) induced acute respiratory distress syndrome (ARDS) in rats. Materials and Methods. Male Sprague-Dawley rats were randomized into the normal saline (NS group with a sham procedure), lipopolysaccharide (LPS group with a sham procedure), and LPS plus ACE (LPS+ACE with ACE at bilateral BL13 and ST36 acupoints one day before LPS injection) groups. After intratracheal instillation of normal saline or LPS (0.5 mg/kg), all rats were subjected to mechanical ventilation for 4 h. Their blood gas was analyzed before and after lung injury, and their lung pressure-volumes were measured longitudinally. The levels of TNF-α, IL-6, IL-10, and phosphatidylcholine (PC) and total proteins (TP) in bronchial alveolar lavage fluid (BALF) were assessed. Their wet to dry lung weight ratios, histology, myeloperoxidase (MPO), superoxide dismutase (SOD) activity, and malondialdehyde (MDA) levels were measured. Their lung aquaporin 1 (AQP1) and Occludin protein levels were analyzed. Results. LPS administration significantly decreased the ratios of PaO2/FiO2 and pressure-volumes and induced lung inflammation and injury by increased concentrations of TNF-α, IL-6, IL-10, and TP in BALF and MPO and MDA in the lung but decreased PC in BALF and SOD activity in the lungs. LPS also reduced AQP1 and Occludin protein levels in the lung of rats. In contrast, ACE significantly mitigated the LPS-induced lung injury, inflammation, and oxidative stress and preserved the AQP1 and Occludin contents in the lung of rats. Conclusions. ACE significantly improved respiratory function by mitigating inflammation and oxidative stress and preserving AQP1 and Occludin expression in the lung in a rat model of LPS-induced ARDS.

scholarly journals Bibliometric Analysis of Literature on Acute Respiratory Distress Syndrome Treatments Published Between 2000 and 2019

2020 ◽  
Author(s):  
Zong-Yu Wang ◽  
Zhi-Chao Zhou ◽  
Jie Zheng ◽  
Zhu-Kai Cong ◽  
Xi Zhu
Keyword(s):  
Oxidative Stress ◽  
Acute Respiratory Distress Syndrome ◽  
Extracorporeal Membrane Oxygenation ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Meta Analysis ◽  
Research Interest ◽  
Membrane Oxygenation ◽  
And Oxidative Stress

Abstract Background: Acute respiratory distress syndrome (ARDS) is a common and extensively researched condition, and treatment modalities are continuously being developed and improved. Although the literature on ARDS treatment is vast, there have not been any bibliographic analyses examining trends in this area. We aimed to systematically evaluate the literature on ARDS treatments published between 2000 and 2019, from the perspective of bibliometrics.Methods: Literature retrieval was performed in PubMed and in the Web of Science Core Collection, and analyzed for publication and temporal trends. CiteSpace was used to perform co-occurrence analysis for institutions, and reference co-citation analysis for research topics. Burst keyword detection was used to predict future areas of research interest in the field.Results: A total of 13,933 articles were retrieved. The journal Critical Care Medicine published the largest number of articles (956, 6.86%). The University of Toronto was affiliated with the most publications (574, 4.28%) and had the highest degree of betweenness centrality, indicating extensive inter-institution collaboration. The papers on ARDS treatment published between 2000 and 2019 were grouped into 10 major clusters, 3 of which indicated recent activity (“acute lung injury,” “long-term outcome” and “extracorporeal membrane oxygenation”). Fifteen burst keywords/terms were identified, including extracorporeal membrane oxygenation, meta-analysis and oxidative stress.Conclusions: On the basis of the literature published in the preceding 20 years, the exploration of ARDS treatment is an ongoing concern. Extracorporeal membrane oxygenation was an active focus of research in this field. It and oxidative stress are likely to become major topics of research interest in the near future. Meta-analysis will be a popular method in analyzing the efficacy of ARDS treatments.

scholarly journals Bibliometric Analysis of Literature on Acute Respiratory Distress Syndrome Treatments Published Between 2000 and 2019

2020 ◽  
Author(s):  
Zong-Yu Wang ◽  
Zhi-Chao Zhou ◽  
Jie Zheng ◽  
Zhu-Kai Cong ◽  
Xi Zhu
Keyword(s):  
Oxidative Stress ◽  
Acute Respiratory Distress Syndrome ◽  
Extracorporeal Membrane Oxygenation ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Meta Analysis ◽  
Research Interest ◽  
Membrane Oxygenation ◽  
And Oxidative Stress

Abstract Background: Acute respiratory distress syndrome (ARDS) is a common and extensively researched condition, and treatment modalities are continuously being developed and improved. Although the literature on ARDS treatment is vast, there have not been any bibliographic analyses examining trends in this area. We aimed to systematically evaluate the literature on ARDS treatments published between 2000 and 2019, from the perspective of bibliometrics.Methods: Literature retrieval was performed in PubMed and in the Web of Science Core Collection, and analyzed for publication and temporal trends. CiteSpace was used to perform co-occurrence analysis for institutions, and reference co-citation analysis for research topics. Burst keyword detection was used to predict future areas of research interest in the field.Results: A total of 13,933 articles were retrieved. The journal Critical Care Medicine published the largest number of articles (956, 6.86%). The University of Toronto was affiliated with the most publications (574, 4.28%) and had the highest degree of betweenness centrality, indicating extensive inter-institution collaboration. The papers on ARDS treatment published between 2000 and 2019 were grouped into 10 major clusters, 3 of which indicated recent activity (“acute lung injury,” “long-term outcome” and “extracorporeal membrane oxygenation”). Fifteen burst keywords/terms were identified, including extracorporeal membrane oxygenation, meta-analysis and oxidative stress.Conclusions: On the basis of the literature published in the preceding 20 years, the exploration of ARDS treatment is an ongoing concern. Extracorporeal membrane oxygenation was an active focus of research in this field. It and oxidative stress are likely to become major topics of research interest in the near future. Meta-analysis will be a popular method in analyzing the efficacy of ARDS treatments.

scholarly journals Acute respiratory distress syndrome caused by carbon monoxide poisoning and inhalation injury recovered after extracorporeal membrane oxygenation along with direct hemoperfusion with polymyxin B-immobilized fiber column: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Ji Hoon Jang ◽  
Hang Jea Jang ◽  
Hyun-Kuk Kim ◽  
Jin Han Park ◽  
Hyo-Jung Kim ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Carbon Monoxide Poisoning ◽  
Polymyxin B ◽  
Inhalation Injury ◽  
Cytokine Storm ◽  
Direct Hemoperfusion

Abstract Background Inhalation injury from smoke or chemical products and carbon monoxide poisoning are major causes of death in burn patients from fire accidents. Respiratory tract injuries from inhalation injury and carbon monoxide poisoning can lead to acute respiratory distress syndrome and cytokine storm syndrome. In the case of acute respiratory failure needing mechanical ventilation accompanied by cytokine storm, mortality is high and immediate adequate treatment at the emergency department is very important. Case presentation This report describes a case of acute respiratory distress syndrome and cytokine storm followed by carbon monoxide poisoning in a 34-year-old Korean male patient who was in a house fire, and was successfully treated by extracorporeal membrane oxygenation and direct hemoperfusion with polymyxin B-immobilized fiber column at emergency department. Conclusions To prevent mortality in acute respiratory distress syndrome with cytokine storm from inhalation injury and to promote a better prognosis, we suggest that early implication of extracorporeal membranous oxygenation along with direct hemoperfusion with polymyxin B-immobilized fiber column even at the emergency department should be considered.

scholarly journals Alveolar CCN1 is associated with mechanical stretch and acute respiratory distress syndrome severity

2020 ◽  
Vol 319 (5) ◽  
pp. L825-L832
Author(s):  
Eric D. Morrell ◽  
Serge Grazioli ◽  
Chi Hung ◽  
Osamu Kajikawa ◽  
Susanna Kosamo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Acute Respiratory Distress Syndrome ◽  
Lung Injury ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Mechanical Stretch ◽  
Mechanically Ventilated ◽  
Alveolar Epithelial ◽  
Protein Levels

The cellular communication network factor 1 (CCN1) is a matricellular protein that can modulate multiple tissue responses, including inflammation and repair. We have previously shown that adenoviral overexpression of Ccn1 is sufficient to cause acute lung injury in mice. We hypothesized that CCN1 is present in the airspaces of lungs during the acute phase of lung injury, and higher concentrations are associated with acute respiratory distress syndrome (ARDS) severity. We tested this hypothesis by measuring 1) CCN1 in bronchoalveolar lavage fluid (BALF) and lung homogenates from mice subjected to ventilation-induced lung injury (VILI), 2) Ccn1 gene expression and protein levels in MLE-12 cells (alveolar epithelial cell line) subjected to mechanical stretch, and 3) CCN1 in BALF from mechanically ventilated humans with and without ARDS. BALF CCN1 concentrations and whole lung CCN1 protein levels were significantly increased in mice with VILI ( n = 6) versus noninjured controls ( n = 6). Ccn1 gene expression and CCN1 protein levels were increased in MLE-12 cells cultured under stretch conditions. Subjects with ARDS ( n = 77) had higher BALF CCN1 levels compared with mechanically ventilated subjects without ARDS ( n = 45) ( P < 0.05). In subjects with ARDS, BALF CCN1 concentrations were associated with higher total protein, sRAGE, and worse [Formula: see text]/[Formula: see text] ratios (all P < 0.05). CCN1 is present in the lungs of mice and humans during the acute inflammatory phase of lung injury, and concentrations are higher in patients with increased markers of severity. Alveolar epithelial cells may be an important source of CCN1 under mechanical stretch conditions.

scholarly journals Biomarkers of acute respiratory distress syndrome in adults hospitalised for severe SARS-CoV-2 infection in Tenerife Island, Spain

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Juan Marco Figueira Gonçalves ◽  
José María Hernández Pérez ◽  
Marco Acosta Sorensen ◽  
Aurelio Luis Wangüemert Pérez ◽  
Elena Martín Ruiz de la Rosa ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Significant Negative Correlation ◽  
Protein Levels ◽  
Reactive Protein ◽  
Infected Adult ◽  
Tenerife Island ◽  
Fraction Of Inspired Oxygen

Abstract Objective The dramatic spread of SARS-CoV-2 infections calls for reliable, inexpensive tools to quickly identify patients with a poor prognosis. In this study, acute respiratory distress syndrome (ARDS) was assessed within 72 h after admission of each of 153 consecutive, SARS-CoV-2 infected, adult patients to either of two hospitals in Tenerife, Spain, using suitable routine laboratory tests for lymphocyte counts, as well as ferritin, lactate dehydrogenase (LDH), and C-reactive protein levels. Results were correlated with the patients’ respiratory function, defined through their pulse oximetric saturation/fraction of inspired oxygen (SpO2/FiO2) ratio. Results Within 72 h from admission, criteria matched ARDS (SpO2/FiO2 < 235) in 13.1% of cases. We found a significant, negative correlation between SpO2/FiO2 ratios and d-dimer, ferritin, and LDH levels (− 0.31, − 0.32, and − 0.41; p = 0.004, 0.004, and < 0.0001, respectively). In patients with ARDS, the mean LDH was 373 U/L (CI95%: 300.6–445.3), but only 298 U/L (CI95%: 274.7–323.1) when they did not develop the syndrome (p = 0.015). None of the additionally evaluated biomarkers correlated with the SpO2/FiO2 ratios. Serum LDH levels in patients hospitalised for COVID-19 correlate with ARDS, as defined by their SpO2/FiO2 ratio, and might help to predict said complication.

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