scholarly journals Apigenin Inhibits NNK-Induced Focal Adhesion Kinase Activation in Pancreatic Cancer Cells

Pancreas ◽  
2012 ◽  
Vol 41 (8) ◽  
pp. 1306-1315 ◽  
Author(s):  
Hung Pham ◽  
Monica Chen ◽  
Hiroki Takahashi ◽  
Jonathan King ◽  
Howard A. Reber ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Focal Adhesion Kinase ◽  
Cancer Cells ◽  
Focal Adhesion ◽  
Kinase Activation ◽  
Pancreatic Cancer Cells

Tissue Transglutaminase Regulates Focal Adhesion Kinase/AKT Activation by Modulating PTEN Expression in Pancreatic Cancer Cells

2008 ◽  
Vol 14 (7) ◽  
pp. 1997-2005 ◽  
Author(s):  
Amit Verma ◽  
Sushovan Guha ◽  
Huamin Wang ◽  
Jansina Y. Fok ◽  
Dimpy Koul ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Focal Adhesion Kinase ◽  
Cancer Cells ◽  
Focal Adhesion ◽  
Tissue Transglutaminase ◽  
Pten Expression ◽  
Akt Activation ◽  
Pancreatic Cancer Cells

scholarly journals PAUF promotes adhesiveness of pancreatic cancer cells by modulating focal adhesion kinase

2011 ◽  
Vol 43 (5) ◽  
pp. 291 ◽  
Author(s):  
Yangsoon Lee ◽  
Su Jin Kim ◽  
Hye Jin Min ◽  
Ji Yoon Jo ◽  
Eun Hye Park ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Focal Adhesion Kinase ◽  
Cancer Cells ◽  
Focal Adhesion ◽  
Pancreatic Cancer Cells

scholarly journals Insulin Receptor Substrate Is a Mediator of Phosphoinositide 3-Kinase Activation in Quiescent Pancreatic Cancer Cells

2005 ◽  
Vol 65 (20) ◽  
pp. 9164-9168 ◽  
Author(s):  
Takayuki Asano ◽  
Yixin Yao ◽  
Sonyo Shin ◽  
James McCubrey ◽  
James L. Abbruzzese ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Insulin Receptor ◽  
Cancer Cells ◽  
Insulin Receptor Substrate ◽  
Kinase Activation ◽  
Pancreatic Cancer Cells ◽  
Phosphoinositide 3 Kinase

scholarly journals Focal adhesion kinase inhibitor PF573228 and death receptor 5 agonist lexatumumab synergistically induce apoptosis in pancreatic carcinoma

Tumor Biology ◽  
2017 ◽  
Vol 39 (5) ◽  
pp. 101042831769912 ◽  
Author(s):  
Xiangxuan Zhao ◽  
Wei Sun ◽  
William M Puszyk ◽  
Shannon Wallet ◽  
Steve Hochwald ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Pancreatic Carcinoma ◽  
Cancer Cells ◽  
Focal Adhesion ◽  
Kinase Inhibitor ◽  
Death Receptor ◽  
Death Receptor 5 ◽  
Pancreatic Cancer Cells ◽  
Induced Apoptosis ◽  
Cancer Tissues

Pancreatic cancer has one of the lowest survival rates of all cancers. The mechanism underlying chemo-resistance of pancreatic cancer is not well understood. Our previous article reported that small molecule YM155 induced apoptosis in pancreatic cancer cells via activation of death receptor 5. In this study, we aim to continuously address death receptor 5–mediated apoptosis in chemo-resistant pancreatic carcinoma. We found that in comparison to paired pancreatic cancer tissues and adjacent normal tissues, five of the six cancer tissues had downregulated death receptor 5 and upregulated Bcl-xL. Mono treatment with lexatumumab was not sufficient to induce apoptosis in pancreatic cancer cells, whereas focal adhesion kinase inhibitor PF573228 significantly sensitized lexatumumab-induced apoptosis. Western blotting analysis revealed that lexatumumab and PF573228 combination treatment increased death receptor 5 but decreased Bcl-xL expression. Interestingly, pre-treatment with Bcl-xL inhibitor ABT263 reversed the insensitivity of panc-1 cells to lexatumumab or PF573228-induced apoptosis. Specific small interfering RNA-mediated gene silencing of Bcl-xL effectively sensitized pancreatic cancer cells to lexatumumab or PF573228-induced apoptosis. Furthermore, lexatumumab and PF573228 combination was shown to exhibit significant xenograft pancreatic tumor growth inhibition in SCID mice. Our data provide fundamental evidence to support the notion that lexatumumab and PF573228 co-treatment could be a potentially effective regime for patients with pancreatic cancer.

Coexpression of UCA1 and ITGA2 in pancreatic cancer cells target the expression of miR‐107 through focal adhesion pathway

2018 ◽  
Vol 234 (8) ◽  
pp. 12884-12896 ◽  
Author(s):  
Jun Gong ◽  
Xiangyu Lu ◽  
Jian Xu ◽  
Wei Xiong ◽  
Hao Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Focal Adhesion ◽  
Pancreatic Cancer Cells ◽  
Focal Adhesion Pathway

Synergistic effects of retrovirus IFN-α gene transfer and gemcitabine on apoptosis of pancreatic cancer cells

2001 ◽  
Vol 120 (5) ◽  
pp. A615-A615
Author(s):  
M GORSCHLUETER ◽  
B SCHOETTKER ◽  
A MAERTEN ◽  
C ZISKE
Keyword(s):  
Pancreatic Cancer ◽  
Gene Transfer ◽  
Cancer Cells ◽  
Synergistic Effects ◽  
Pancreatic Cancer Cells

Standardized herbal extracts of Japanese Kampo medicine and their effects on human and murine pancreatic cancer cells

2019 ◽  
Author(s):  
K Kuchta ◽  
K Weimer ◽  
L Frank ◽  
H Rausch ◽  
V Ellenrieder ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Kampo Medicine ◽  
Herbal Extracts ◽  
Pancreatic Cancer Cells
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