Does heart failure etiology, New York Heart Association class, or ejection fraction affect the ability of clopidogrel to inhibit heightened platelet activity?

2007 ◽  
Vol 18 (2) ◽  
pp. 91-96 ◽  
Author(s):  
Alex I Malinin ◽  
Benjamin R Oshrine ◽  
David C Sane ◽  
Christopher M OʼConnor ◽  
Victor L Serebruany
Keyword(s):  
Heart Failure ◽  
New York ◽  
Ejection Fraction ◽  
Heart Association ◽  
York Heart Association Class ◽  
Platelet Activity ◽  
Association Class ◽  
New York Heart Association

scholarly journals Correlation of Coagulation Pathway Parameters with BNP, Ejection Fraction and NYHA Class in Heart Failure

2016 ◽  
Vol 8 ◽  
Author(s):  
Nandini Nair ◽  
Enrique Gongora
Keyword(s):  
Heart Failure ◽  
New York ◽  
Ejection Fraction ◽  
Rank Order ◽  
Heart Association ◽  
Functional Class ◽  
York Heart Association Class ◽  
Association Class ◽  
New York Heart Association ◽  
Coagulation Pathway

<p>Abstract</p><p> </p><p>Background</p><p>The upregulation of inflammation and coagulation in addition to the sympathetic nervous system is known and reported in congestive heart failure. This study was undertaken to assess the correlations of the changes in coagulation parameters with functional class, ejection fraction and brain natriuretic peptide levels.</p><p> </p><p>Methods</p><p>A small prospective study was conducted in dilated cardiomyopathy (DCM) patients.</p><p>The protocol was approved by the Hospital IRB ( Scott and White Memorial, Temple, TX 76508). Statistical analysis was conducted using the online Vassar stats system . Spearman’s rank order correlation was derived for all the correlations mentioned in this paper.</p><p> </p><p>Results</p><p>PT, PTT, INR and d-dimer levels were significantly different in the two groups and correlated positively and significantly with BNP and New York Heart Association class . Statistically significant negative correlation was noted with ejection fraction. fibrinogen levels did not correlate significantly with BNP, New York Heart Association class or ejection fraction.</p><p> </p><p>Conclusions</p><p>Coagulation pathway parameters correlate significantly with BNP, functional class and ejection fraction in this study. The study is limited by its size and the fact that only dilated non- ischemic cardiomyopathy patients were included.   Larger studies are required to further understand the complex interactions of biochemical pathways noted in heart failure.</p><p> </p>

scholarly journals New York Heart Association class is strongly associated with mortality beyond heart failure in symptomatic women

2020 ◽  
Author(s):  
Klaske R Siegersma ◽  
Floor Groepenhoff ◽  
N Charlotte Onland-Moret ◽  
Igor I Tulevski ◽  
Leonard Hofstra ◽  
...  
Keyword(s):  
Heart Failure ◽  
New York ◽  
Heart Association ◽  
York Heart Association Class ◽  
Association Class ◽  
New York Heart Association

scholarly journals Impact of Left Ventricular Function and Heart Failure Symptoms on Outcomes Post Ablation of Atrial Fibrillation in Heart Failure

2020 ◽  
Vol 13 (10) ◽  
Author(s):  
Christian Sohns ◽  
Konstantin Zintl ◽  
Yan Zhao ◽  
Lilas Dagher ◽  
Dietrich Andresen ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
New York ◽  
Ventricular Dysfunction ◽  
Heart Association ◽  
Left Ventricular ◽  
Pharmacological Therapy ◽  
York Heart Association Class ◽  
Association Class ◽  
New York Heart Association

Background: Recent data demonstrate promising effects on left ventricular dysfunction and left ventricular ejection fraction (LVEF) improvement following ablation for atrial fibrillation (AF) in patients with heart failure. We sought to study the relationship between LVEF, New York Heart Association class on presentation, and the end points of mortality and heart failure admissions in the CASTLE-AF study (Catheter Ablation for Atrial Fibrillation With Heart Failure) population. Furthermore, predictors for LVEF improvement were examined. Methods: The CASTLE-AF patients with coexisting heart failure and AF (n=363) were randomized in a multicenter prospective controlled fashion to ablation (n=179) versus pharmacological therapy (n=184). Left ventricular function and New York Heart Association class were assessed at baseline (after randomization) and at each follow-up visit. Results: In the ablation arm, a significantly higher number of patients experienced an improvement in their LVEF to >35% at the end of the study (odds ratio, 2.17; P <0.001). Compared with the pharmacological therapy arm, both ablation patient groups with severe (<20%) or moderate/severe (≥20% and <35%) baseline LVEF had a significantly lower number of composite end points (hazard ratio [HR], 0.60; P =0.006), all-cause mortality (HR, 0.54; P =0.019), and cardiovascular hospitalizations (HR, 0.66; P =0.017). In the ablation group, New York Heart Association I/II patients at the time of treatment had the strongest improvement in clinical outcomes (primary end point: HR, 0.43; P <0.001; mortality: HR, 0.30; P =0.001). Conclusions: Compared with pharmacological treatment, AF ablation was associated with a significant improvement in LVEF, independent from the severity of left ventricular dysfunction. AF ablation should be performed at early stages of the patient’s heart failure symptoms.

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