Clinical and Prognostic Factors Associated With Survival in Mexican Patients With Idiopathic Inflammatory Myopathies

2016 ◽  
Vol 22 (2) ◽  
pp. 51-56 ◽  
Author(s):  
Angeles Shunashy Galindo-Feria ◽  
Jorge Rojas-Serrano ◽  
Andrea Hinojosa-Azaola
Keyword(s):  
Prognostic Factors ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Factors Associated ◽  
Mexican Patients

scholarly journals FRI0248 PROGNOSTIC FACTORS FOR STEROID-FREE REMISSION IN PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHIES: IMPORTANCE OF ANTHROPOMETRIC MEASUREMENTS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 708.1-708
Author(s):  
J. S. Lee ◽  
S. H. Nam ◽  
S. J. Choi ◽  
W. J. Seo ◽  
S. Hong ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Cox Regression ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Immunosuppressant Therapy ◽  
Muscle Enzymes ◽  
Cox Regression Analysis ◽  
Factors Associated ◽  
Early Use

Background:Several studies have been conducted on factors associated with mortality in idiopathic inflammatory myopathies (IIM), but few studies have assessed prognostic factors for steroid-free remission in IIM.Objectives:We investigated the various clinical factors, including body measurements, that affect IIM treatment outcomes.Methods:Patients who were newly diagnosed with IIM between 2000 and 2018 were included. Steroid-free remission was defined as at least three months of normalisation of muscle enzymes and no detectable clinical disease activity. The factors associated with steroid-free remission were evaluated by a Cox regression analysis.Results:Of the 106 IIM patients, 35 displayed steroid-free remission during follow-up periods. In the multivariable Cox regression analyses, immunosuppressants’ early use within one month after diagnosis [hazard ratio (HR) 6.21, 95% confidence interval (CI) 2.61–14.74, p < 0.001] and sex-specific height quartiles (second and third quartiles versus first quartile, HR 3.65, 95% CI 1.40–9.51, p = 0.008 and HR 2.88, 95% CI 1.13–7.32, p = 0.027, respectively) were positively associated with steroid-free remission. Polymyositis versus dermatomyositis (HR 0.21, 95% CI 0.09–0.53, p = 0.001), presence of dysphagia (HR 0.15, CI 0.05–0.50, p = 0.002) and highest versus lowest quartile of waist circumference (WC) (HR 0.24, 95% CI 0.07–0.85, p = 0.027) were negatively associated with steroid-free remission.Conclusion:The early initiation of immunosuppressant therapy, type of myositis and presence of dysphagia are strong predictors of steroid-free remission in IIM; moreover, height and WC measurements at baseline may provide additional important prognostic value.Disclosure of Interests:None declared

scholarly journals Prognostic factors for steroid-free remission in patients with idiopathic inflammatory myopathies: importance of anthropometric measurements

2020 ◽  
Vol 12 ◽  
pp. 1759720X2093682
Author(s):  
Jung Sun Lee ◽  
Jung Eun Lee ◽  
Seokchan Hong ◽  
Chang-Keun Lee ◽  
Bin Yoo ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Cox Regression ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Immunosuppressant Therapy ◽  
Muscle Enzymes ◽  
Cox Regression Analysis ◽  
Factors Associated ◽  
Early Use

Background: Several studies have been conducted on factors associated with mortality in idiopathic inflammatory myopathies (IIMs), but few studies have assessed prognostic factors for steroid-free remission in IIM. We investigated the various clinical factors, including body measurements, that affect IIM treatment outcomes. Methods: Patients who were newly diagnosed with IIM between 2000 and 2018 were included. Steroid-free remission was defined as at least 3 months of normalisation of muscle enzymes and no detectable clinical disease activity. The factors associated with steroid-free remission were evaluated by a Cox regression analysis. Results: Of the 106 IIM patients, 35 displayed steroid-free remission during follow-up periods. In the multivariable Cox regression analyses, immunosuppressants’ early use within 1 month after diagnosis [hazard ratio (HR) 6.21, 95% confidence interval (CI) 2.61–14.74, p < 0.001] and sex-specific height quartiles (second and third quartiles versus first quartile, HR 3.65, 95% CI 1.40–9.51, p = 0.008 and HR 2.88, 95% CI 1.13–7.32, p = 0.027, respectively) were positively associated with steroid-free remission. Polymyositis versus dermatomyositis (HR 0.21, 95% CI 0.09–0.53, p = 0.001), presence of dysphagia (HR 0.15, CI 0.05–0.50, p = 0.002) and highest versus lowest quartile of waist circumference (WC; HR 0.24, 95% CI 0.07–0.85, p = 0.027) were negatively associated with steroid-free remission. Conclusion: The early initiation of immunosuppressant therapy, type of myositis and presence of dysphagia are strong predictors of steroid-free remission in IIM; moreover, height and WC measurements at baseline may provide additional important prognostic value.

scholarly journals Factors associated with treatment response in patients with idiopathic inflammatory myopathies. A registry‐based study.

2020 ◽  
Author(s):  
Fabricio Espinosa‐Ortega ◽  
Marie Holmqvist ◽  
Maryam Dastmalchi ◽  
Ingrid E Lundberg ◽  
Helene Alexanderson
Keyword(s):  
Treatment Response ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Factors Associated

AB0936 Tuberculosis Infection in Mexican Patients with Idiopathic Inflammatory Myopathies: Report of three Cases and Review of the Literature

2015 ◽  
Vol 74 (Suppl 2) ◽  
pp. 1212.3-1212
Author(s):  
P.J. Pérez Cruz ◽  
E. Gόmez-Bañuelos ◽  
J.E. Aguilar-Arreola ◽  
A. Saldaña Millán ◽  
L. Andrade-Ortega ◽  
...  
Keyword(s):  
Tuberculosis Infection ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Review Of The Literature ◽  
Mexican Patients

scholarly journals Mortality and prognostic factors in idiopathic inflammatory myopathies

2020 ◽  
Vol 12 (3) ◽  
pp. 64-70
Author(s):  
Güllü Alakbarova ◽  
Döndü Üsküdar Cansu ◽  
Cengiz Korkmaz
Keyword(s):  
Prognostic Factors ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies

Extrapulmonary Tuberculosis Infection in Mexican Patients With Idiopathic Inflammatory Myopathies

2015 ◽  
Vol 21 (6) ◽  
pp. 331-332
Author(s):  
Mónica Vázquez- del Mercado ◽  
Eduardo Gomez-Bañuelos ◽  
Gabriel Medrano-Ramírez ◽  
Lilia Andrade-Ortega ◽  
Olga Vera-Lastra ◽  
...  
Keyword(s):  
Extrapulmonary Tuberculosis ◽  
Tuberculosis Infection ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Mexican Patients

scholarly journals Survival of Patients With Idiopathic Inflammatory Myopathies in Slovenia

2021 ◽  
Vol 8 ◽  
Author(s):  
Alojzija Hočevar ◽  
Andrej Viršček ◽  
Monika Krošel ◽  
Suzana Gradišnik ◽  
Žiga Rotar ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
General Population ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Standardized Mortality Ratio ◽  
First Year ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Mortality Ratio ◽  
Using Data

Background: Idiopathic inflammatory myopathies (IIMs) are rare systemic diseases associated with significant morbidity and mortality. The aim of our study was to estimate for the first time the survival of IIM patients in Slovenia.Methods: We included IIM patients diagnosed between January 2005 and December 2020 and followed at two secondary/tertiary rheumatology centers in the country. To study survival/mortality the censor date of April 14 2021 was set. Kaplan–Meier analysis and standardized mortality ratio (SMR) were plotted using data of age and sex matched Slovenian population as a reference. Cox proportional hazards regression analysis was used to study prognostic factors for IIM mortality.Results: During the 16-year observation period, we identified 217 new IIM patients. During follow up 65 (30.0%) patients died. In the first year following IIM diagnosis the SMR was nearly 7-fold higher compared to the matched general population [SMR 6.88 (95%CI 4.41–10.24)] and remained higher also during the following 4 years. However, when excluding IIM patients with cancer, the survival outcome was, except in the first year after IIM diagnosis [SMR 5.55 (95%CI 3.10–9.15)], comparable to matched general population. In addition to cancer [HR 3.71 (95% CI 2.18–6.04)], cardiac involvement [HR 2.18 (95% CI 1.07–4.45)], fever [HR 2.13 (95% CI 1.13–4.03)], and older age [HR 1.07 (95% CI 1.04–1.09)] were extracted as prognostic factors associated with death.Conclusion: The survival of patients with IIM patients was substantially worse compared to matched general population. Cancer was the leading cause of death in our cohort.

Sign in / Sign up

Export Citation Format

Share Document