Ovarian dysgerminoma with pseudo-Meigs syndrome

Dysgerminoma is an uncommon malignant tumor arising from the germ cells of the ovary. Its association with pregnancy is extremely rare, with a reported incidence of about 0.2–1 per 100,000 pregnancies. Women in the reproductive age group are more commonly affected. It can be extremely rare to conceive naturally, without assisted reproductive interventions, in cases with ovarian dysgerminoma. If a pregnancy does occur with a concurrent dysgerminoma, it is even more unusual to carry the pregnancy to viability or childbirth without fetal or maternal compromise. We report a case of right ovarian dysgerminoma in a young female with a viable intrauterine pregnancy at 10 weeks, which is rarely diagnosed and managed at this gestational age. Numerous factors played a role in her favorable outcome, including early suspicion by ultrasound and presenting history, surgery, histopathological assessment, imaging, and involvement of the multidisciplinary oncology team. Ovarian neoplasms may rapidly increase in size within a short period with little or no symptoms. This poses a diagnostic challenge for obstetricians and oncologists. Hence, we aimed to evaluate the role of imaging in pregnancy using ultrasound as an imaging modality for both early detection of ovarian neoplasms and for follow-up. In conclusion, patients with ovarian dysgerminoma in pregnancy can have favorable outcomes. Treatment should be individualized on a case-to-case basis, depending on many factors; cancer stage, previous reproductive history, the impact of imaging in staging or follow-up of tumor on the fetus, fetal gestational age, and whether termination of the pregnancy can improve survival or morbidity for the mother.

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A Case of Swyer Syndrome Associated with Advanced Gonadal Dysgerminoma Involving Long Survival

Case Reports in Oncology ◽

10.1159/000381451 ◽

2015 ◽

Vol 8 (1) ◽

pp. 179-184 ◽

Cited By ~ 2

Author(s):

Salete Da Silva Rios ◽

Isabella Christina Mazzaro Monteiro ◽

Larissa Gonçalves Braz dos Santos ◽

Natasha Garcia Caldas ◽

Ana Carolina Rios Chen ◽

...

Keyword(s):

Sex Differentiation ◽

Tanner Stage ◽

Pubic Hair ◽

Primary Amenorrhea ◽

Histopathological Analysis ◽

Current Case ◽

Stage 4 ◽

Ovarian Dysgerminoma ◽

The University ◽

Swyer Syndrome

Swyer syndrome is caused by abnormal sex differentiation during the embryonic period, resulting in incomplete intrauterine masculinization and undifferentiated gonads. The current case report describes a patient with Swyer syndrome associated with stage 3 gonadal dysgerminoma who has survived for 23 years. At age 18, this patient sought assistance for primary amenorrhea from the Gynecological Services Department of the University of Brasília Hospital. A physical examination revealed that the patient was at Tanner stage 4 with respect to axillary hair, breasts, and pubic hair; she presented with a eutrophic vagina and a small cervix. She was treated with a combination of estrogens and progestogens to induce cycling. Approximately 4 years later, a complex tumor was found and resected; a histopathological analysis revealed that this tumor was a right adnexal dysgerminoma with peritoneal affection. The patient was also subjected to chemotherapy. Her follow-up has continued to the present time, with no signs of tumor recurrence. In conclusion, this report describes an extremely rare case in which Swyer syndrome was associated with ovarian dysgerminoma; relative to similar patients, the described patient has survived for an unusually prolonged time.

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Ovarian dysgerminoma presenting with hypercalcaemia. Case report and review of the literature

BJOG An International Journal of Obstetrics & Gynaecology ◽

10.1111/j.1471-0528.1990.tb02556.x ◽

1990 ◽

Vol 97 (7) ◽

pp. 641-644 ◽

Cited By ~ 6

Author(s):

A. ANSTEY ◽

L. GOWERS ◽

A. VASS ◽

A. O. ROBSON

Keyword(s):

Case Report ◽

Review Of The Literature ◽

Ovarian Dysgerminoma

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Ovarian Yolk Sac Tumor: A Case Report with Review Of Literature

The Journal of Medical Sciences ◽

10.5005/jp-journals-10045-0026 ◽

2016 ◽

Vol 2 (1) ◽

pp. 15-17

Author(s):

A Sreehari ◽

BM Rupakala

Keyword(s):

Case Report ◽

Early Adulthood ◽

Germ Cell Tumors ◽

Yolk Sac ◽

Immature Teratoma ◽

Yolk Sac Tumor ◽

Histological Subtype ◽

Review Of Literature ◽

Yolk Sac Tumors ◽

Ovarian Dysgerminoma

ABSTRACT A total of 3 to 5% of all ovarian malignancies include malignant ovarian germ cell tumors (MOGCTs). They are subdivided into germinomatous and non-germinomatous tumors. Common types of non-germinomatous tumors include yolk sac and immature teratoma. Ovarian yolk sac tumors (YST) are the second most frequent histological subtype of MOGCTs, after ovarian dysgerminoma. They account for 20% of MOGCTs and are frequent especially in childhood and in early adulthood. We report the case of a yolk sac tumor of the ovary in a 13yrs years old female. How to cite this article Sreehari A, Rupakala BM, Sarojamma C. Ovarian Yolk Sac Tumor: A Case Report with Review of Literature. J Med Sci 2016;2(1):15-17.

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Bilateral ovarian dysgerminoma with metastasis in female dog's mesenteric lymph node: a case report

Brazilian Journal of Case Reports ◽

10.52600/2763-583x.bjcr.2021.1.2.32-41 ◽

2021 ◽

Vol 1 (2) ◽

pp. 32-41

Author(s):

Edgar Tavares de Assis-Neto ◽

Daniel de Araújo Viana ◽

Márcio César Vasconcelos Silva

Keyword(s):

Lymph Node ◽

Histopathological Examination ◽

Present Report ◽

Malignant Neoplasm ◽

Abdominal Distension ◽

Exploratory Laparotomy ◽

Incisional Biopsy ◽

Mesenteric Lymph ◽

Chemotherapy Protocol ◽

Ovarian Dysgerminoma

Dysgerminoma is a rare malignant neoplasm, associated with hormonal dysfunctions, which occurs in canine and feline females from middle age to elderly, without racial predisposition. In the present report, we described a case of ovarian dysgerminoma in a dog, only abdominal distension, persistent vulvar bloody discharge and apathy. The animal in question underwent exploratory laparotomy, where general neoformations were detected in the ovaries, and a lymph node with abnormal characteristics was also found. Therefore, surgery for ovariosalpingoisterectomy and puncture of a fragment of the lymph node altered for incisional biopsy was performed. The diagnosis was made through histopathological examination of the ovaries of the fragment derived from the lymph node, the result of which indicated the presence of dysgerminoma in both ovaries and in the lymph node, characterizing a metastasis. In view of this result, the chemotherapy protocol with the association of carboplatin and vinblastine was instituted, which proved to be effective and not very toxic to the animal, with no clinical sign of metastasis being identified after its use.

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OVARIAN DYSGERMINOMA IN A COW

Australian Veterinary Journal ◽

10.1111/j.1751-0813.1975.tb02391.x ◽

1975 ◽

Vol 51 (10) ◽

pp. 496-496 ◽

Cited By ~ 6

Author(s):

P. M. Summers ◽

J. D. Humphrey ◽

P. A. Bagshaw

Keyword(s):

Ovarian Dysgerminoma

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A Clinical Study of 7 Cases of Ovarian Dysgerminoma

Korean Journal of Gynecologic Oncology and Colposcopy ◽

10.3802/kjgoc.2001.12.4.325 ◽

2001 ◽

Vol 12 (4) ◽

pp. 325

Author(s):

Jin Ho Choi ◽

Jung Yoon Park ◽

Il Soo Park

Keyword(s):

Clinical Study ◽

Ovarian Dysgerminoma

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Late Recurrence in Ovarian Dysgerminoma Presenting as a Primary Retroperitoneal Tumor: A Case Report and Review of the Literature

Case Reports in Pathology ◽

10.1155/2020/4737606 ◽

2020 ◽

Vol 2020 ◽

pp. 1-5

Author(s):

Yuichiro Sato ◽

Tohru Hayashi ◽

Hidetaka Yamamoto ◽

Ichiro Niina ◽

Naoya Kuroki ◽

...

Keyword(s):

Clinical History ◽

Late Recurrence ◽

Retroperitoneal Tumor ◽

Retroperitoneal Mass ◽

Review Of The Literature ◽

Rare Type ◽

History Of ◽

Node Metastases ◽

Ovarian Dysgerminoma ◽

Primary Retroperitoneal

Ovarian dysgerminoma is a rare type of germ cell tumor. The majority of patient relapses occur within 2 years of diagnosis. Here, we report the case of a 74-year-old woman with a history of ovarian dysgerminoma 39 years earlier. The patient visited the hospital presenting with heartburn. An abdominal computed tomography (CT) revealed a right retroperitoneal mass, and a primary retroperitoneal tumor was suspected. She underwent surgical resection of the retroperitoneal tumor. Histological examination confirmed a metastatic dysgerminoma to the retroperitoneum. Postoperative CT showed paraaortic and cervical lymph node metastases. The patient was treated with bleomycin, etoposide, and cisplatin chemotherapy. This case demonstrates the difficulties that may be encountered in the differential diagnosis of a retroperitoneal mass and underlines the necessity for understanding a patient’s clinical history.

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