Gene expression profiling in head and neck squamous cell carcinoma

2010 ◽  
Vol 18 (2) ◽  
pp. 67-71 ◽  
Author(s):  
Boudewijn JM Braakhuis ◽  
Ruud H Brakenhoff ◽  
C René Leemans
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Gene Expression Profiling ◽  
Squamous Cell ◽  
Expression Profiling ◽  
Neck Squamous Cell Carcinoma

Gene expression profiling predicts nonresponders to chemoradiation in HPV16-positive head and neck squamous cell carcinoma.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. 5589-5589
Author(s):  
B. J. Thibodeau ◽  
T. J. Geddes ◽  
S. Ahmed ◽  
B. L. Pruetz ◽  
P. Y. Chen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Gene Expression Profiling ◽  
Squamous Cell ◽  
Expression Profiling ◽  
Neck Squamous Cell Carcinoma

Gene expression profiling on pre- and post-erlotinib tumors from patients with head and neck squamous cell carcinoma

Head & Neck ◽  
2012 ◽  
Vol 35 (6) ◽  
pp. 809-818 ◽  
Author(s):  
Fabienne Thomas ◽  
Paul Delmar ◽  
Sébastien Vergez ◽  
Philippe Rochaix ◽  
Isabelle Hennebelle ◽  
...  
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Gene Expression Profiling ◽  
Squamous Cell ◽  
Expression Profiling ◽  
Neck Squamous Cell Carcinoma

scholarly journals Gene expression profiling of head and neck squamous cell carcinoma using cDNA microarrays

2006 ◽  
Author(s):  
Stefan Gottschlich ◽  
Petra Ambrosch ◽  
Christian Cordes ◽  
Tibor Görögh ◽  
Stefan Schreiber ◽  
...  
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Gene Expression Profiling ◽  
Squamous Cell ◽  
Expression Profiling ◽  
Cdna Microarrays ◽  
Neck Squamous Cell Carcinoma

Gene expression profiling in head and neck squamous cell carcinoma: Clinical perspectives

Head & Neck ◽  
2010 ◽  
Vol 32 (12) ◽  
pp. 1712-1719 ◽  
Author(s):  
Benjamin Lallemant ◽  
Alexandre Evrard ◽  
Guillaume Chambon ◽  
Omar Sabra ◽  
Sophie Kacha ◽  
...  
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Gene Expression Profiling ◽  
Squamous Cell ◽  
Expression Profiling ◽  
Neck Squamous Cell Carcinoma

scholarly journals Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jili Cui ◽  
Lian Zheng ◽  
Yuanyuan Zhang ◽  
Miaomiao Xue
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Immune Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Hub Genes ◽  
Significant Difference ◽  
Dnmt1 Expression

AbstractHead and neck squamous cell carcinoma (HNSCC) is the sixth most common type of malignancy in the world. DNA cytosine-5-methyltransferase 1 (DNMT1) play key roles in carcinogenesis and regulation of the immune micro-environment, but the gene expression and the role of DNMT1 in HNSCC is unknown. In this study, we utilized online tools and databases for pan-cancer and HNSCC analysis of DNMT1 expression and its association with clinical cancer characteristics. We also identified genes that positively and negatively correlated with DNMT1 expression and identified eight hub genes based on protein–protein interaction (PPI) network analysis. Enrichment analyses were performed to explore the biological functions related with of DNMT1. The Tumor Immune Estimation Resource (TIMER) database was performed to explore the relationship between DNMT1 expression and immune-cell infiltration. We demonstrated that DNMT1 gene expression was upregulated in HNSCC and associated with poor prognosis. Based on analysis of the eight hub genes, we determined that DNMT1 may be involved in cell cycle, proliferation and metabolic related pathways. We also found that significant difference of B cells infiltration based on TP 53 mutation. These findings suggest that DNMT1 related epigenetic alterations have close relationship with HNSCC progression, and DNMT1 could be a novel diagnostic biomarker and a promising therapeutic target for HNSCC.

scholarly journals Assessing Various Control Samples for Microarray Gene Expression Profiling of Laryngeal Squamous Cell Carcinoma

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 588
Author(s):  
Adam Ustaszewski ◽  
Magdalena Kostrzewska-Poczekaj ◽  
Joanna Janiszewska ◽  
Malgorzata Jarmuz-Szymczak ◽  
Malgorzata Wierzbicka ◽  
...  
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
Epithelial Cells ◽  
Cell Carcinoma ◽  
Gene Expression Profiling ◽  
Cell Lines ◽  
Squamous Cell ◽  
Expression Profiling ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Control Samples

Selection of optimal control samples is crucial in expression profiling tumor samples. To address this issue, we performed microarray expression profiling of control samples routinely used in head and neck squamous cell carcinoma studies: human bronchial and tracheal epithelial cells, squamous cells obtained by laser uvulopalatoplasty and tumor surgical margins. We compared the results using multidimensional scaling and hierarchical clustering versus tumor samples and laryngeal squamous cell carcinoma cell lines. A general observation from our study is that the analyzed cohorts separated according to two dominant factors: “malignancy”, which separated controls from malignant samples and “cell culture-microenvironment” which reflected the differences between cultured and non-cultured samples. In conclusion, we advocate the use of cultured epithelial cells as controls for gene expression profiling of cancer cell lines. In contrast, comparisons of gene expression profiles of cancer cell lines versus surgical margin controls should be treated with caution, whereas fresh frozen surgical margins seem to be appropriate for gene expression profiling of tumor samples.

Targeted gene expression profiling of inverted papilloma and squamous cell carcinoma

2021 ◽  
Author(s):  
Charles C. L. Tong ◽  
Mateusz Koptyra ◽  
Pichai Raman ◽  
Komal S. Rathi ◽  
Namrata Choudhari ◽  
...  
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Gene Expression Profiling ◽  
Squamous Cell ◽  
Expression Profiling ◽  
Inverted Papilloma ◽  
Targeted Gene Expression
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