scholarly journals Daily torpor is associated with telomere length change over winter in Djungarian hamsters

2011 ◽  
Vol 8 (2) ◽  
pp. 304-307 ◽  
Author(s):  
Christopher Turbill ◽  
Steve Smith ◽  
Caroline Deimel ◽  
Thomas Ruf
Keyword(s):  
Telomere Length ◽  
Energy Savings ◽  
Physiological State ◽  
Length Change ◽  
Phodopus Sungorus ◽  
Physiological Changes ◽  
Daily Torpor ◽  
Positive Effects ◽  
Relative Telomere Length ◽  
Air Temperatures

Ageing can progress at different rates according to an individual's physiological state. Natural hypothermia, including torpor and hibernation, is a common adaptation of small mammals to survive intermittent or seasonal declines in environmental conditions. In addition to allowing energy savings, hypothermia and torpor have been associated with retarded ageing and increased longevity. We tested the hypothesis that torpor use slows ageing by measuring changes in the relative telomere length (RTL) of Djungarian hamsters, Phodopus sungorus , a highly seasonal rodent using spontaneous daily torpor, over 180 days of exposure to a short-day photoperiod and warm (approx. 20°C) or cold (approx. 9°C) air temperatures. Multi-model inference showed that change in RTL within individuals was best explained by positive effects of frequency of torpor use, particularly at low body temperatures, as well as the change in body mass and initial RTL. Telomere dynamics have been linked to future survival and proposed as an index of rates of biological ageing. Our results therefore support the hypothesis that daily torpor is associated with physiological changes that increase somatic maintenance and slow the processes of ageing.

scholarly journals Seasonal variation in telomere length of a hibernating rodent

2013 ◽  
Vol 9 (2) ◽  
pp. 20121095 ◽  
Author(s):  
Christopher Turbill ◽  
Thomas Ruf ◽  
Steve Smith ◽  
Claudia Bieber
Keyword(s):  
Telomere Length ◽  
Seasonal Changes ◽  
Life History Traits ◽  
Physiological State ◽  
Telomere Shortening ◽  
Active Season ◽  
Somatic Maintenance ◽  
Relative Telomere Length ◽  
Length Increase ◽  
Negative Effect

Small hibernating rodents have greater maximum lifespans and hence appear to age more slowly than similar-sized non-hibernators. We tested for a direct effect of hibernation on somatic maintenance and ageing by measuring seasonal changes in relative telomere length (RTL) in the edible dormouse Glis glis . Average RTL in our population did not change significantly over the hibernation season, and a regression model explaining individual variation in post-hibernation RTL suggested a significant negative effect of the reduction in body mass over the inactive hibernation period (an index of time spent euthermic), supporting the idea that torpor slows ageing. Over the active season, RTL on average decreased in sub-adults but increased in adults, supporting previous findings of greater telomere shortening at younger ages. Telomere length increase might also have been associated with reproduction, which occurred only in adults. Our study reveals how seasonal changes in physiological state influence the progress of life-history traits, such as somatic maintenance and ageing, in a small hibernating rodent.

scholarly journals Glucocorticoids, state-dependent reproductive investment and success in the face of danger in a long-lived bird

2020 ◽  
Author(s):  
Kristina Noreikienė ◽  
Kim Jaatinen ◽  
Benjamin B. Steele ◽  
Markus Öst
Keyword(s):  
Predation Risk ◽  
Telomere Length ◽  
Clutch Size ◽  
Body Condition ◽  
Nest Predation ◽  
Hatching Success ◽  
Reproductive Investment ◽  
Trade Off ◽  
Relative Telomere Length ◽  
Future Reproduction

AbstractGlucocorticoid hormones may mediate trade-offs between current and future reproduction. However, understanding their role is complicated by predation risk, which simultaneously affects the value of the current reproductive investment and elevates glucocorticoid levels. Here, we shed light on these issues in long-lived female Eiders (Somateria mollissima) by investigating how current reproductive investment (clutch size) and hatching success relate to faecal glucocorticoid metabolite [fGCM] level and residual reproductive value (minimum years of breeding experience, body condition, relative telomere length) under spatially variable predation risk. Our results showed a positive relationship between colony-specific predation risk and mean colony-specific fGCM levels. Clutch size and female fGCM were negatively correlated only under high nest predation and in females in good body condition, previously shown to have a longer life expectancy. We also found that younger females with longer telomeres had smaller clutches. The drop in hatching success with increasing fGCM levels was least pronounced under high nest predation risk, suggesting that elevated fGCM levels may allow females to ensure some reproductive success under such conditions. Hatching success was positively associated with female body condition, with relative telomere length, particularly in younger females, and with female minimum age, particularly under low predation risk, showing the utility of these metrics as indicators of individual quality. In line with a trade-off between current and future reproduction, our results show that high potential for future breeding prospects and increased predation risk shift the balance toward investment in future reproduction, with glucocorticoids playing a role in the resolution of this trade-off.

Efficacy of prayer in inducing immediate physiological changes: a systematic analysis of objective experiments

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Felix Chin ◽  
Ryan Chou ◽  
Muhammad Waqas ◽  
Kunal Vakharia ◽  
Hamid Rai ◽  
...  
Keyword(s):  
Physiological State ◽  
Experimental Studies ◽  
Peripheral Resistance ◽  
Pain Tolerance ◽  
Physiological Status ◽  
Physiological Changes ◽  
Mental Functioning ◽  
Baroreceptor Sensitivity ◽  
Systematic Analysis ◽  
Blood Marker

Abstract Objectives To assess the immediate impact of prayer on physiological state by systematically reviewing objective, controlled experimental studies in the literature. Content Experimental studies measuring objective physiological changes induced by prayer. Studies containing the keyword, “Prayer” anywhere in the title or abstract were curated from the following databases: Public/Publisher Medline (PubMed), Excerpta Medica Database (EMBASE) and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) in May 2019. Titles and abstracts were screened with the remaining 30 articles analyzed for inclusion. Only experimental studies were included. Summary Eight experimental studies were identified of which five investigated neurocognitive changes and three investigated systemic physiological changes during prayer. The five studies focusing on neuroactivity used functional MRI (fMRI), electroencephalography or SPECT imaging to obtain measurements. The remaining three studies analyzed an array of systemic physiological metrics, including blood pressure, heart rate, respiratory rate, peripheral resistance, baroreceptor sensitivity and/or cardiovascular rhythm variability during prayer. All studies aside from one saw objective changes during prayer. Neurocognitive changes were mainly associated with improved mental functioning, control and pain tolerance. Prayer was found to slow down physiological functions in two of the three vital-based studies, with the third reporting no change in physiological status. None of the studies measured blood marker changes. Outlook Experimental studies show prayer to induce healthy neurocognitive and physiological changes. Additional studies exploring objective measures from prayer are encouraged to provide practitioners with a more nuanced, scientific perspective when it comes to prescribing prayer as a complementary and alternative medicine (CAM) therapy.

Correlation between metabolic syndrome and relative telomere length shortening in HIV/AIDS patients on combined antiretroviral therapy

2021 ◽  
Vol 147 ◽  
pp. 111269
Author(s):  
Gordana Dragović ◽  
Mladen Andjić ◽  
Boško Toljić ◽  
Djordje Jevtović ◽  
Relja Lukić ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Antiretroviral Therapy ◽  
Telomere Length ◽  
Aids Patients ◽  
Relative Telomere Length ◽  
Combined Antiretroviral Therapy ◽  
Hiv Aids

scholarly journals Urinary arsenic and relative telomere length in 5–7 year old children in Bangladesh

2021 ◽  
Vol 156 ◽  
pp. 106765
Author(s):  
Shohreh F. Farzan ◽  
Mohammad Shahriar ◽  
Muhammad G. Kibriya ◽  
Farzana Jasmine ◽  
Golam Sarwar ◽  
...  
Keyword(s):  
Telomere Length ◽  
Urinary Arsenic ◽  
Relative Telomere Length

scholarly journals The Chemistry of Cold: Mechanisms of Torpor Regulation in the Siberian Hamster

Physiology ◽  
2016 ◽  
Vol 31 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Ceyda Cubuk ◽  
Jonathan H. H. Bank ◽  
Annika Herwig
Keyword(s):  
Physiological State ◽  
Daily Torpor ◽  
Brain Areas ◽  
Siberian Hamster ◽  
Siberian Hamsters ◽  
Save Energy

Siberian hamsters use spontaneous daily torpor, a state of hypometabolism and hypothermia, to save energy during winter. Multiple neuroendocrine signals set the scene for spontaneous torpor to occur, and several brain areas have been identified as potential sites for torpor regulation. Here, we summarize the known mechanisms of a fascinating physiological state in the Siberian hamster.

MULTIDOMAIN LIFESTYLE INTERVENTION, TELOMERE LENGTH CHANGE AND COGNITION: THE FINGER TRIAL

2017 ◽  
Vol 13 (7) ◽  
pp. P927
Author(s):  
Shireen Sindi ◽  
Ingemar Kåreholt ◽  
Tiia Ngandu ◽  
Iiris Hovatta ◽  
Dharma Singh Khalsa ◽  
...  
Keyword(s):  
Telomere Length ◽  
Lifestyle Intervention ◽  
Length Change

scholarly journals Review of existing energy management standards and possibilities for its introduction in Serbia

2010 ◽  
Vol 14 (3) ◽  
pp. 613-623 ◽  
Author(s):  
Dubravka Jelic ◽  
Dusan Gordic ◽  
Milun Babic ◽  
Davor Koncalovic ◽  
Vanja Sustersic
Keyword(s):  
Best Practices ◽  
Energy Management ◽  
Energy Efficient ◽  
Management Practices ◽  
Energy Savings ◽  
Management Strategies ◽  
Current Status ◽  
Positive Effects ◽  
Management Standards ◽  
Current State

Until recent times, energy management practices primarily consisted in replacing inefficient equipment and then using any number of methods to estimate obtained savings. Experience shows that positive effects of energy efficient improvements were decreased over time. There have been significant efforts over the last decade to define appropriate standards and best practices and implement the consistent energy management system to increase and maintain the energy savings. The knowledge gained from thousands of energy efficient projects is driving a transition from traditional tactical practice (one-time "build and forget" projects) to energy management strategies proposed and endorsed by a number of international organizations. The current status of internationally developed energy management standards, including an analysis of their shared features and differences is presented in this paper. The purpose of the analysis is to describe the current state of ?best practices? for this emerging area of energy efficiency policymaking in order to study the possibility of implementation of energy management standards in Serbia and to estimate the effects and the potential for energy saving that would be made by its implementation.

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