What Is a Safe Distance for Preservation of the Inferior Alveolar Nerve in Lower Gingival Squamous Cell Carcinoma? A Radiographic and Histopathological Study

2019 ◽  
Vol 30 (4) ◽  
pp. e327-e330
Author(s):  
Reza Tabrizi ◽  
Zeinab Farahani ◽  
Mehrdad Dehghanpour Barouj ◽  
Mahtab Kheirkhahi ◽  
Mehrshad Jafari ◽  
...  

Background: The objective of surgical management of oral squamous cell carcinoma (OSCC) is adequate resection with a clear margin. However, there is still a debate as to the optimal length for a mandibular resected margin. Objective: To examine the length of peri-neural spreading in T4 mandibular invaded oral cavity squamous cell carcinoma. Materials and Methods: Twenty-eight T4 pathological OSCC specimens that involved mandible and serial slices were studied and the length of tumor spreading along the inferior alveolar nerve (IAN) was determined. Tumor characteristics, risk factors, and survival were analyzed. Results: The incidence of peri-neural invasion was 11.11%, and IAN invasion was found in 14.29% of the tumor-invaded mandibular marrow. The length of tumor spreading along IAN was 3 to 12 mm. Poor prognostic factors of T4 OSCC were it being located on the tongue (HR 14.16), was pathological N2-3 (HR 31.05), and had high-risk features such as peri-neural invasion, lymphovascular invasion, and extra-nodal extension. Conclusion: A mandibular resected margin of at least 18 mm is recommended as a clear surgical margin in cases of T4 mandibular invasion OSCC. Keywords: Oral cancer, Perineural invasion, Inferior alveolar nerve, Squamous cell carcinoma, Mandibulectomy


2007 ◽  
Vol 33 (2) ◽  
pp. 177-180 ◽  
Author(s):  
J LEE ◽  
S CHENG ◽  
S LIN ◽  
C CHIANG ◽  
C YU ◽  
...  

2003 ◽  
Vol 49 (3) ◽  
pp. 171-178
Author(s):  
Takahiko SHIBAHARA ◽  
Hiroyasu NOMA ◽  
Takeshi NOMURA ◽  
Ryo TAKAGI ◽  
Keiko YOKOO ◽  
...  

2021 ◽  
pp. 13-14
Author(s):  
Suraj Sinha ◽  
Suchitra Kumari ◽  
Rabindra Kumar Singh ◽  
Raj Kishor Kumar

Limb lesions of skin, soft tissue and bone are commonly encountered. They include a multitude of non neoplastic, benign and malignant diseases ranging from lipoma to brosarcoma and from epidermal cyst to squamous cell carcinoma. An insight of the pattern of various limb diseases in relation to site, age, and type of lesion assists in better comprehension of differential diagnosis for histopathologists. A retrospective study of histopathologically diagnosed cases of Material & Methods: 47 limb lesion patients from June 2020 to May 2021 was undertaken. A total 47 cases included 28 male and 19 female, Results: 55% of cases belong to age group 21 to 50 years. 13 (28%) cases were of upper extremity and 34 (72%) from lower extremity. 15 (34%) cases were non-neoplastic, 13 (28%) were benign lesion and rest 19 (38%) were malignant lesions. Lower limb lesions are more common than Conclusion: upper limb lesions. Squamous cell carcinoma is the most common malignant neoplasm and lipoma is the most common benign disease of extremity. Pyogenic granuloma and epidermal cyst were found to be the most common non-neoplastic extremity lesions. Fibrosarcoma was the most common type of sarcoma observed in 9% cases. Chronic osteomyelitis was the most common bony lesion.


2009 ◽  
Vol 124 (12) ◽  
pp. 2911-2916 ◽  
Author(s):  
Chizuru Hirano ◽  
Masaki Nagata ◽  
Arhab A. Noman ◽  
Nobutaka Kitamura ◽  
Makoto Ohnishi ◽  
...  

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