Significance of Granulomatous Inflammation Found on Endoscopic Biopsies or Surgical Resections on the Severity of Crohn’s Disease

2013 ◽  
Vol 47 (10) ◽  
pp. 894 ◽  
Author(s):  
Manasa Kanneganti ◽  
Bijan Dehghani ◽  
James Steinberg ◽  
Sandra Cerda ◽  
Denis Rybin ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Granulomatous Inflammation ◽  
Endoscopic Biopsies

scholarly journals Crohn's Disease Defined in Three Elderly Disters

2005 ◽  
Vol 19 (4) ◽  
pp. 251-252
Author(s):  
Hugh J Freeman
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Environmental Factor ◽  
Present Report ◽  
Granulomatous Inflammation ◽  
Disease Clustering ◽  
Endoscopic Biopsies ◽  
Unusual Occurrence ◽  
Shared Environmental Factor

Three elderly sisters presented with symptomatic Crohn's disease. All had ileocolic involvement, and granulomatous inflammation was documented in endoscopic biopsies or surgically resected intestinal specimens. The present report documents the unusual occurrence of very late phenotypical expression of familial ileocolic Crohn's disease. The observations presented here reflect a possible gene-based predisposition to Crohn's disease or, alternatively, disease clustering related to a commonly shared environmental factor.

CROHN’S DISEASE IN CHILDREN: THE CURRENT STATE OF THE PROBLEM

2021 ◽  
Vol 100 (6) ◽  
pp. 78-85
Author(s):  
A.S. Bekin ◽  
◽  
E.Yu. Dyakonova ◽  
A.N. Surkov ◽  
A.P. Fisenko ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Surgical Treatment ◽  
Crohn's Disease ◽  
Granulomatous Inflammation ◽  
Unknown Etiology ◽  
Systemic Complications ◽  
Current State ◽  
Conservative And Surgical Treatment ◽  
Scientific Ideas ◽  
Local And Systemic Complications

Crohn's disease (CD) is chronic recurrent bowel disease of unknown etiology, characterized by segmental transmural granulomatous inflammation, mainly with the development of local and systemic complications. Despite the active development of conservative therapy methods, the number of drug-resistant forms of CD and complications of the disease requiring surgical treatment continues to increase. The article reflects modern scientific ideas about the methods of diagnosis, conservative and surgical treatment of CD in children.

scholarly journals Unsuccessful Treatment of Cheilitis Granulomatosa with Oral Methotrexate

2019 ◽  
Vol 11 (3) ◽  
pp. 249-255 ◽  
Author(s):  
Thanapon Sutharaphan ◽  
Kumutnart Chanprapaph ◽  
Vasanop Vachiramon
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Case Reports ◽  
Corticosteroid Injection ◽  
Granulomatous Inflammation ◽  
Spontaneous Remission ◽  
Expert Opinions ◽  
Cheilitis Granulomatosa ◽  
Unsuccessful Treatment ◽  
Intralesional Corticosteroid

Cheilitis granulomatosa (CG) is a rare idiopathic condition with painless lip swelling, characterized by non-necrotizing granulomatous inflammation in the absence of other identifiable causes such as Crohn’s disease, sarcoidosis, foreign body reaction, or infection. CG may precede the presentation of Crohn’s disease after long-term follow-up. Spontaneous remission of CG rarely occurs. To date, given the rarity of CG, there is no gold standard treatment. Recommended treatments are supported by small studies, case reports/series, and expert opinions. Glucocorticoids are the first-line therapy in the acute stages of the disease; however, recurrence commonly occurs. Previously, methotrexate (MTX) showed a beneficial effect on orofacial swelling in a case of CG accompanied by Crohn’s disease. We present a patient with CG without Crohn’s disease. He was treated with oral MTX in combination with intralesional corticosteroid injection on one side of the lip. The injected side showed improvement, while lip swelling on the noninjected area remained unchanged after 3 months of treatment. Therefore, CG is refractory to treatment with MTX from our experience. Further studies regarding the optimum dosage of MTX is needed.

A case report of a patient with isolated Crohn’s disease of the stomach

2021 ◽  
Vol 19 (3) ◽  
pp. 95-101
Author(s):  
E.A. Trush ◽  
◽  
A.I. Ulyanin ◽  
A.V. Korolev ◽  
L.N. Androsova ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Clinical Symptoms ◽  
Granulomatous Inflammation ◽  
Endoscopic Finding ◽  
Disease Course ◽  
Morphological Examination ◽  
Gastric Biopsies ◽  
Upper Gastrointestinal

Crohn’s disease of the esophagus, stomach or duodenum is extremely rare and characterized by an aggressive disease course with a poor prognosis. Clinical symptoms of the upper gastrointestinal tract lesion are nonspecific, therefore esophagogastroduodenoscopy with biopsy is necessary for the differential diagnosis. Crohn’s disease of the stomach is characterized by a specific endoscopic finding – bamboo-joint-like appearance of gastric folds. Granulomatous inflammation in morphological examination of gastric biopsies in patients with Crohn’s disease is rare, therefore endoscopic finding is more pathognomonic. This article presents a clinical case of a patient with isolated Crohn’s disease of stomach, differential diagnosis and treatment approaches of the disease. Key words: Crohn’s disease, Crohn’s disease with lesions of the stomach, gastroprotective agents, proton pump inhibitors, endoscopic sonography

scholarly journals Aphthous stomatitis as the debut of Crohn’s disease

2020 ◽  
pp. 97-100
Author(s):  
O. V. Gaus ◽  
V. A. Akhmedov ◽  
A. S. Korshunov
Keyword(s):  
Crohn’S Disease ◽  
Gastrointestinal Tract ◽  
Crohn's Disease ◽  
Granulomatous Inflammation ◽  
Aphthous Stomatitis ◽  
Systemic Complications ◽  
Immune Mediated ◽  
Transmural Inflammation ◽  
Retromolar Region

Crohn’s disease is an immune-mediated disease characterized by non-specific granulomatous transmural inflammation with segmental damage to any part of the gastrointestinal tract with the formation of extraintestinal and systemic complications. Clinical observation of patient I., 23 years old, a student who was sent for consultation to a gastroenterologist in the direction of a dentist, is presented. Active examination of the gastrointestinal tract during the inspection did not show any complaints. He considers himself ill for 6 months, when he first complained of pain in the neck, sore throat, and body temperature rise to 37.4–37.5 °C, mostly in the evening. Were treated by an otolaryngologist and a dentist without significant effect. In this connection, a biopsy of the ulcerative defect of the left retromolar region was performed, revealing noncaseating granulomatous inflammation. A follow-up examination by a gastroenterologist with colonoscopy and biopsy made it possible to establish Crohn’s disease as the true cause of aphthous stomatitis.

scholarly journals SUBSTANTIATION OF DIAGNOSIS AND TREATMENT OF CHRONIC RECURRENT APHTHOUS STOMATITIS IN CROHN’S DISEASE

2020 ◽  
Vol 73 (3) ◽  
pp. 512-516
Author(s):  
Oksana Y. Feleshtynska ◽  
Olena O. Dyadyk
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Oral Mucosa ◽  
Morphological Study ◽  
Comparison Group ◽  
Granulomatous Inflammation ◽  
Main Group ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Diagnosis And Treatment

The aim: To substantiate the diagnosis and treatment of chronic recurrent aphthous stomatitis in Crohn’s disease. Materials and methods: The analysis of diagnostic and treatment of 52 patients with chronic recurrent aphthous stomatitis in Crohn’s disease (main group), mean age 31.8 + 2.3 was performed. The comparison group consisted of 50 patients with chronic recurrent aphthous stomatitis not associated with Crohn’s disease (mean age 34.7 + 1.8). Patients in both groups were studied for clinical manifestations, morphological and immunohistochemical studies the aphthae on the oral mucosa were performed. Results: An objective evaluation of the oral mucosa showed that the aphthae on the oral mucosa in patients of both groups did not differ visually. In the morphological study, the patients in the main group had granulomatous inflammation of the oral mucosa, characteristic of Crohn’s disease, while the patients in the comparison group had fibrinous inflammation. Immunohistochemical study of the cell infiltrate phenotype in the area of the lesion revealed that the patients in the main group there prevailed CD68+macrophages, the appearance of both intraepithelial and cell infiltrates of T-lymphocyte suppressors, which is characteristic of Crohn’s disease. Conclusions: Diagnosis of chronic recurrent aphthous stomatitis in Crohn’s disease is based on biopsy of the aphthae on the oral mucosa and their morphological examination, the results of which confirm the presence of granulomatous inflammation, with a large number of macrophages, the presence of T-lymphocytes, characteristic of Crohn’s disease, while recurrent aphthous stomatitis of another genesis morphologically detect fibrinous inflammation. The choice of therapeutic tactics for chronic recurrent aphthous stomatitis depends on the results of the morphological study. When granulomatous inflammation is detected in patients with chronic recurrent aphthous stomatitis, which is characteristic of Crohn’s disease, in addition to topical treatment of the oral mucosa, specific therapy with mesalazine drugs is prescribed.

The value of endoscopic biopsies in the assessment of Crohn's disease

1995 ◽  
Vol 108 (4) ◽  
pp. A918
Author(s):  
K. Smedh ◽  
G Olaison ◽  
L Franzén ◽  
R Sjödahl
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Endoscopic Biopsies

scholarly journals Granulomatous vulvitis and Gullain-Barre syndrome in pediatric Crohn’s disease: a case report

2021 ◽  
Vol 8 (6) ◽  
pp. 1121
Author(s):  
Pujitha Bandla ◽  
Bhakti Sarangi ◽  
Guruprasad H. Shankar ◽  
Varsha Sharma
Keyword(s):  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Case Report ◽  
Crohn's Disease ◽  
Bowel Disease ◽  
Gastrointestinal Symptoms ◽  
Granulomatous Inflammation ◽  
Extraintestinal Manifestation ◽  
Gastrointestinal Manifestations ◽  
Inflammatory Bowel

Granulomatous vulvitis/cheilitis may occur rarely as an extraintestinal manifestation of Crohn’s disease (CD) and may precede the development of gastrointestinal symptoms. Guillain-Barre syndrome (GBS) is associated with a wide variety of illnesses including inflammatory bowel disease. Though the immunologic abnormalities in inflammatory bowel disease may encompass both granulomatous inflammation as well as autoimmune components, the combination of CD, GBS and granulomatous vulvitis/cheilitis in the same patient has not been described in literature. We hereby reported a 14 year old girl with granulomatous vulvitis/cheilitis for 4 years preceding the development of gastrointestinal manifestations of CD, who also had GBS during the course of hospitalization.

scholarly journals Sellar Inflammatory Mass with Inflammatory Bowel Disease

2010 ◽  
Vol 24 (1) ◽  
pp. 58-60 ◽  
Author(s):  
Hugh J Freeman ◽  
John Maguire
Keyword(s):  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Bowel Disease ◽  
Granulomatous Inflammation ◽  
Sellar Mass ◽  
Inflammatory Processes ◽  
Inflammatory Bowel ◽  
Term Management

Inflammatory bowel disease may be associated with different intracranial disorders. An inflammatory sellar mass is very rare but includes a variety of noninfectious causes including lymphocytic hypophysitis, granulomatous inflammation and Wegener’s granulomatosis. A 32-year-old man was diagnosed with an inflammatory sellar mass associated with an extensive colonic inflammatory process clinically characteristic of Crohn’s disease. The concurrent onset of these inflammatory disorders in distinctly separate sites may reflect their common embryological origin or represent an unusual form of metastatic Crohn’s disease. Further studies are needed to determine if less overt or focal sellar inflammatory processes occur in inflammatory bowel disease, particularly in Crohn’s disease because their occurrence may be critically relevant for long-term management.

Sign in / Sign up

Export Citation Format

Share Document