When in gestation do nutritional alterations exert their effects? A focus on the early origins of adult disease

Severence M MacLaughlin; Beverly S Mühlhäusler; Sheridan Gentili; I Caroline McMillen

doi:10.1097/med.0b013e328010ca30

When in gestation do nutritional alterations exert their effects? A focus on the early origins of adult disease

Current Opinion in Endocrinology & Diabetes ◽

10.1097/med.0b013e328010ca30 ◽

2006 ◽

Vol 13 (6) ◽

pp. 516-522 ◽

Cited By ~ 5

Author(s):

Severence M MacLaughlin ◽

Beverly S Mühlhäusler ◽

Sheridan Gentili ◽

I Caroline McMillen

Keyword(s):

Adult Disease

Download Full-text

Nutritional programming of adult disease

Cell and Tissue Research ◽

10.1007/s00441-005-1095-7 ◽

2005 ◽

Vol 322 (1) ◽

pp. 73-79 ◽

Cited By ~ 27

Author(s):

Alex J. Buckley ◽

Anne L. Jaquiery ◽

Jane E. Harding

Keyword(s):

Adult Disease ◽

Nutritional Programming

Download Full-text

Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19

Science Immunology ◽

10.1126/sciimmunol.abf7570 ◽

2021 ◽

Vol 6 (57) ◽

pp. eabf7570

Author(s):

Laura A. Vella ◽

Josephine R. Giles ◽

Amy E. Baxter ◽

Derek A. Oldridge ◽

Caroline Diorio ◽

...

Keyword(s):

T Cells ◽

T Cell ◽

T Cell Activation ◽

Cd8 T Cells ◽

Immune Activation ◽

Cell Activation ◽

Vascular Complications ◽

Adult Disease ◽

Vasoactive Medication ◽

Inflammatory Syndrome

Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children, however, present with Multisystem Inflammatory Syndrome in Children (MIS-C) that can lead to vascular complications and shock, but rarely death. The immune features of MIS-C compared to pediatric COVID-19 or adult disease remain poorly understood. We analyzed peripheral blood immune responses in hospitalized SARS-CoV-2 infected pediatric patients (pediatric COVID-19) and patients with MIS-C. MIS-C patients had patterns of T cell-biased lymphopenia and T cell activation similar to severely ill adults, and all patients with MIS-C had SARS-CoV-2 spike-specific antibodies at admission. A distinct feature of MIS-C patients was robust activation of vascular patrolling CX3CR1+ CD8+ T cells that correlated with the use of vasoactive medication. Finally, whereas pediatric COVID-19 patients with acute respiratory distress syndrome (ARDS) had sustained immune activation, MIS-C patients displayed clinical improvement over time, concomitant with decreasing immune activation. Thus, non-MIS-C versus MIS-C SARS-CoV-2 associated illnesses are characterized by divergent immune signatures that are temporally distinct from one another and implicate CD8+ T cells in the clinical presentation and trajectory of MIS-C.

Download Full-text

OC076: Fetal origin of adult disease in view of the antenatal ultrasound studies

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.289 ◽

2003 ◽

Vol 22 (S1) ◽

pp. 22-22

Author(s):

K. Marsal ◽

J. Brodszki ◽

H. M. Gardiner ◽

A. Hellstr�m ◽

L. Martin ◽

...

Keyword(s):

Ultrasound Studies ◽

Antenatal Ultrasound ◽

Adult Disease ◽

Fetal Origin

Download Full-text

Classic Nephropathic Cystinosis as an Adult Disease

JAMA ◽

10.1001/jama.1993.03510180070036 ◽

1993 ◽

Vol 270 (18) ◽

pp. 2200 ◽

Cited By ~ 50

Author(s):

Demetrios S. Theodoropoulos

Keyword(s):

Nephropathic Cystinosis ◽

Adult Disease

Download Full-text

Fetal origins of adult disease

British Journal Of Nutrition ◽

10.1017/s0007114599000070 ◽

1999 ◽

Vol 81 (1) ◽

pp. 5-6 ◽

Cited By ~ 15

Author(s):

Simon C. Langley-Evans

Keyword(s):

Fetal Origins ◽

Adult Disease

Download Full-text

Body composition in childhood: effects of normal growth and disease

Proceedings of The Nutrition Society ◽

10.1079/pns2003261 ◽

2003 ◽

Vol 62 (2) ◽

pp. 521-528 ◽

Cited By ~ 38

Author(s):

J. C. K. Wells

Keyword(s):

Body Composition ◽

Childhood Obesity ◽

Fat Mass ◽

Lean Mass ◽

Normal Weight ◽

Fat Free Mass ◽

General Interest ◽

Childhood And Adolescence ◽

Adult Disease ◽

Increased Risk

Body composition in children is of increasing interest within the contexts of childhood obesity, clinical management of patients and nutritional programming as a pathway to adult disease. Energy imbalance appears to be common in many disease states; however, body composition is not routinely measured in patients. Traditionally, clinical interest has focused on growth or nutritional status, whereas more recent studies have quantified fat mass and lean mass. The human body changes in proportions and chemical composition during childhood and adolescence. Most of the weight gain comprises lean mass rather than fat. In general, interest has focused on percentage fat, and less attention has been paid to the way in which lean mass varies within and between individuals. In the general population secular trends in BMI have been widely reported, indicating increasing levels of childhood obesity, which have been linked to reduced physical activity. However, lower activity levels may potentially lead not only to increased fatness, but also to reduced lean mass. This issue merits further investigation. Diseases have multiple effects on body composition and may influence fat-free mass and/or fat mass. In some diseases both components change in the same direction, whereas in other diseases, the changes are contradictory and may be concealed by relatively normal weight. Improved techniques are required for clinical evaluations. Both higher fatness and reduced lean mass may represent pathways to an increased risk of adult disease.

Download Full-text