Tumor Necrosis Factor-??, Interleukin-10, and ??-Defensins in Plasma and Breast Milk of HIV-Infected Highly Active Antiretroviral Therapy-Treated and Untreated Pregnant Women in Mozambique

2008 ◽  
Vol 47 (5) ◽  
pp. 647-649 ◽  
Author(s):  
Silvia Baroncelli ◽  
Mauro Andreotti ◽  
Giovanni Guidotti ◽  
Maria F Pirillo ◽  
Susanna Ceffa ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Tumor Necrosis Factor ◽  
Breast Milk ◽  
Pregnant Women ◽  
Highly Active Antiretroviral Therapy ◽  
Tumor Necrosis ◽  
Interleukin 10 ◽  
Highly Active ◽  
Necrosis Factor

scholarly journals Effect of Synbiotic on Interleukin 10 and Tumor Necrosis Factor-α Serum Level in Pregnant Women with Bacterial Vaginosis

2018 ◽  
Vol 11 (1) ◽  
pp. 14-19
Author(s):  
Natami Dewi Ratih ◽  
Aditya Zulfikar ◽  
St. Maisuri T. ◽  
Fatmawati Madya ◽  
Sharvianty Arifuddin ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Serum Level ◽  
Bacterial Vaginosis ◽  
Pregnant Women ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 10 ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Effect of Structured Physical Activity on Inflammation and Immune Activation Profile of Antiretroviral Therapy-Experienced Children Living With HIV

2020 ◽  
Vol 32 (2) ◽  
pp. 73-80
Author(s):  
Bindu P. Gopalan ◽  
Mary Dias ◽  
Karthika Arumugam ◽  
Reena R. D’Souza ◽  
Mathew Perumpil ◽  
...  
Keyword(s):  
Physical Activity ◽  
Antiretroviral Therapy ◽  
Tumor Necrosis Factor ◽  
Immune Activation ◽  
Tumor Necrosis ◽  
Interleukin 2 ◽  
Interleukin 10 ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

Aim: To compare the markers of inflammation and immune activation in virally suppressed HIV-infected children on antiretroviral therapy, who practiced regular structured exercise comprising running and yoga to those who did not over a 2-year period. Methods: This retrospective cohort study included 72 children aged 8 to 16 years divided into 2 groups, exercisers (n = 36) and the nonexercisers (n = 36) based on their intentional physical activity. The analyses were carried out at baseline and after 2 years (Y2) for the soluble biomarkers of inflammation and immune activation (tumor necrosis factor alpha, interleukin-6, interleukin-10, interferon gamma, sCD14, and sCD163). In addition, cell-associated biomarker (CD38), lipopolysaccharides, and the gene expression of interleukin-2 and brain-derived neurotrophic factor were also measured at Y2. Results: Reduction in levels of sCD14 (effect size [ES], −0.6; 95% confidence interval [CI], −1.08 to −0.14), tumor necrosis factor alpha (ES, −0.7; 95% CI, −1.18 to −0.23), interferon gamma (ES, −0.7; 95% CI, −1.17 to −0.22), and interleukin-10 (ES, −0.6; 95% CI, −1.08 to −0.14) was observed among exercisers as compared with nonexercisers at Y2. In addition, CD38+ expressing CD4+ T cells were found to be lower among exercisers (P = .01) at Y2. However, the differences in levels of interleukin-6, sCD163, lipopolysaccharides, interleukin-2, and brain-derived neurotrophic factor were not significantly different among the 2 groups. Conclusion: The study result suggests that regular structured physical activity improves the inflammatory profile of antiretroviral therapy-treated HIV-infected children.

scholarly journals Genetic Variations in Tumor Necrosis Factor Alpha, Interleukin-10 Genes, and Migraine Susceptibility

Pain Medicine ◽  
2011 ◽  
Vol 12 (10) ◽  
pp. 1464-1469 ◽  
Author(s):  
Omer Ates ◽  
Semiha Kurt ◽  
Julide Altinisik ◽  
Hatice Karaer ◽  
Saime Sezer
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Interleukin 10 ◽  
Genetic Variations ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Targeted Deletion of Class A Macrophage Scavenger Receptor Increases the Risk of Cardiac Rupture After Experimental Myocardial Infarction

Circulation ◽  
2007 ◽  
Vol 115 (14) ◽  
pp. 1904-1911 ◽  
Author(s):  
Kenichi Tsujita ◽  
Koichi Kaikita ◽  
Takanori Hayasaki ◽  
Tsuyoshi Honda ◽  
Hironori Kobayashi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 10 ◽  
Experimental Myocardial Infarction ◽  
Cardiac Rupture ◽  
Infarcted Myocardium ◽  
Factor Α ◽  
Necrosis Factor

Background— Class A macrophage scavenger receptor (SR-A) is a macrophage-restricted multifunctional molecule that optimizes the inflammatory response by modulation of the activity of inflammatory cytokines. This study was conducted with SR-A–deficient (SR-A −/− ) mice to evaluate the relationship between SR-A and cardiac remodeling after myocardial infarction. Methods and Results— Experimental myocardial infarction (MI) was produced by ligation of the left coronary artery in SR-A −/− and wild-type (WT) male mice. The number of mice that died within 4 weeks after MI was significantly greater in SR-A −/− mice than in WT mice ( P =0.03). Importantly, death caused by cardiac rupture within 1 week after MI was 31% (17 of 54 mice) in SR-A −/− mice and 12% (6 of 51 mice) in WT mice ( P =0.01). In situ zymography demonstrated augmented gelatinolytic activity in the infarcted myocardium in SR-A −/− mice compared with WT mice. Real-time reverse transcription–polymerase chain reaction at day 3 after MI showed that the expression of matrix metalloproteinase-9 mRNA increased significantly in the infarcted myocardium in SR-A −/− mice compared with WT mice. Furthermore, SR-A −/− mice showed augmented expression of tumor necrosis factor-α and reduction of interleukin-10 in the infarcted myocardium at day 3 after MI. In vitro experiments also demonstrated increased tumor necrosis factor-α and decreased interleukin-10 expression in activated SR-A −/− macrophages. Conclusions— The present findings suggest that SR-A deficiency might cause impairment of infarct remodeling that results in cardiac rupture via insufficient production of interleukin-10 and enhanced expression of tumor necrosis factor-α and of matrix metalloproteinase-9. SR-A might contribute to the prevention of cardiac rupture after MI.

Lipopolysaccharide-induced interleukin-10 in mice: role of endogenous tumor necrosis factor-α

1995 ◽  
Vol 25 (10) ◽  
pp. 2888-2893 ◽  
Author(s):  
Johannes Barsig ◽  
Sabine Küsters ◽  
Kathrin Vogt ◽  
Hans-Dieter Volk ◽  
Gisa Tiegs ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 10 ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Successful management of HIV infection in a patient with ulcerative colitis; a case report

2021 ◽  
Vol 6 (1) ◽  
pp. e17-e17
Author(s):  
Zain Majid ◽  
Shoaib Ahmed Khan ◽  
Hina Ismail ◽  
Nishat Akbar ◽  
Rajesh Mandhwani ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Ulcerative Colitis ◽  
Hiv Infection ◽  
Highly Active Antiretroviral Therapy ◽  
Tumor Necrosis ◽  
Successful Management ◽  
Highly Active ◽  
Resource Limited ◽  
Immunodeficiency Virus ◽  
Necrosis Factor

Human immunodeficiency virus (HIV) is an infectious disease that is rarely seen in ulcerative colitis patients. Both diseases commonly involve the colon. It has been shown that treating these patients with anti-tumor necrosis factor (anti-TNF) therapy leads to remission of both conditions. We hereby present the case of a 7-year-old boy who was initially managed as a case ulcerative colitis after undergoing extensive workup and later on tested positive for HIV infection and was managed via mesalamine and highly active antiretroviral therapy (HAART). Mesalamine therapy along with HAART can be used to treat ulcerative colitis patients infected with HIV infection in resource limited countries.

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