scholarly journals Effects of age on the peak ratio of ophthalmic artery Doppler

Medicine ◽  
2020 ◽  
Vol 99 (52) ◽  
pp. e23694
Author(s):  
Xi-Yue Yang ◽  
Li-Fang Xu ◽  
Yuan Luo ◽  
Na Li ◽  
Jin-Pin Yang ◽  
...  
Keyword(s):  
Ophthalmic Artery ◽  
Peak Ratio

The smoothness index, but not the trough-to-peak ratio predicts changes in carotid artery wall thickness during antihypertensive treatment

2001 ◽  
Vol 19 (4) ◽  
pp. 703-711 ◽  
Author(s):  
Damiano Rizzoni ◽  
Maria Lorenza Muiesan ◽  
Massimo Salvetti ◽  
Maurizio Castellano ◽  
Giorgio Bettoni ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Wall Thickness ◽  
Antihypertensive Treatment ◽  
Peak Ratio ◽  
Artery Wall ◽  
Carotid Artery Wall ◽  
Smoothness Index

scholarly journals Exploring the effect of khat (Catha edulis) chewing on the pharmacokinetics of the antiplatelet drug clopidogrel in rats using the newly developed LC-MS/MS technique

2020 ◽  
Vol 18 (1) ◽  
pp. 681-690
Author(s):  
Hassan A. Alhazmi ◽  
Adnan A. Kadi ◽  
Mohamed W. Attwa ◽  
Waquar Ahsan ◽  
Manal Mohamed Elhassan Taha ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Active Metabolite ◽  
Dose Adjustment ◽  
Internal Standard ◽  
Cardiovascular Complications ◽  
Antiplatelet Drug ◽  
Peak Ratio ◽  
Cytochrome P450 Enzymes ◽  
Time Intervals ◽  
Addictive Substance

AbstractClopidogrel (CLOP) is widely used worldwide for cardiovascular complications. CLOP is highly metabolized in the liver to its active metabolite by cytochrome P450 enzymes. Studies have shown that khat, an addictive substance, is a powerful inhibitor of cytochrome P450 enzymes and can influence the metabolism of drugs that are concomitantly used. Therefore, this study was designed to evaluate the effects of khat on the pharmacokinetics of CLOP in rats. In this study, rats were administered either CLOP alone or CLOP combined with khat and their plasma were obtained at different time intervals and analyzed using the newly developed and validated liquid chromatography with tandem mass spectrometry (LC-MS/MS) method using foretinib (FTB) as the internal standard. The corresponding peak area of the analyte versus FTB was used for calculating the peak ratio. The validated LC-MS/MS method resulted in the separation of the well-defined quantifiable peaks of CLOP, FTB, and CLOP metabolite within 7 min. Results showed a significant influence of khat on the peak ratio of CLOP metabolite, which was found to be significantly decreased (P < 0.05) in comparison to CLOP alone, suggesting significant decrease in the conversion of CLOP to its active metabolite due to the inhibition of CYP450 enzymes by khat. Therefore, there might be a need for dose adjustment for regular khat chewers using CLOP.

scholarly journals Ophthalmic artery chemosurgery for retinoblastoma: an initial 3-year experience from two major institutes in Egypt

2020 ◽  
Vol 51 (1) ◽  
Author(s):  
Moustafa H Othman ◽  
Farouk Hassan ◽  
Hamdy M Ibrahim ◽  
Eman Aboelhamd Ahmed ◽  
George Yassa ◽  
...  
Keyword(s):  
Ophthalmic Artery

Contralateral catheterization of the ophthalmic artery to deliver intra-arterial chemotherapy in retinoblastoma

2021 ◽  
pp. 197140092110246
Author(s):  
Giancarlo Saal-Zapata ◽  
Rodolfo Rodríguez ◽  
Aaron Rodriguez-Calienes ◽  
Raúl Cordero
Keyword(s):  
Ophthalmic Artery ◽  
Internal Carotid ◽  
Pediatric Population ◽  
Anterior Communicating Artery ◽  
Chemotherapeutic Drugs ◽  
First Line ◽  
Chemotherapy Administration ◽  
Class D ◽  
Severity Of The Disease ◽  
Cure Rates

Retinoblastoma is the most frequent ocular malignancy in the pediatric population and intra-arterial chemotherapy has emerged as the first-line treatment of this entity with cure rates ranging from 33–100%, depending on the severity of the disease. We present the case of an advanced retinoblastoma in a pediatric patient who underwent intra-arterial chemotherapy through a contralateral route due to unsuccessful catheterization of the ophthalmic artery. The patient was diagnosed with a class D retinoblastoma which underwent the catheterization of the ophthalmic artery through the contralateral internal carotid and through the anterior communicating artery. In this case, intra-arterial chemotherapy administration was successfully delivered without complications. Contralateral routes for intra-arterial chemotherapy are safe and allow adequate penetration of the chemotherapeutic drugs in cases where a well-developed anterior communicating artery is present.

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