scholarly journals Unusual expansion of CD3+CD56+ natural killer T-like cells in peripheral blood after anticytokine treatment for graft-versus-host disease

Medicine ◽  
2018 ◽  
Vol 97 (38) ◽  
pp. e12429 ◽  
Author(s):  
Lixia Sheng ◽  
Huarui Fu ◽  
Yamin Tan ◽  
Yongxian Hu ◽  
Qitian Mu ◽  
...  
Keyword(s):  
Natural Killer ◽  
Graft Versus Host Disease ◽  
Peripheral Blood ◽  
Host Disease ◽  
Graft Versus Host ◽  
Natural Killer T

scholarly journals Low doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4–dependent mechanism

Blood ◽  
2011 ◽  
Vol 117 (11) ◽  
pp. 3220-3229 ◽  
Author(s):  
Dennis B. Leveson-Gower ◽  
Janelle A. Olson ◽  
Emanuela I. Sega ◽  
Richard H. Luong ◽  
Jeanette Baker ◽  
...  
Keyword(s):  
T Cells ◽  
Natural Killer ◽  
Graft Versus Host Disease ◽  
B Cell Lymphoma ◽  
Nkt Cells ◽  
Host Disease ◽  
Graft Versus Host ◽  
Gastrointestinal Pathology ◽  
Dependent Mechanism ◽  
Natural Killer T

Abstract CD4+ natural killer T (NKT) cells, along with CD4+CD25+ regulatory T cells (Tregs), are capable of controlling aberrant immune reactions. We explored the adoptive transfer of highly purified (> 95%) CD4+NKT cells in a murine model of allogeneic hematopoietic cell transplantation (HCT). NKT cells follow a migration and proliferation pattern similar to that of conventional T cells (Tcons), migrating initially to secondary lymphoid organs followed by infiltration of graft-versus-host disease (GVHD) target tissues. NKT cells persist for more than 100 days and do not cause significant morbidity or mortality. Doses of NKT cells as low as 1.0 × 104 cells suppress GVHD caused by 5.0 × 105 Tcons in an interleukin-4 (IL-4)–dependent mechanism. Protective doses of NKT cells minimally affect Tcon proliferation, but cause significant reductions in interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) production by donor Tcons and in skin, spleen, and gastrointestinal pathology. In addition, NKT cells do not impact the graft-versus-tumor (GVT) effect of Tcons against B-cell lymphoma-1 (BCL-1) tumors. These studies elucidate the biologic function of donor-type CD4+NKT cells in suppressing GVHD in an allogeneic transplantation setting, demonstrating clinical potential in reducing GVHD in HCT.

scholarly journals Graft-versus-host disease in recipients of grafts from natural killer T cell-deficient (J?281?/?) donors

Immunology ◽  
2006 ◽  
Vol 119 (3) ◽  
pp. 338-347 ◽  
Author(s):  
Cynthia A. Ellison ◽  
Masaru Taniguchi ◽  
Jacqie M. M. Fischer ◽  
Kent T. Hayglass ◽  
John G. Gartner
Keyword(s):  
T Cell ◽  
Natural Killer ◽  
Graft Versus Host Disease ◽  
Host Disease ◽  
Natural Killer T Cell ◽  
Graft Versus Host ◽  
Killer T Cell ◽  
Natural Killer T

scholarly journals Early posttransplantation donor-derived invariant natural killer T-cell recovery predicts the occurrence of acute graft-versus-host disease and overall survival

Blood ◽  
2012 ◽  
Vol 120 (10) ◽  
pp. 2144-2154 ◽  
Author(s):  
Marie-Thérèse Rubio ◽  
Lucia Moreira-Teixeira ◽  
Emmanuel Bachy ◽  
Marie Bouillié ◽  
Pierre Milpied ◽  
...  
Keyword(s):  
Overall Survival ◽  
Natural Killer ◽  
Graft Versus Host Disease ◽  
Cell Recovery ◽  
Inkt Cells ◽  
Hematopoietic Stem ◽  
Host Disease ◽  
Graft Versus Host ◽  
Invariant Natural Killer ◽  
Natural Killer T

Abstract Invariant natural killer T (iNKT) cells can experimentally dissociate GVL from graft-versus-host-disease (GVHD). Their role in human conventional allogeneic hematopoietic stem cell transplantation (HSCT) is unknown. Here, we analyzed the post-HSCT recovery of iNKT cells in 71 adult allografted patients. Results were compared with conventional T- and NK-cell recovery and correlated to the occurrence of GVHD, relapse, and survival. We observed that posttransplantation iNKT cells, likely of donor origin, recovered independently of T and NK cells in the first 90 days after HSCT and reached greater levels in recipient younger than 45 years (P = .003) and after a reduced-intensity conditioning regimen (P = .03). Low posttransplantation iNKT/T ratios (ie, < 10−3) were an independent factor associated with the occurrence of acute GVHD (aGVHD; P = .001). Inversely, reaching iNKT/T ratios > 10−3 before day 90 was associated with reduced nonrelapse mortality (P = .009) without increased risk of relapse and appeared as an independent predictive factor of an improved overall survival (P = .028). Furthermore, an iNKT/T ratio on day 15 > 0.58 × 10−3 was associated with a 94% risk reduction of aGVHD. These findings provide a proof of concept that early postallogeneic HSCT iNKT cell recovery can predict the occurrence of aGVHD and an improved overall survival.

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