Individual Risk Factors and Complexity Associated with Congenital Heart Disease in a Pediatric Medicaid Cohort

Objective : This study was examined to identify the variables related to quality of life (QOL) in adolescents with congenital heart disease (CHD). Methods : The subjects were 266 adolescents with CHD under observation following cardiac surgery in three cardiac centers in Korea. The adolescents each completed twenty questionnaires. The exogenous variables in the model were individual risk factors, individual protective factors, family protective factors and social protective factors, while QOL and resilience were an endogenous variable. These six theoretical variables were assessed by 20 measurable variables (anxiety, depression, symptom distress, NYHA Functional class, oxygen saturation, number of operations, self-esteem, hope, attitude toward CHD, body image, academic achievement, family cohesion, family function, parental support, parental overprotection, socioeconomic status, friend support, teacher support, resilience and QOL) and 15 paths were established. Data were analysed using structural equation modelling. Results: The overall fit indices of the hypothetical model were χ2=26.63, GFI=.96, RMR=.02, NFI=.95, RFI=.85, IFI=.98 and PNFI=.87. All 15 paths in the hypothetical model were found to be significant(all, p<0.01). Higher resilience (t=11.93), family (t=7.88), individual (t=5.75), and social (t=4.14) protective factors were associated with increased QOL, as were lower individual risk factors (t=−5.30). Resilience had the greatest impact on QOL. Individual protective factors correlated positively with both family (t=8.88) and social (t=8.33) protective factors, while family factors correlated positively with social protective factors (t=9.31). Individual risk factors correlated negatively with family (t=−7.13), individual (t=−7.00) and social (t=−4.69) protective factors. Thus, the higher each of these protective factors was, the smaller the effect of individual risk factors. Conclusion: To increase the QOL of adolescents with CHD, it is important to develop a strategy to increase resilience. Furthermore, nursing interventions that will enhance individual, family, and social protective factors must be developed and implemented in order to reduce the negative effects of individual risk factors.

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Risk Factors for Gross Motor Dysfunction in Infants With Congenital Heart Disease

Infants & Young Children ◽

10.1097/iyc.0b013e3182176274 ◽

2011 ◽

Vol 24 (3) ◽

pp. 246-258 ◽

Cited By ~ 3

Author(s):

Suzanne H. Long ◽

Bev J. Eldridge ◽

Mary P. Galea ◽

Susan R. Harris

Keyword(s):

Risk Factors ◽

Congenital Heart Disease ◽

Heart Disease ◽

Congenital Heart ◽

Motor Dysfunction ◽

Gross Motor

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Nineteen Years of Adult Congenital Heart Surgery in a Single Center

World Journal for Pediatric and Congenital Heart Surgery ◽

10.1177/2150135116682454 ◽

2017 ◽

Vol 8 (2) ◽

pp. 182-188

Author(s):

Madurra Perinpanayagam ◽

Signe H. Larsen ◽

Kristian Emmertsen ◽

Marianne B. Møller ◽

Vibeke E. Hjortdal

Keyword(s):

Risk Factors ◽

Congenital Heart Disease ◽

Cardiac Surgery ◽

Heart Disease ◽

Postoperative Complications ◽

Adverse Events ◽

Congenital Heart ◽

Postoperative Bleeding ◽

Registration System ◽

Growing Population

Background: Adults with congenital heart disease are a growing population. We describe surgical interventions, short- and long-term mortality and morbidity, and risk factors for adverse events in a population-based cohort. Methods: Patients over or equal to 18 years with congenital heart disease who underwent cardiac surgery at Aarhus University Hospital, Denmark, from 1994 to 2012 were included in the study. Diagnoses, surgical procedures, postoperative complications, and survival were identified in hospital databases, medical records, and the Danish Civil Registration System. Results: Four hundred seventy-four surgeries were performed in 445 adults (50% men). The median age was 39 years (range 18-83). Thirty-nine percent had previous surgical or catheter-based interventions. Thirty-day and in-hospital mortality were 1.1%. Postoperative complications occurred in 50% of cases, most were minor such as temporary arrhythmias and pneumonia. Major complications included postoperative bleeding necessitating intervention (6%), stroke (2%), and acute temporary renal failure (1%). Multivariate analysis identified RACHS-1 categories over or equal to 3 compared to category 1 (odds ratio (OR) = 2.3; 95% confidence interval (CI): 1.5-3.7), New York Heart Association functional class III and IV compared to class I (OR = 2.2; 95% CI: 1.3-3.7) and age at surgery (OR = 1.03, 95% CI: 1.01-1.04), as risk factors for adverse events. Survival during a median follow-up of 7.8 years (range 0 days-21.4 years) was 85% (95% CI: 80%-89%). Conclusion: Adults with congenital heart disease constitute a growing population with the need for cardiac surgery. Postoperative complications are frequent but early and late mortality are low.

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Socio-hygienic and biomedical risk factors for congenital heart disease in children

Yakut Medical Journal ◽

10.25789/ymj.2018.62.37 ◽

2018 ◽

pp. 116-119

Author(s):

T.I. Nelunova ◽

T.E. Burtseva ◽

V.G. Chasnyk ◽

S.A. Evseeva

Keyword(s):

Risk Factors ◽

Congenital Heart Disease ◽

Heart Disease ◽

Congenital Heart

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Chylothorax after surgery on congenital heart disease in newborns and infants -risk factors and efficacy of MCT-diet

Journal of Cardiothoracic Surgery ◽

10.1186/1749-8090-5-127 ◽

2010 ◽

Vol 5 (1) ◽

Cited By ~ 43

Author(s):

Eva S Biewer ◽

Christoph Zürn ◽

Raoul Arnold ◽

Martin Glöckler ◽

Jürgen Schulte-Mönting ◽

...

Keyword(s):

Risk Factors ◽

Congenital Heart Disease ◽

Heart Disease ◽

Congenital Heart

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Risk factors for nosocomial infections after cardiac surgery in newborns with congenital heart disease

Pediatrics & Neonatology ◽

10.1016/j.pedneo.2018.07.009 ◽

2018 ◽

Vol 59 (4) ◽

pp. 327-328 ◽

Cited By ~ 1

Author(s):

Pei-Lan Shao

Keyword(s):

Risk Factors ◽

Congenital Heart Disease ◽

Cardiac Surgery ◽

Heart Disease ◽

Nosocomial Infections ◽

Congenital Heart

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Environmental Risk Factors and Congenital Heart Disease: An Umbrella Review of 165 Systematic Reviews and Meta-Analyses With More Than 120 Million Participants

Frontiers in Cardiovascular Medicine ◽

10.3389/fcvm.2021.640729 ◽

2021 ◽

Vol 8 ◽

Author(s):

Tie-Ning Zhang ◽

Qi-Jun Wu ◽

Ya-Shu Liu ◽

Jia-Le Lv ◽

Hui Sun ◽

...

Keyword(s):

Risk Factors ◽

Congenital Heart Disease ◽

Heart Disease ◽

Environmental Factors ◽

Congenital Heart ◽

Prediction Intervals ◽

Umbrella Review ◽

Wide Range ◽

Null Value ◽

Meta Analyses

Background: The etiology of congenital heart disease (CHD) has been extensively studied in the past decades. Therefore, it is critical to clarify clear hierarchies of evidence between types of environmental factors and CHD.Methods: Electronic searches in PubMed, Embase, Web of Science, Cochrane database were conducted from inception to April 20, 2020 for meta-analyses investigating the aforementioned topic.Results: Overall, 41 studies including a total of 165 meta-analyses of different environmental factors and CHD were examined, covering a wide range of risk factors. The summary random effects estimates were significant at P < 0.05 in 63 meta-analyses (38%), and 15 associations (9%) were significant at P < 10−6. Of these meta-analyses, eventually one risk factor (severe obesity; relative risk: 1.38, 95% confidence interval: 1.30–1.47) had significant summary associations at P < 10−6, included more than 1,000 cases, had 95% prediction intervals excluding the null value, and were not suggestive of large heterogeneity (I2 < 50%), small-study effects (P-value for Egger's test > 0.10), or excess significance (P > 0.10). Eight associations (5%) (including maternal lithium exposure, maternal obesity, maternal alcohol consumption, and maternal fever) had results that were significant at P < 10−6, included more than 1,000 cases, and had 95% prediction intervals excluding the null value (highly suggestive).Conclusion: This umbrella review shows that many environmental factors have substantial evidence in relation to the risk of developing CHD. More and better-designed studies are needed to establish robust evidence between environmental factors and CHD.Systematic Review Registration: [PROSPERO], identifier [CRD42020193381].

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Risk Factors Associated with Congenital Heart Disease in Patients Presenting to Aljalila Cardiology Clinic between January 2020- May 2020: A Case Control Study

Journal of Cardiology Research Review & Reports ◽

10.47363/jcrrr/2021(3)143 ◽

2021 ◽

pp. 1-6

Author(s):

Samah Alasrawi ◽

◽

Hessa Almansoori ◽

Keyword(s):

Risk Factors ◽

Congenital Heart Disease ◽

Heart Disease ◽

Maternal Smoking ◽

Congenital Heart ◽

Case Control Study ◽

Maternal Diabetes ◽

Case Control ◽

Cardiology Clinic ◽

Control Study

Objective: To investigate the association of maternal diabetes, maternal smoking and syndromes with congenital heart disease (CHD) in patients attending Aljalila cardiology clinic between January 2020 and May of 2020. Methods: A case control study to assess the association of maternal diabetes, maternal smoking and syndromes with CHD. All patients that presented to the clinic between January 2020 and May of 2020 were included. An interviewer administered questionnaire was used to record the presence of maternal diabetes, maternal smoking, and the type of syndrome and type of CHD. Patients with CHD were included in the case group and patients who did not have CHD were in the control group. Age, gender, and nationality were also collected from the hospital records. Fisher exact test and logistic regression was used to analyze the results. Results: A total of 177 cases and 211 controls were recruited. All the risk factors increase the risk of CHD, with maternal diabetes (OR 6.3, 95% CI 2.7-14.6) having the strongest association, then syndromes (OR 5.1, 95% CI 2.3-11.3) and lastly maternal smoking (OR 4.0, 95% CI 1.0-16.3). The most common type of CHD is ventricular septal defect. Conclusion: Maternal diabetes, maternal smoking and syndromes are significant risk factors of CHD in children visiting Aljalila cardiology clinic. Action needs to be taken in order to decrease these risk factors and so, decrease the incidence of CHD in the future. Clearly, more research is needed in order to identify other risk factors for patients in the United Arab Emirates (UAE)

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