Role of central arginine vasopressin receptors in the analgesic effect of CDP-choline on acute and neuropathic pain

Studies conducted in recent years have helped define the role of antidepressant drugs in the management of cancer pain. The anti-nociceptive action of these agents seems to be independent of beneficial effect on depression or mood. Among antidepressant drugs, those of the tricyclic class are preferred when an analgesic effect is sought. Their primary application is for pain due to nerve injury, so-called “neuropathic pain”. Although the co-administration of tricyclic antidepressants may increase plasma morphine concentrations, any potentiation of morphine analgesia is thought not to be due to an increased bioavailability of the opiate, but to an intrinsic analgesic effect of antidepressants. On this basis, the use of antidepressants in combination with opioids for the treatment of cancer pain is suitable when a component of deafferentation is present or when there is concomitant depressive illness.

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Glucose-induced downregulation of angiotensin II and arginine vasopressin receptors in cultured rat aortic vascular smooth muscle cells. Role of protein kinase C.

Journal of Clinical Investigation ◽

10.1172/jci116079 ◽

1992 ◽

Vol 90 (5) ◽

pp. 1992-1999 ◽

Cited By ~ 51

Author(s):

B Williams ◽

P Tsai ◽

R W Schrier

Keyword(s):

Smooth Muscle ◽

Protein Kinase C ◽

Angiotensin Ii ◽

Protein Kinase ◽

Smooth Muscle Cells ◽

Vascular Smooth Muscle Cells ◽

Arginine Vasopressin ◽

Kinase C ◽

Vasopressin Receptors

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Role of spinal adenosine A1 receptors in the analgesic effect of electroacupuncture in a rat model of neuropathic pain

Journal of International Medical Research ◽

10.1177/0300060519883748 ◽

2019 ◽

Vol 48 (4) ◽

pp. 030006051988374 ◽

Cited By ~ 1

Author(s):

Qin-xue Dai ◽

Lu-ping Huang ◽

Yun-chang Mo ◽

Li-na Yu ◽

Wen-wen Du ◽

...

Keyword(s):

Spinal Cord ◽

Neuropathic Pain ◽

Analgesic Effect ◽

High Performance ◽

Pain Thresholds ◽

Adenosine A1 Receptors ◽

Thermal Pain ◽

Adenosine A1 ◽

Zusanli Acupoint

Objective The aim of this study was to determine the role of spinal adenosine A1 receptors (A1Rs) in the analgesic effects of electroacupuncture (EA) for neuropathic pain. Methods We performed EA for 30 minutes at the zusanli acupoint in the legs of rats with previously induced chronic constriction injuries and observed the mechanical and thermal pain thresholds 1 hour later. We also examined adenosine levels by high-performance liquid chromatography and A1R expression in the L4–6 spinal cord by western blot analysis. We then injected A1R short interfering RNA (AV-shA1RNA) into the L4–6 spinal cord to downregulate A1R expression and re-examined the mechanical and thermal pain thresholds. Results Adenosine levels and A1R expression in the L4–6 spinal cord were increased at 1 hour after EA. In addition, EA exhibited an analgesic effect that was reversed by AV-shA1RNA. Conclusions Our results suggest that EA at the zusanli acupoint elicits an analgesic effect against neuropathic pain, mediated by A1Rs in the spinal cord.

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Spinal Nitric Oxide Contributes to the Analgesic Effect of Intrathecal [D-Pen2,D-Pen5]-Enkephalin in Normal and Diabetic Rats

Anesthesiology ◽

10.1097/00000542-200301000-00033 ◽

2003 ◽

Vol 98 (1) ◽

pp. 217-222 ◽

Cited By ~ 17

Author(s):

Shao-Rui Chen ◽

Hui-Lin Pan

Keyword(s):

Nitric Oxide ◽

Neuropathic Pain ◽

Opioid Receptor ◽

Rat Model ◽

Analgesic Effect ◽

Antinociceptive Effect ◽

Diabetic Rats ◽

Delta Opioid Receptor ◽

Diabetic Neuropathic Pain

Background Spinal nitric oxide (NO) is important for the analgesic actions of morphine and cholinergic agents. Its role in the analgesic effect of delta-opioid receptor agonists is not known. In the present study, the authors determined the role of spinal endogenous NO in the antinociceptive effect of intrathecal [D-Pen2, D-Pen5 ]-enkephalin (DPDPE), a delta-opioid receptor agonist, in normal rats and a rat model of diabetic neuropathic pain. Methods Rats were rendered diabetic with streptozotocin (50 mg/kg, intraperitoneal). Intrathecal catheters were implanted in age-matched normal and diabetic rats. Nociceptive thresholds were determined by application of a noxious pressure stimulus to the hind paw. The dose-dependent effect of intrathecal DPDPE was first determined. The role of spinal NO in the analgesic effect of intrathecal DPDPE was then examined through intrathecal treatments with NO synthase inhibitors (NMMA and TRIM) and a specific NO scavenger (carboxy-PTIO). Results The diabetic rats developed a sustained mechanical hyperalgesia within 3 weeks after streptozotocin injection. Intrathecal DPDPE, 2-20 micro g, dose-dependently increased the withdrawal threshold in response to the noxious pressure in normal and diabetic rats. However, the ED(50) of DPDPE in diabetic rats was about twofold higher than that in normal rats. Intrathecal pretreatment with NMMA, TRIM, or carboxy-PTIO diminished the analgesic effect of DPDPE in both normal and diabetic rats. Furthermore, the inhibitory effect of NMMA on the action of intrathecal DPDPE was reversed by intrathecal l-arginine but not d-arginine. Conclusions Intrathecal DPDPE produces an antinociceptive effect in normal rats and a rat model of diabetic neuropathic pain. Spinal endogenous NO contributes importantly to the analgesic action of intrathecal DPDPE in both normal and diabetic neuropathic pain conditions.

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Faculty Opinions recommendation of How central is central poststroke pain? The role of afferent input in poststroke neuropathic pain: a prospective, open-label pilot study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732892352.793551838 ◽

2018 ◽

Author(s):

Marshall Devor

Keyword(s):

Neuropathic Pain ◽

Pilot Study ◽

Afferent Input ◽

Open Label

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Analgesic Effect of Ketoprofen Is Mainly Associated to its R-Enantiomer: Role of Cytokine Modulation

Analgesia ◽

10.3727/107156999819565829 ◽

1999 ◽

Vol 4 (2) ◽

pp. 181-186 ◽

Cited By ~ 1

Author(s):

Riccardo Bertini ◽

Gianfranco Caselli

Keyword(s):

Analgesic Effect ◽

Cytokine Modulation

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Emerging Role of microRNA in Neuropathic Pain

Current Drug Metabolism ◽

10.2174/1389200216666151015113400 ◽

2016 ◽

Vol 17 (4) ◽

pp. 336-344 ◽

Cited By ~ 31

Author(s):

Pu Jiangpan ◽

Meng Qingsheng ◽

Yang Zhiwen ◽

Zhu Tao

Keyword(s):

Neuropathic Pain

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Pre-motor versus motor cerebral cortex neuromodulation for chronic neuropathic pain

Scientific Reports ◽

10.1038/s41598-021-91872-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Igor Lavrov ◽

Timur Latypov ◽

Elvira Mukhametova ◽

Brian Lundstrom ◽

Paola Sandroni ◽

...

Keyword(s):

Neuropathic Pain ◽

Cerebral Cortex ◽

Motor Cortex ◽

Initial Assessment ◽

Motor Cortex Stimulation ◽

Chronic Neuropathic Pain ◽

Long Term Effect ◽

Stimulation Of

AbstractElectrical stimulation of the cerebral cortex (ESCC) has been used to treat intractable neuropathic pain for nearly two decades, however, no standardized approach for this technique has been developed. In order to optimize targeting and validate the effect of ESCC before placing the permanent grid, we introduced initial assessment with trial stimulation, using a temporary grid of subdural electrodes. In this retrospective study we evaluate the role of electrode location on cerebral cortex in control of neuropathic pain and the role of trial stimulation in target-optimization for ESCC. Location of the temporary grid electrodes and location of permanent electrodes were evaluated in correlation with the long-term efficacy of ESCC. The results of this study demonstrate that the long-term effect of subdural pre-motor cortex stimulation is at least the same or higher compare to effect of subdural motor or combined pre-motor and motor cortex stimulation. These results also demonstrate that the initial trial stimulation helps to optimize permanent electrode positions in relation to the optimal functional target that is critical in cases when brain shift is expected. Proposed methodology and novel results open a new direction for development of neuromodulation techniques to control chronic neuropathic pain.

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