Minocycline Promotes Long-Term Survival of Neuronal Transplant in the Brain by Inhibiting Late Microglial Activation and T-Cell Recruitment

2010 ◽  
Vol 89 (7) ◽  
pp. 816-823 ◽  
Author(s):  
Delphine Michel-Monigadon ◽  
Véronique Nerrière-Daguin ◽  
Xavier Lévèque ◽  
Martine Plat ◽  
Eric Venturi ◽  
...  
Keyword(s):  
T Cell ◽  
Microglial Activation ◽  
Term Survival ◽  
Long Term Survival ◽  
Cell Recruitment ◽  
The Brain

EXTH-13. LOCAL DELIVERY OF AN IL-15 SUPERAGONIST USING A REPLICATING RETROVIRUS SIGNIFICANTLY IMPROVES SURVIVAL AND LYMPHOCYTE INFILTRATION IN POORLY IMMUNOGENIC MURINE GLIOBLASTOMA MODELS

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi166-vi166
Author(s):  
Alexander Haddad ◽  
Jordan Spatz ◽  
Megan Montoya ◽  
Sara Collins ◽  
Sabraj Gill ◽  
...  
Keyword(s):  
T Cell ◽  
Median Survival ◽  
T Cell Activation ◽  
Term Survival ◽  
Long Term Survival ◽  
Immunosuppressive Cell ◽  
Imaging Results ◽  
Local Immunosuppression ◽  
Inflammatory Changes

Abstract Glioblastoma (GBM) leads to severe systemic and local immunosuppression, and immunotherapies have had limited clinical success. Here, we evaluated the treatment efficacy of RLI, a superagonist of T-cell activator IL-15, delivered to tumor cells using a tumor-selective retroviral replicating vector (RRV) in the syngeneic murine SB28 and Tu2449 GBM models, which are both engineered to be poorly immunogenic with low-mutational burden and known resistance to immunotherapy, and hence more accurate biomimetic models of human GBM. RRV-RLI replicated and spread effectively in cultured murine GBM cells with robust production of functional RLI (165.4 ± 5.3 ng/mL). Stereotactic injection of RRV-RLI into pre-established intracerebral SB28 tumors significantly reduced tumor growth on bioluminescent imaging, and increased median survival compared to control mice (55 vs. 19 days, p=0.002), leading to long-term survival in 12% of treated mice. In the Tu2449 model, imaging results showed complete eradication of intracerebral tumors after RRV-RLI treatment, with long-term survival (median not reached) in > 85% of treated mice, compared to a median survival of 12.5 days in control mice (p=0.001). RRV-RLI treated tumors showed significantly increased CD8 T-cell infiltration, without altering immunosuppressive cell populations. Similarly, broad anti-tumor inflammatory changes, including increased expression of genes involved in T-cell activation and killing, were observed in the NanoString nCounter platform using a 770-gene panel representing various immune cell types. Notably, RLI was not detected in the blood of treated mice, and tumor-localized RRV-RLI gene delivery showed no adverse systemic immune effects in either model. In summary, RRV-mediated RLI immunotherapy results in immunostimulatory and pro-inflammatory changes to the tumor microenvironment and achieves a significant survival benefit in two poorly immunogenic syngeneic murine models of GBM. This tumor-localized immunomodulatory gene therapy has the potential to safely reverse the T-cell depleted immunophenotype of GBM.

Primary alveolar rhabdomyosarcoma of the brain with long-term survival

2013 ◽  
Vol 115 (1) ◽  
pp. 131-133 ◽  
Author(s):  
Mahmoud Reza Khalatbari ◽  
Mehrdokht Hamidi ◽  
Yashar Moharamzad
Keyword(s):  
Alveolar Rhabdomyosarcoma ◽  
Term Survival ◽  
Long Term Survival ◽  
The Brain

scholarly journals Autologous cancer cell vaccination, adoptive T ‐cell transfer, and interleukin‐2 administration results in long‐term survival for companion dogs with osteosarcoma

2020 ◽  
Vol 34 (5) ◽  
pp. 2056-2067
Author(s):  
Brian K. Flesner ◽  
Gary W. Wood ◽  
Pamela Gayheart‐Walsten ◽  
F. Lynn Sonderegger ◽  
Carolyn J. Henry ◽  
...  
Keyword(s):  
T Cell ◽  
Cancer Cell ◽  
Interleukin 2 ◽  
Cell Transfer ◽  
Term Survival ◽  
Adoptive T Cell Transfer ◽  
Long Term Survival ◽  
Companion Dogs ◽  
T Cell Transfer

scholarly journals ACTR-18. MOLECULAR GENETIC, HOST-DERIVED AND CLINICAL DETERMINANTS OF LONG-TERM SURVIVAL IN GLIOBLASTOMA: AN UPDATE FROM THE BRAIN TUMOR FUNDERS’ COLLABORATIVE CONSORTIUM

2016 ◽  
Vol 18 (suppl_6) ◽  
pp. vi5-vi5
Author(s):  
Caroline Happold ◽  
Riccardo Soffietti ◽  
Christine Marosi ◽  
Jaap Reijneveld ◽  
Gabriele Schackert ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Molecular Genetic ◽  
Term Survival ◽  
Long Term Survival ◽  
The Brain

scholarly journals Long‐term survival of pig‐to‐rhesus macaque renal xenografts is dependent on CD4 T cell depletion

2019 ◽  
Vol 19 (8) ◽  
pp. 2174-2185 ◽  
Author(s):  
Steven C. Kim ◽  
David V. Mathews ◽  
Cynthia P. Breeden ◽  
Laura B. Higginbotham ◽  
Joseph Ladowski ◽  
...  
Keyword(s):  
T Cell ◽  
Rhesus Macaque ◽  
Cd4 T Cell ◽  
Cell Depletion ◽  
Term Survival ◽  
T Cell Depletion ◽  
Long Term Survival

Long-term survival of pig proislet xenografts in CD4+ T cell-depleted mice

1990 ◽  
Vol 3 (1) ◽  
pp. 95
Author(s):  
Charmaine J. Simeonovic ◽  
Rhodri Ceredig ◽  
J.Dennis Wilson
Keyword(s):  
T Cell ◽  
Cd4 T Cell ◽  
Term Survival ◽  
Long Term Survival

scholarly journals Long term survival after treatment of disseminated T cell lymphoma presenting with tracheal obstruction in a patient with coeliac disease.

Thorax ◽  
1989 ◽  
Vol 44 (6) ◽  
pp. 519-520 ◽  
Author(s):  
D J Seddon ◽  
K F Chung ◽  
F J Paradinas ◽  
E S Newlands ◽  
P D Snashall
Keyword(s):  
T Cell ◽  
Coeliac Disease ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Term Survival ◽  
Long Term Survival ◽  
Tracheal Obstruction

T Cell Infiltrate Predicts Long-Term Survival Following Resection of Colorectal Cancer Liver Metastases

2009 ◽  
Vol 16 (9) ◽  
pp. 2524-2530 ◽  
Author(s):  
Steven C. Katz ◽  
Venu Pillarisetty ◽  
Zubin M. Bamboat ◽  
Jinru Shia ◽  
Cyrus Hedvat ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
T Cell ◽  
Liver Metastases ◽  
Cell Infiltrate ◽  
Colorectal Cancer Liver Metastases ◽  
Term Survival ◽  
Long Term Survival
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