Lack of Correlation of Mean Corpuscular Volume to White Blood Cell Ratio to Thiopurine Levels

2020 ◽  
Vol 70 (5) ◽  
pp. e107-e110 ◽  
Author(s):  
Jan de Laffolie ◽  
Sibylle Koletzko ◽  
Stephan Buderus ◽  
Martin Classen ◽  
Carsten Posovszky ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Mean Corpuscular Volume ◽  
Corpuscular Volume ◽  
Cell Ratio

scholarly journals Hematologic differences between African-Americans and whites: the roles of iron deficiency and α-thalassemia on hemoglobin levels and mean corpuscular volume

Blood ◽  
2005 ◽  
Vol 106 (2) ◽  
pp. 740-745 ◽  
Author(s):  
Ernest Beutler ◽  
Carol West
Keyword(s):  
African American ◽  
African Americans ◽  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell ◽  
Mean Corpuscular Volume ◽  
Corpuscular Volume ◽  
Blood Cell Count ◽  
Iron Deficient ◽  
The Difference

Abstract The average results of some laboratory measurements, including the hemoglobin, mean corpuscular volume (MCV), serum transferrin saturation (TS), serum ferritin, and white blood cell count of African-Americans differ from those of whites. Anonymized samples and laboratory data from 1491 African-American and 31 005 white subjects, approximately equally divided between men and women, were analyzed. The hematocrit, hemoglobin, MCV, TS, and white blood cell counts of African-Americans were lower than those of whites; serum ferritin levels were higher. When iron-deficient patients were eliminated from consideration the differences in hematocrit, hemoglobin, and MCV among women were slightly less. The -3.7-kilobase α-thalassemia deletion accounted for about one third of the difference in the hemoglobin levels of African-Americans and whites and neither sickle trait nor elevated creatinine levels had an effect. Among all subjects, 19.8% of African-American women would have been classified as “anemic” compared with 5.3% of whites. Among men, the figures were 17.7% and 7.6%. Without iron-deficient or thalassemic subjects, the difference had narrowed to 6.1% and 2.77% and to 4.29% and 3.6%, respectively. Physicians need to take into account that the same reference standards for hemoglobin, hematocrit, MCV, and TS and the white blood cell count do not apply to all ethnic groups. (Blood. 2005;106:740-745)

scholarly journals Validation of the Medonic CA620/530 Vet 20-μ1 Microcapillary Sampler System for Hematology Testing of Feline Blood

2009 ◽  
Vol 21 (3) ◽  
pp. 364-368 ◽  
Author(s):  
H. Bourgès-Abella Nathalie ◽  
Brice S. Reynolds ◽  
Geffré Anne ◽  
Jean-Pierre Braun ◽  
Catherine Trumel
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Red Blood Cell ◽  
Mean Corpuscular Volume ◽  
Hemoglobin Concentration ◽  
Sampling Techniques ◽  
Corpuscular Volume ◽  
Small Species ◽  
Repeated Sampling ◽  
Veterinary School

The aim of the current study was to compare feline hematologic variables in blood collected in microcapillary tubes (20 μl) and conventional blood tubes with the Medonic CA620/530 Vet in-house hematologic analyzer. A comparison of results obtained in 60 cats presented at the clinics of the veterinary school showed that the correlations between the 2 methods were 0.97 for white blood cell, 0.95 for red blood cell, and 0.93 for platelet counts; 0.92 for hemoglobin concentration; and 0.99 for mean corpuscular volume. No clinically relevant differences between the 2 blood sampling techniques were observed for any variable, which suggests that both techniques are interchangeable in cats. Moreover, microcapillary tubes would allow easier repeated sampling in the same cat and would likely be useful in other small species.

scholarly journals Evaluation of Haematological Alterations in Children Infected by Plasmodium falciparum Species in Enugu, Enugu State, Nigeria

2021 ◽  
pp. 38-45
Author(s):  
Linda Nnenna Ogbonna ◽  
Silas Anayo Ufelle ◽  
Emmanuel Ifeanyi Obeagu ◽  
Cyril Okonkwo Ogbonna
Keyword(s):  
Plasmodium Falciparum ◽  
Blood Cell ◽  
Falciparum Malaria ◽  
White Blood Cell ◽  
Mean Corpuscular Volume ◽  
Corpuscular Volume ◽  
Infected Male ◽  
Corpuscular Haemoglobin ◽  
Mean Corpuscular Haemoglobin ◽  
Enugu State

Malaria accounts for a considerable amount of Morbidity and mortality with children bearing the greatest burden. The study aimed to investigate the haematological alterations in children infected by Plasmodium falciparum (P. falciparum) species. A case control study with a total of ninety-five microscopically confirmed P. falciparum malaria infected children and fifty apparently healthy age and gender matched controls from Enugu State University Teaching Hospital, Parklane, Wesley Specialist Hospital and Akpugo Community Health Centre, Enugu were recruited for the study. Haematologic parameters were estimated using five part differential automated analyzer (Mindray BC 5300) with ethylene-diamine-tetra-acetic-acid anticoagulated blood. ­­The result of P. falciparum infected male children revealed significant decrease (p < 0.05) in haematocrit (32.76 + 4.82)%, haemoglobin  (10.34 + 1.46) g/dl, white blood cell (3.65 + 2.81)x109/L, neutrophil (20.41 + 15.16)% and platelet (228.41 + 113.51) x109/L, compared to  the controls; haematocrit (35.60 + 2.70)%, haemoglobin (11.27 + 0.90) g/dl; white blood cell (7.97 + 2.55)x109/L, neutrophil (30.33 + 8.04)% and platelet (315.45 + 53.64) x 109/L.  It also showed a significant increase (p < 0.05) in monocyte (3.28 + 2.63)%, basophil (1.68 + 1.15)% compared to the controls; monocyte (1.89 + 1.10)%, basophil (0.44 + 0.46)%. The results of P. falciparum infected female children revealed significant decrease (p < 0.05) in white blood cell (4.93 + 2.95)x109/L, neutrophil (19.61 + 15.14)%, mean corpuscular haemoglobin (23.58 + 2.37)pg, mean corpuscular volume (74.67 + 8.00)fl, and platelet (257.00 + 129.55) x109/L compared to the controls; white blood cell (6.70 + 1.75) x109/L, neutrophil (26.91 + 7.97)%, mean corpuscular haemoglobin (25.12 + 1.96)pg, mean corpuscular volume (79.13 + 5.37) fl and platelet (303.13 + 54.02) x109/L, significantly increased (p < 0.05) monocyte (3.38 + 2.78)%, basophil (2.19 + 1.36)% as compared to the controls; monocyte (1.85 + 0.82)%, basophil (0.48 + 0.45)%. However, P. falciparum infected male children showed to be more anaemic compared to the infected females.  Indeed, Plasmodium falciparum malaria infection in children has great impact on the haematologic parameters, thus its investigations serves as competent measures of differential diagnosis.

Diagnostic value of post-operative platelet-to-white blood cell ratio after splenectomy in patients with advanced ovarian cancer

2019 ◽  
Vol 29 (8) ◽  
pp. 1292-1297 ◽  
Author(s):  
Konstantinos Lathouras ◽  
Georgios Panagakis ◽  
Sarah Joanne Bowden ◽  
Konstantinos Saliaris ◽  
Srdjan Saso ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Platelet Count ◽  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Predictive Value ◽  
Blood Cell Count ◽  
Cell Ratio ◽  
Grade Iii

IntroductionSplenectomy-induced thrombocytosis and leukocytosis may obscure the early diagnosis of post-operative infection or sepsis. In trauma patients after splenectomy, a platelet-to-white blood cell ratio of <20 has been shown to reliably differentiate post-operative sepsis from transient physiological responses.ObjectiveTo determine whether the platelet-to-white blood cell ratio can be applied to differentiate between reactive post-operative changes and latent infection.MethodsAll consecutive patients with ovarian cancer who underwent splenectomy between January 2013 and October 2018 in two large European gynecological cancer centers were retrospectively evaluated. Main outcome measures were white blood cell count, platelet count, and platelet-to-white blood cell ratio on post-operative days 1, 5, and 7. These were correlated with surgical outcome and morbidity according to the Clavien-Dindo classification. A binomial logistic regression was applied to assess the predictive value of day 5 platelet-to-white blood cell ratio, white blood cell count, and platelet count for predicting grade III post-operative sepsis.ResultsNinety-five patients with ovarian cancer (mean age 54 years, range 18–75) were identified. Seventeen patients (17.9%) developed a grade III post-operative sepsis. In all post-operative patients, mean white blood cell count on day 5 decreased (from 15.4×103/μL to 11.4×103/μL), while the mean platelet count rose (from 260.7×103/μL to 385.3×103/μL). A high platelet count (>313×103/μL) failed to show any predictive value (OR=0.94; 95% CI 0.30 to 3.0; p=0.921). A low platelet-to-white blood cell ratio (<26) (OR=3.49; 95% CI 1.18 to 10.32; p=0.0241) and high white blood cell count (>14.5×103/μL) on day 5 (OR=11.0; 95% CI 3.3 to 36.2; p<0.001) were significant for predicting sepsis. Despite a significant OR, the sensitivity and specificity were low; day 5 platelet-to-white blood cell ratio at a cut-off point of 26 achieved a sensitivity of 72% and specificity of 53% (area under the curve 0.637, 95% CI 0.480 to 0.796) in predicting grade III post-operative sepsis.ConclusionsPlatelet-to-white blood cell ratio after cytoreductive surgery for ovarian cancer with splenectomy does not appear to have a strong predictive value in differentiating between sepsis and reactive splenectomy-induced changes. Leukocytosis, in combination with clinical assessment, may remain the most useful tool for prediction of sepsis after cytoreductive surgery with splenectomy.

scholarly journals Platelet to white blood cell ratio predicts 30-day postoperative infectious complications in patients undergoing radical nephrectomy for renal malignancy

2017 ◽  
Vol 11 (11) ◽  
pp. E414-20 ◽  
Author(s):  
Alaina Garbens ◽  
Christopher J.D. Wallis ◽  
Georg Bjarnason ◽  
Girish S. Kulkarni ◽  
Avery B. Nathens ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Radical Nephrectomy ◽  
External Validation ◽  
Infectious Complications ◽  
Bleeding Complications ◽  
Improvement Program ◽  
Cell Ratio ◽  
Increased Risk ◽  
The Relationship

Introduction: We sought to examine the relationship between preoperative platelet to white blood cell ratio (PLT/WBC), a hematological marker of the systemic inflammatory response, and postoperative infectious complications following radical nephrectomy for localized renal cell carcinoma.Methods: We performed a retrospective cohort study of patients treated with radical nephrectomy for localized kidney cancer between January 1, 2005 and December 31, 2014 (n=6235) using the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) database. Univariate and multivariate analyses were used to assess the association between PLT/ WBC ratio and 30-day infectious complications, including surgical site infection, urinary tract infection (UTI), pneumonia, and sepsis. Secondarily, we examined major complications and bleeding requiring transfusion.Results: A lower PLT/WBC ratio was associated with an increased risk of sepsis, pneumonia, and UTI rates (p<0.05 for all). Furthermore, there was a significant trend of decreasing rates of sepsis and pneumonia with increasing PLT/WBC ratio across quintiles (p<0.05 for all). On multivariate analysis, patients with the lowest PLT/WBC ratios (Quintile 1) had a two-fold risk of having a postoperative infectious complication compared to patients in the highest quintile (odds ratio [OR] 2.01; 95% confidence interval [CI] 1.42–2.86; p<0.0001). Patients in Quintile 5 had a higher risk of requiring blood transfusion than those in Quintiles 2‒4 (p<0.05 for all).Conclusions: The PLT/WBC ratio represents a widely available and novel index to predict risk of infectious and bleeding complications in patients undergoing radical nephrectomy. External validation is required and the biological underpinning of this phenomenon requires further study

Determining mean corpuscular volume and red blood cell count using electrochemical collision events

2018 ◽  
Vol 110 ◽  
pp. 155-159 ◽  
Author(s):  
Thy L.T. Ho ◽  
Nhung T.T. Hoang ◽  
Jungeun Lee ◽  
Jun Hui Park ◽  
Byung-Kwon Kim
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Red Blood Cell ◽  
Mean Corpuscular Volume ◽  
Corpuscular Volume ◽  
Blood Cell Count ◽  
Red Blood Cell Count
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