Reduction of blood pressure fluctuations by telmisartan molecule especially in combination with calcium channel antagonist

1.28 billion people suffer from hypertension, and its complications cause 10 million deaths each year. Effective antihypertensive therapy is therefore one of the priority tasks of health care. Achieving good BP control depends on many factors, but one of the primary ones is the use of maximally effective therapy in the simplest possible regimen. Amlodipine in combination with telmisartan in the single-pill combination, through its high smoothness index, makes it possible to achieve a satisfactory hypotensive effect lasting 24 h when taken once daily. This combination is also a good alternative for cardiovascularly burdened patients who cannot use angiotensin-converting enzyme inhibitors and for elderly patients, especially after stroke

Wrapping Deployment Simulation Analysis of Leaf-Inspired Membrane Structures

Deployable membrane structures have received wide attention in many engineering applications, such as the military, aerospace, and aviation. Their properties of light weight and high storage ratio meet the requirements for aerospace exactly. In this paper, the wrapping deployment of membrane structures inspired by leaves are simulation-analyzed for prospective improvement. Three leaf-inspired patterns are investigated and discussed from the corresponding paper-craft design principles and deployment process perspectives. The deployment performance evaluation system according to the factors effecting working performance including maximum stress, driving force, maximum strain energy, smoothness index, and maximum folding height is established based on the results of the simulation analysis. Then, a comparison between the three patterns is carried out based on the deployment performance evaluation system. Moreover, it is found that adding creases reduces the folded height but the development performance gets worse. There is a balance between the folding ratio and development performance when the additional creases are added. The results can provide useful suggestions for designing wrapping deployment structures.

Balancing assembly lines operating with heterogeneous workers under uncertainty in task processing times

PurposeThis paper considers the assembly line worker assignment and balancing problem of type-2 (ALWABP-2) with fuzzy task times. This problem is an extension of the (simple) SALBP-2 in which task times are worker-dependent and concurrently uncertain. Two criteria are simultaneously considered for minimization, namely, fuzzy cycle time and fuzzy smoothness index.Design/methodology/approachFirst, we show how fuzzy concepts can be used for managing uncertain task times. Then, we present a multiobjective genetic algorithm (MOGA) to solve the problem. MOGA is devoted to the search for Pareto-optimal solutions. For facilitating effective trade-off decision-making, two different MO approaches are implemented and tested within MOGA: a weighted-sum based approach and a Pareto-based approach.FindingsExperiments over a set of fuzzified test problems show the effect of these approaches on the performance of MOGA while verifying its efficiency in terms of both solution and time quality.Originality/valueTo the author’s knowledge, no previous published work in the literature has studied the biobjective assembly line worker assignment and balancing problem of type-2 (ALWABP-2) with fuzzy task times.

Robust Wake Rollup Modelling Using Dyes

This project report gives details on a modification of VAPTOR, a program that can predict the aerodynamic performance of aircrafts using a potential flow method with a relaxed wake model. In VAPTOR the wake is modelled using distributed vorticity elements (DVEs). DVEs can induce velocities at certain points used to relax the wake. A DVE has inbuilt singularity protections i.e. prevents the calculated velocity to approach infinity, but when two adjacent DVEs have a very low relative angle, these protections lead to an error in the calculation of the velocity at its shared midpoint during the relaxation process. In most cases these errors are negligible until a rotor is analysed during hover or vortex ring state. In these special cases the wake rollup is more intense leading to relatively small angles. The subsequent errors caused by the singularity protections cannot be ignored since they cause the solutions to be erratic and not smooth. It also causes the wake DVEs to deform disproportionally which is a visual indication of the errors. The modification uses a method that involves splitting the DVE in order to eliminate the errors when calculating the velocity at the junction of two adjacent DVEs. The splitting is temporary and only applied during the calculation of the velocity at the junction. The algorithm for the splitting of the DVE and its implementation into MATLAB is provided in this report. The implementation is tested by ensuring that all conditions are kept the same except when splitting is enabled or disabled. A number of test runs were conducted, and an index called the Smoothness Index was created in order to quantify the improvements of the DVE splitting method. The results shown are promising as the solution with splitting enabled is twice as smooth as when the splitting is disabled. There is also a noticeable improvement during visual comparison of the wake diagrams when splitting is enabled and disabled. The results combined with the fact that the extra computation required to execute the DVE splitting method is negligible, the author recommends it be enabled in all cases. Having said that, the end user has full control whether he or she would like to use it or not. They can also change the parameters of splitting to suit their needs.

Robust Wake Rollup Modelling Using Dyes

This project report gives details on a modification of VAPTOR, a program that can predict the aerodynamic performance of aircrafts using a potential flow method with a relaxed wake model. In VAPTOR the wake is modelled using distributed vorticity elements (DVEs). DVEs can induce velocities at certain points used to relax the wake. A DVE has inbuilt singularity protections i.e. prevents the calculated velocity to approach infinity, but when two adjacent DVEs have a very low relative angle, these protections lead to an error in the calculation of the velocity at its shared midpoint during the relaxation process. In most cases these errors are negligible until a rotor is analysed during hover or vortex ring state. In these special cases the wake rollup is more intense leading to relatively small angles. The subsequent errors caused by the singularity protections cannot be ignored since they cause the solutions to be erratic and not smooth. It also causes the wake DVEs to deform disproportionally which is a visual indication of the errors. The modification uses a method that involves splitting the DVE in order to eliminate the errors when calculating the velocity at the junction of two adjacent DVEs. The splitting is temporary and only applied during the calculation of the velocity at the junction. The algorithm for the splitting of the DVE and its implementation into MATLAB is provided in this report. The implementation is tested by ensuring that all conditions are kept the same except when splitting is enabled or disabled. A number of test runs were conducted, and an index called the Smoothness Index was created in order to quantify the improvements of the DVE splitting method. The results shown are promising as the solution with splitting enabled is twice as smooth as when the splitting is disabled. There is also a noticeable improvement during visual comparison of the wake diagrams when splitting is enabled and disabled. The results combined with the fact that the extra computation required to execute the DVE splitting method is negligible, the author recommends it be enabled in all cases. Having said that, the end user has full control whether he or she would like to use it or not. They can also change the parameters of splitting to suit their needs.

Energy-Efficient Optimization of Two-Sided Disassembly Line Balance Considering Parallel Operation and Uncertain Using Multiobjective Flatworm Algorithm

The two-sided disassembly line is popular for its high-efficiency disassembly of large-volume end-of-life products. However, in the process of two-sided disassembly, some parts and components need to be disassembled in parallel, and the uncertainty of disassembly time lacks certain research. This paper constructs a fuzzy multiobjective two-sided disassembly line balance problem model based on parallel operation constraint, which aims to reduce the balance loss rate, smoothness index, and energy consumption of disassembly activities. A multiobjective flatworm algorithm based on the Pareto-dominance relationship is developed. To increase the diversity of feasible solutions in the evolution process and accelerate the convergence of Pareto-optimal solutions to prevent the random search of solution space, growth, splitting and regeneration mechanisms are embedded in the algorithm. The working mechanism and efficiency of the multiobjective flatworm algorithm are proved on a series of two-sided disassembly cases, and the excellent performance of the proposed model and algorithm are demonstrated by an actual automobile two-sided disassembly line.

Brain connectivity and motor improvements after ballet intervention in multiple sclerosis: pilot

Background and PurposeA pilot study to determine feasibility of detecting changes in structural connectivity (SC) and resting-state functional connectivity (RSFC) occur alongside motor improvements after participation in the Targeted Ballet Program (TBP) in adults with relapsing-remitting multiple sclerosis (RRMS).MethodsFive participants (four female) with RRMS between the ages of 38-64 with the following characteristics at baseline: Expanded Disability Status Scale 2.0-6.0, International Cooperative Ataxia Rating Scale (ICARS) > 7, Symbol-Digit Modality Test > 22, and no relapses or initiation of medications indicated to affect mobility within the past 30 days. Participants were asked to complete 12 weeks (one hour, twice per week) of the TBP. Magnetic resonance imaging data was collected pre- and post-intervention for SC and RSFC network analysis.ResultsIncreases in two RRMS-related graph theoretical measures (mean strength and mean clustering coefficient) for RSFC (p < 0.05) are detectable alongside significant reduction in ataxia (ICARS: p = 0.01012, Smoothness Index: p = 0.04995), and increase in balance (Mini-BESTest: p = 0.01474) following participation in the well-tolerated TBP.Discussion and ConclusionsSignificant increases in mean strength and mean clustering coefficient of RSFC suggest functional neurological improvements after participation in the TBP. The relationship between these network changes and clinical improvements in balance and amelioration of ataxia after participation in the TBP requires a larger randomized-controlled clinical trial of the TBP in persons with RRMS.

A CASE STUDY ON SOLAR THERMAL CHIMNEY POWER PLANT IN BHOPAL

The demands and application of electronics goods increase the electricity generation load from non-conventional sources such as wind, solar, and hydro. This clean and green energy laid down the track for future energy demands and reduce carbon emission from the environment. To harness the non-conventional energy, we need to focus on the metrological behaviour to understand solar power generation's smoothness index. To estimate that we need to track down the two crucial parameters, one motion of the sun and another wind flow and its magnitude and direction. Metrological data will help us design the plant for the desired location “Bhopal” and no working days. Therefore, this research paper focused on solar power improvement using metrological data

How to Choose the Optimal Single-Pill Combination of the First-Line Antihypertensive Drugs? The Benefits of Amlodipine and Telmisartan Combination

In patients with arterial hypertension (AH), an extremely important measure of the effectiveness of antihypertensive drugs (AHD) is not only a direct decrease in blood pressure (BP), but also its stable control throughout the 24 hours, preventing excessive morning surge and increased BP variability, which in turn are recognized cardiovascular risk factors. Currently, in the vast majority of hypertensive patients, the main antihypertensive therapy approach is using single-pill combinations (SPC) of AHD. Among the first-line combinations for a wide range of patients with AH and no special clinical conditions is amlodipine/telmisartan SPC. Distinctive features of these drugs, on the one hand, are unique pharmacological properties, consisting in an ultra-long antihypertensive effects, superior to other AHD in their classes; and on the other hand, there is an large body of evidence from numerous clinical trials confirming their high antihypertensive and target-organ protective potential as well as excellent capabilities in cardiovascular risk reduction. To assess the AHD effectiveness extent, several parameters have been proposed, of which the most rational and useful is the smoothness index, calculated using the ambulatory blood pressure monitoring data. Smoothness index describes both the degree of BP reduction and its distribution during the monitoring period. This index inversely associates with the changes in BP variability, and has predictive value in relation to the hypertension-mediated organ damage regression during different antihypertensive regimens. Amlodipine/telmisartan SPC has also been studied in many trials, including comparative ones with other AHD. In these works its direct powerful antihypertensive effect and a pronounced beneficial impact on the smoothness index have been proved, demonstrating stable BP control throughout the 24 hours (especially in the most dangerous morning hours), and also a decrease in BP variability. Therefore, amlodipine/telmisartan SPC can effectively reduce cardiovascular risk and improve prognosis in patients with AH.