MULTIDOMAIN LIFESTYLE INTERVENTION, TELOMERE LENGTH CHANGE AND COGNITION: THE FINGER TRIAL

2017 ◽  
Vol 13 (7) ◽  
pp. P927
Author(s):  
Shireen Sindi ◽  
Ingemar Kåreholt ◽  
Tiia Ngandu ◽  
Iiris Hovatta ◽  
Dharma Singh Khalsa ◽  
...  
Keyword(s):  
Telomere Length ◽  
Lifestyle Intervention ◽  
Length Change

scholarly journals Telomere length change in a multidomain lifestyle intervention to prevent cognitive decline: a randomized clinical trial

2020 ◽  
Author(s):  
Shireen Sindi ◽  
Alina Solomon ◽  
Ingemar Kåreholt ◽  
Iiris Hovatta ◽  
Riitta Antikainen ◽  
...  
Keyword(s):  
At Risk ◽  
Telomere Length ◽  
Lifestyle Intervention ◽  
Healthy Lifestyle ◽  
Length Change ◽  
Cognitive Change ◽  
Cognitive Intervention ◽  
Lifestyle Changes ◽  
Control Group ◽  
Long Term Memory

Abstract Background Shorter leukocyte telomere length (LTL) is associated with aging and dementia. Impact of lifestyle changes on LTL, and relation to cognition and genetic susceptibility for dementia has not been investigated in randomised controlled trials (RCT). Methods Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a 2-year RCT enrolling 1260 participants at-risk for dementia from the general population, aged 60-77 years, randomly assigned (1:1) to multidomain lifestyle intervention or control group. Primary outcome was cognitive change (Neuropsychological Test Battery NTB z-score). Relative LTL was measured using quantitative real-time polymerase chain reaction. Trial registration: NCT01041989. Results This exploratory LTL sub-study included 756 participants (377 intervention, 379 control) with baseline and 24-month LTL measurements. Mean annual LTL change (SD) was -0.016 (0.19) in intervention, and -0.023 (0.17) in control group. Between-group difference was non-significant (unstandardised β-coefficient 0.007, 95%CI -0.015-0.030). Interaction analyses indicated better LTL maintenance among APOEε4 carriers vs non-carriers: 0.054 (95%CI 0.007-0.102); younger vs older participants: -0.005 (95%CI -0.010 ‒ -0.001); and those with more vs less healthy lifestyle changes: 0.047 (95%CI 0.005-0.089). Cognitive intervention benefits were more pronounced among participants with better LTL maintenance for executive functioning (0.227, 95%CI 0.057–0.396) and long-term memory (0.257, 95%CI 0.024 – 0.489), with a similar trend for NTB total score (0.127, 95%CI -0.011–0.264). Conclusion This is the first large RCT showing that a multidomain lifestyle intervention facilitated LTL maintenance among sub-groups of elderly at-risk for dementia, including APOEε4 carriers. LTL maintenance was associated with more pronounced cognitive intervention benefits.

scholarly journals A Comprehensive, Multidisciplinary, Personalized, Lifestyle Intervention Program is Associated with Increased Leukocyte Telomere Length in Children and Adolescents with Overweight and Obesity

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2682
Author(s):  
George Paltoglou ◽  
Christina Raftopoulou ◽  
Nicolas C. Nicolaides ◽  
Sofia M. Genitsaridi ◽  
Sofia I. Karampatsou ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Telomere Length ◽  
Lifestyle Intervention ◽  
Intervention Program ◽  
Overweight And Obesity ◽  
Initial Assessment ◽  
Biological Aging ◽  
Childhood And Adolescence ◽  
Lifestyle Interventions ◽  
Lifestyle Intervention Program

Leucocyte telomere length (LTL) is a robust marker of biological aging and is associated with obesity and cardiometabolic risk factors in childhood and adolescence. We investigated the effect of a structured, comprehensive, multidisciplinary, personalized, lifestyle intervention program of healthy diet and physical exercise on LTL in 508 children and adolescents (239 males, 269 females; 282 prepubertal, 226 pubertal), aged 10.14 ± 0.13 years. Participants were classified as obese (n = 267, 52.6%), overweight (n = 174, 34.2%), or of normal BMI (n = 67, 13.2%) according to the International Obesity Task Force (IOTF) cutoff points and were studied prospectively for one year. We demonstrated that LTL increased significantly after 1 year of the lifestyle interventions, irrespective of gender, pubertal status, or body mass index (BMI). Waist circumference was the best negative predictor of LTL at initial assessment. The implementation of the lifestyle interventions also resulted in a significant improvement in clinical (BMI, BMI z-score and waist to height ratio) and body composition indices of obesity, inflammatory markers, hepatic enzymes, glycated hemoglobin (HbA1C), quantitative insulin sensitivity check index (QUICKI), and lipid profile in all participants. These findings indicate that the increased LTL may be associated with a more favorable metabolic profile and decreased morbidity later in life.

scholarly journals Daily torpor is associated with telomere length change over winter in Djungarian hamsters

2011 ◽  
Vol 8 (2) ◽  
pp. 304-307 ◽  
Author(s):  
Christopher Turbill ◽  
Steve Smith ◽  
Caroline Deimel ◽  
Thomas Ruf
Keyword(s):  
Telomere Length ◽  
Energy Savings ◽  
Physiological State ◽  
Length Change ◽  
Phodopus Sungorus ◽  
Physiological Changes ◽  
Daily Torpor ◽  
Positive Effects ◽  
Relative Telomere Length ◽  
Air Temperatures

Ageing can progress at different rates according to an individual's physiological state. Natural hypothermia, including torpor and hibernation, is a common adaptation of small mammals to survive intermittent or seasonal declines in environmental conditions. In addition to allowing energy savings, hypothermia and torpor have been associated with retarded ageing and increased longevity. We tested the hypothesis that torpor use slows ageing by measuring changes in the relative telomere length (RTL) of Djungarian hamsters, Phodopus sungorus , a highly seasonal rodent using spontaneous daily torpor, over 180 days of exposure to a short-day photoperiod and warm (approx. 20°C) or cold (approx. 9°C) air temperatures. Multi-model inference showed that change in RTL within individuals was best explained by positive effects of frequency of torpor use, particularly at low body temperatures, as well as the change in body mass and initial RTL. Telomere dynamics have been linked to future survival and proposed as an index of rates of biological ageing. Our results therefore support the hypothesis that daily torpor is associated with physiological changes that increase somatic maintenance and slow the processes of ageing.

Telomere length change in European sea bass (Dicentrarchus labrax)

2008 ◽  
Vol 56 (3) ◽  
pp. 207 ◽  
Author(s):  
T. Horn ◽  
N. J. Gemmell ◽  
B. C. Robertson ◽  
C. R. Bridges
Keyword(s):  
Telomere Length ◽  
Repetitive Sequences ◽  
Dicentrarchus Labrax ◽  
Sea Bass ◽  
Length Change ◽  
European Sea Bass ◽  
Intraspecies Variation ◽  
Individual Fitness ◽  
Response To Stress ◽  
Made In

Telomeres, the repetitive sequences found at the end of chromosomes, are observed to shorten with age in birds and mammals, but to date no investigation on changes of telomere length has been made in long-lived marine fish during ageing. We have measured the telomere length of European sea bass (Dicentrarchus labrax) ranging in age from 12 to 94 months. No overall decrease of telomere length could be detected, but a broad range of intraspecies variation was observed. Telomere length change does not appear to be useful for estimating age in this species, but may prove a useful tool for examining individual fitness and response to stress.

Associations of telomere length with two dietary quality indices after a lifestyle intervention in children with abdominal obesity: a randomized controlled trial

2020 ◽  
Vol 15 (11) ◽  
Author(s):  
Ana Ojeda‐Rodríguez ◽  
Lydia Morell‐Azanza ◽  
Guillermo Zalba ◽  
Itziar Zazpe ◽  
Maria Cristina Azcona‐Sanjulian ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Telomere Length ◽  
Lifestyle Intervention ◽  
Abdominal Obesity ◽  
Controlled Trial ◽  
Dietary Quality ◽  
Quality Indices ◽  
Randomized Controlled

scholarly journals Telomere length shortening in hospitalized preterm infants: A pilot study

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0243468
Author(s):  
Mandy Brown Belfort ◽  
Farah Qureshi ◽  
Jonathan Litt ◽  
Michelle Bosquet Enlow ◽  
Immaculata De Vivo ◽  
...  
Keyword(s):  
Telomere Length ◽  
Preterm Infants ◽  
Health Risks ◽  
Gestational Age ◽  
Neonatal Intensive Care ◽  
Length Change ◽  
Dried Blood Spots ◽  
Leukocyte Telomere Length ◽  
Real Time Quantitative Pcr ◽  
Gestational Age At Birth

Leukocyte telomere length is a biomarker of aging-related health risks. Hospitalized preterm infants frequently experience elevated oxidative stress and inflammation, both of which contribute to telomere shortening. Our aim was to examine changes in telomere length during neonatal intensive care unit (NICU) hospitalization in a cohort of preterm infants <32 weeks’ gestation. We conducted a longitudinal study of 10 infants (mean gestational age 27 weeks, range 23.5 to 29, at birth). We isolated DNA from dried blood spots and used Real Time Quantitative PCR to measure relative leukocyte telomere length in triplicate at three time points for each participant. From birth to discharge, infants experienced an average decline in relative telomere length of 0.021 units per week (95% CI -0.040, -0.0020; p = 0.03), after adjustment for gestational age at birth. Our results suggest a measurable decline in telomere length during NICU hospitalization. We speculate that telomere length change may convey information about NICU exposures that carry short- and long-term health risks.

scholarly journals Telomere length change plateaus at 4 years of age in Latino children: associations with baseline length and maternal change

2016 ◽  
Vol 291 (3) ◽  
pp. 1379-1389 ◽  
Author(s):  
Janet M. Wojcicki ◽  
Stephen Shiboski ◽  
Melvin B. Heyman ◽  
Deena Elwan ◽  
Jue Lin ◽  
...  
Keyword(s):  
Telomere Length ◽  
Length Change ◽  
Baseline Length ◽  
Latino Children

Association between favourable changes in objectively measured physical activity and telomere length after a lifestyle intervention in pediatric patients with abdominal obesity.

2020 ◽  
Author(s):  
Ana Ojeda-Rodríguez ◽  
Lydia Morell-Azanza ◽  
Nerea Martín-Calvo ◽  
Guillermo Zalba ◽  
María Chueca ◽  
...  
Keyword(s):  
Physical Activity ◽  
Telomere Length ◽  
Lifestyle Intervention ◽  
Abdominal Obesity ◽  
Usual Care Group ◽  
Pediatric Patients ◽  
Intervention Group ◽  
Care Group ◽  
Intensive Phase

The purpose of this study was to assess the effect of physical activity (PA) changes, measured by accelerometry, on telomere length (TL) in pediatric patients with abdominal obesity after a lifestyle intervention. 121 children with abdominal obesity (7-16 years old) were randomized to the intervention (moderately hypocaloric Mediterranean Diet) or usual care group (standard pediatrics recommendations) for 22 months (a 2-month intensive phase and a subsequent 20-month follow-up). Both groups were encouraged to accumulate extra 200 min/week of PA. TL was measured by MMqPCR. Data were analyzed in 102 subjects after 2-month and 64 subjects at the first 10 months of follow-up. Light PA level decreased in both groups after 12-month of intervention. At month 2, moderate-to-vigorous PA (MVPA) incremented in the intervention group (+5.4 min/day, p=0.035) and so did sedentary time in the usual care group (+49.7 min/day, p=0.010). TL changes were positively associated (p<0.050) with metabolic equivalents (METs), MVPA level and number of steps; and inversely associated with sedentary and light PA levels in the intervention group after the intensive phase. In conclusion, favourable changes in PA levels in the intensive phase of a lifestyle intervention could contribute to TL maintenance in pediatric population with abdominal obesity. Novelty: • Changes in physical activity levels had a direct effect on telomere length, a biomarker of cellular aging and oxidative stress. • PA advice based on The American College of Sports Medicine included in this intervention is easy to implement in primary care.

Associations of telomere length with anthropometric and glucose changes after a lifestyle intervention in abdominal obese children

2020 ◽  
Vol 30 (4) ◽  
pp. 694-700 ◽  
Author(s):  
Lydia Morell-Azanza ◽  
Ana Ojeda-Rodríguez ◽  
Ma Cristina Azcona-SanJulián ◽  
Guillermo Zalba ◽  
Amelia Marti
Keyword(s):  
Telomere Length ◽  
Lifestyle Intervention ◽  
Obese Children

scholarly journals Telomere Length and the Transition to Family Caregiving in the REGARDS Study

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 818-819
Author(s):  
William Haley ◽  
Nicole Armstrong ◽  
Ryan Irvin ◽  
Marcela Blinka ◽  
Rasika Mathias ◽  
...  
Keyword(s):  
Socioeconomic Factors ◽  
Telomere Length ◽  
Racial Differences ◽  
Well Being ◽  
Length Change ◽  
Single Copy ◽  
Adverse Outcomes ◽  
Telomere Attrition ◽  
Age Related ◽  
Regards Study

Abstract An increase in life expectancy and an aging population has resulted in increased risks and prevalence of age-related diseases. Previous studies have shown that factors, such as chronic stress, are associated with shorter telomere length. When telomeres become critically short, cells enter a state of senescence, which is a hallmark of aging. Several prior studies examining the relationship between caregiving and telomere length have reported mixed results. The present study utilized data from the Caregiving Transitions Study, an ancillary study to the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. The difference in telomere length across an average ~8.6 years was compared between 235 incident caregivers and 229 controls. Telomere length was determined using the qPCR telomere-to-single copy gene (IFNB1) ratio (T/S) for each participant at both baseline and follow-up timepoints. Regression models controlling for age, sex, race, and baseline telomere length examined the association between caregiving status (exposure) and the telomere length change (□T/S). Sensitivity models adjusted for potential lifestyle and socioeconomic factors, including income, education, BMI, cigarette smoking, and alcohol use. We did not observe a significant association between □T/S and caregiving (beta=0.041, p=0.615). Adding lifestyle and socioeconomic factors did not change the null relationship (beta=0.062, p=0.455). In conclusion, this study provides evidence against an association between caregiving and the change in telomere length. Ultimately, more research to address the complex relationship between caregiving and telomere attrition is needed in order to prevent or reduce adverse outcomes and improve the well-being of caregivers and care recipients.

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