Genetic Polymorphisms of the Transcription Factor NFATc4 and Development of New-Onset Diabetes After Transplantation in Hispanic Kidney Transplant Recipients

2012 ◽  
Vol 93 (3) ◽  
pp. 325-330 ◽  
Author(s):  
Yan Chen ◽  
Marcelo S. Sampaio ◽  
Jae Wook Yang ◽  
David Min ◽  
Ian V. Hutchinson
Keyword(s):  
Transcription Factor ◽  
Kidney Transplant ◽  
Genetic Polymorphisms ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Onset Diabetes ◽  
New Onset

Clinical Variables and Outcomes of Kidney Transplant Recipients with Type 2 Diabetes and New-Onset Diabetes after Transplantation in a Predominantly Minority Urban Population

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 541-P
Author(s):  
SANDRA ALEKSIC ◽  
SARA ZAHEDPOUR ANARAKI ◽  
EFFIE TSOMOS ◽  
LAXMI UPADHYAY ◽  
EMILY JAPP ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Kidney Transplant ◽  
Urban Population ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Clinical Variables ◽  
Onset Diabetes ◽  
Predominantly Minority ◽  
New Onset

Single-centre study of 628 adult, primary kidney transplant recipients showing no unfavourable effect of new-onset diabetes after transplant

Diabetologia ◽  
2014 ◽  
Vol 58 (2) ◽  
pp. 334-345 ◽  
Author(s):  
Jeffrey J. Gaynor ◽  
Gaetano Ciancio ◽  
Giselle Guerra ◽  
Junichiro Sageshima ◽  
Lois Hanson ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Single Centre ◽  
Centre Study ◽  
Onset Diabetes ◽  
Unfavourable Effect ◽  
Single Centre Study ◽  
New Onset

Comparison of New Onset Diabetes according to the Time of Onset in Kidney Transplant Recipients

2009 ◽  
Vol 23 (2) ◽  
pp. 149
Author(s):  
Kyu Jong Yoon ◽  
Jun Ho Park ◽  
Doo Jin Kim ◽  
Sung Gil Park ◽  
Jeong Hoon Lee ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Onset Diabetes ◽  
New Onset

Multivariable risk of developing new onset diabetes after transplant-results from a single-center study of 481 adult, primary kidney transplant recipients

2015 ◽  
Vol 29 (4) ◽  
pp. 301-310 ◽  
Author(s):  
Jeffrey J. Gaynor ◽  
Gaetano Ciancio ◽  
Giselle Guerra ◽  
Junichiro Sageshima ◽  
Lois Hanson ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Transplant Recipients ◽  
Single Center ◽  
Kidney Transplant Recipients ◽  
Onset Diabetes ◽  
Single Center Study ◽  
Center Study ◽  
New Onset

scholarly journals Analysis of the frequency of single nucleotide polymorphisms in cytokine genes in patients with New Onset Diabetes After Transplant

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mohamed Jahromi ◽  
Torki Al-Otaibi ◽  
Osama Ashry Gheith ◽  
Nashwa Farouk Othman ◽  
Tarek Mahmoud ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Transforming Growth Factor ◽  
Interferon Γ ◽  
Cytokine Profile ◽  
Control Group ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Onset Diabetes ◽  
Metabolic Complication ◽  
New Onset

AbstractNew Onset Diabetes After Transplantation (NODAT) is a serious metabolic complication. While β-cell dysfunction is considered the main contributing factor in the development of NODAT, the precise pathogenesis is not well understood. Cytokines are thought to be involved in the inflammation of islet β-cells in diabetes; however, few studies have investigated this hypothesis in NODAT. A total of 309 kidney transplant recipients (KTRs) were included in this study. An association between kidney transplants, and the development of diabetes after transplant (NODAT) was investigated. Comparison was made between KTRs who develop diabetes (NODAT cases) or did not develop diabetes (control), using key cytokines, IL-6 G (− 174)C, macrophage mediator; IL-4 C (− 490)T, T helper (Th)-2 cytokine profile initiator; Th-1 cytokine profile initiator interferon-γ T (+ 874) A gene and TGF β1 C (+ 869) T gene polymorphisms were investigated. The genes were amplified using well-established polymerase chain reaction (PCR) techniques in our laboratory. Compared to the AA and AT genotypes of interferon gamma (IFNG), there was a strong association between the TT genotype of IFNG and NODAT kidney transplant recipients (KTRs) versus non-NODAT KTRs (p = 0.005). The AA genotype of IFNG was found to be predominant in the control group (p = 0.004). Also, significant variations of IL6 G (− 174) C, IL-4 C (− 590) T, interferon-γ T (+ 874) A gene and transforming growth factor β1 C (+ 869) T may contribute to NODAT. Our data is consistent with theTh-1/T-reg pathway of immunity. Further larger pan Arab studies are required to confirm our findings.

scholarly journals Risk Factors for New-Onset Diabetes After Transpant in Kidney Transplant Recipients

2019 ◽  
Vol 2 (1) ◽  
pp. 29-32
Author(s):  
Dana Pramudya ◽  
Aditiawardana Aditiawardana ◽  
Artaria Tjempakasari ◽  
Chandra Irwanadi ◽  
Nunuk Mardiana ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Onset Diabetes ◽  
New Onset
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